Potential Health Risks of Chloroacetanilide Herbicides: An In Silico Analysis

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dc.contributor.authorBerber, Ahmet Ali
dc.contributor.authorDemir, Şefika Nur
dc.contributor.authorKenanoğlu, Nihan Akıncı
dc.date.accessioned2025-01-27T19:20:26Z
dc.date.available2025-01-27T19:20:26Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe extensive use of herbicidal products in agriculture and forestry has raised concerns over potential adverse effects on human health and the environment. Chloroacetanilide herbicides are a group of synthetic chemicals used to control weeds in agriculture and forestry. However, so[me of their members have been characterized as possible carcinogens. The genotoxicity and carcinogenicity of two chloroacetanilide herbicides, delachlor and xylachlor, are discussed. This article proposes to use tools to predict their potential toxicities based on their chemical structure. Four software tools, Vega Hub, Toxtree, Lazar, and TEST, are used to predict the potential genotoxic and carcinogenic effects of the herbicides. Vega Hub uses QSAR models, Toxtree uses a decision tree approach, Lazar uses data mining algorithms, and TEST uses QSAR methods to estimate toxicity. The canonical Simplified Molecular Input Line Entry Specification (SMILES) systems of delachlor and xylachlor are entered into each software tool to create a prediction. The study found that delachlor and xylachlor is a class 3 highly toxic compounds with potential mutagenic and carcinogenic effects based on Toxtree and Vega Hub. Meanwhile, Lazar and TEST predicted that delachlor and xylachlor are unlikely to be mutagenic. This study to determine the toxicity of the herbicides delachlor and xylachlor has shown that the possible effects of these herbicides on health and the environment need to be further investigated. The results provide valuable insights into chloroacetanilide herbicide toxicity and help develop safer, more environmentally friendly alternatives.
dc.identifier.doi10.16984/saufenbilder.1281720
dc.identifier.endpage871
dc.identifier.issn1301-4048
dc.identifier.issn2147-835X
dc.identifier.issue4
dc.identifier.startpage865
dc.identifier.trdizinid1194036
dc.identifier.urihttps://doi.org/10.16984/saufenbilder.1281720
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1194036
dc.identifier.urihttps://hdl.handle.net/20.500.12428/14868
dc.identifier.volume27
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofSakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectBiyoloji
dc.subjectKimya
dc.subjectUygulamalı
dc.subjectÇevre Bilimleri
dc.subjectToksikoloji
dc.subjectFarmakoloji ve Eczacılık
dc.titlePotential Health Risks of Chloroacetanilide Herbicides: An In Silico Analysis
dc.typeArticle

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