Synthesis and characterization of 2-aminoethylphosphonic acid-functionalized graphene quantum dots: biological activity, antioxidant activity and cell viability

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dc.contributor.authorYapar, Gonul
dc.contributor.authorSenel, Behiye
dc.contributor.authorDemir, Neslihan
dc.contributor.authorYıldız, Mustafa
dc.date.accessioned2025-01-27T20:26:51Z
dc.date.available2025-01-27T20:26:51Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractA facile, environmentally friendly one-step reaction for the preparation of luminescent N-doped graphene quantum dots (GQDs) involving a hydrothermal reaction between citric acid and 2-aminoethylphosphonic acid has been designed. Graphene quantum dots have been characterized by UV-visible absorption, FTIR spectroscopy, transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX) and dynamic light scattering (DLS) techniques. Furthermore, the biological activity of the GQDs has been studied. UV-visible spectroscopy studies of the interactions between the GQDs and calf thymus DNA (CT-DNA) showed that the compound interacts with CT-DNA via intercalative binding. DNA cleavage study showed that the GQDs cleaved DNA oxidatively. In addition, antioxidant activity of N-doped GQDs was measured using the DPPH method. As the concentration of the compound increased, the antioxidant activity also has increased. According to cell viability analyses results, the N-doped GQDs showed cell viability (70%) when the concentration reaches 228 mu g/mL for A549, 200 mu g/mL for MDA-MB-231 and 140 mu g/mL for NIH-3T3 cell lines with 24 h incubation.
dc.identifier.endpage323
dc.identifier.issn0376-4710
dc.identifier.issn0975-0975
dc.identifier.issue3
dc.identifier.startpage317
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22458
dc.identifier.volume59
dc.identifier.wosWOS:000525084900002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherNatl Inst Science Communication-Niscair
dc.relation.ispartofIndian Journal of Chemistry Section A-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectN-doped graphene quantum dots
dc.subjectBiological activity
dc.subjectAntioxidant activity
dc.subjectMTT
dc.subjectCell viability
dc.titleSynthesis and characterization of 2-aminoethylphosphonic acid-functionalized graphene quantum dots: biological activity, antioxidant activity and cell viability
dc.typeArticle

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