Preparation of collagen based composite materials with synthetic polymers for potential wound dressing applications

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dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorBütün, Sultan
dc.contributor.authorAlpaslan, Duygu
dc.contributor.authorBitlisli, B. Oral
dc.date.accessioned2025-01-27T19:57:45Z
dc.date.available2025-01-27T19:57:45Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCollagen is very important part of the fibrous proteins in the living organism. Animal tissues, especially tendons main structure contain collagen. In this investigation, natural collagen (coll) modified with different synthetic monomers such as 2-hydroxy ethylmethacrylate (HEMA) and acrylamide (AAm) was prepared as p(Coll-co-HEMA) and p(Coll-co-AAm) composites to enhance collagen natural characteristics. Biocompatibility of the prepared interpenetrating polymeric network (IPN) was tested with MTT Assay and found biocompatible. Model drugs, such as Trimetoprim (TMP) and Naproxene (NP) were used as antibacterial active agents for release studies from the synthesized composite hydrogel-collagen IPN matrices. The drug-loaded IPN films release studies were carried out in bio-mimetic media. It was found that collagen-synthetic polymer matrices can be readily prepared and used for drug delivery system in the release of active agents, providing great potential in wound dressing applications.
dc.identifier.endpage69
dc.identifier.issn1303-5002
dc.identifier.issn2687-475X
dc.identifier.issue1
dc.identifier.startpage63
dc.identifier.trdizinid489013
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/489013
dc.identifier.urihttps://hdl.handle.net/20.500.12428/19716
dc.identifier.volume42
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofHacettepe Journal of Biology and Chemistry
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectBiyoloji
dc.subjectMühendislik
dc.subjectBiyotıp
dc.subjectDermatoloji
dc.subjectHücre ve Doku Mühendisliği
dc.subjectSağlık Bilimleri ve Hizmetleri
dc.subjectMalzeme Bilimleri
dc.subjectBiyomalzemeler
dc.titlePreparation of collagen based composite materials with synthetic polymers for potential wound dressing applications
dc.typeArticle

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