Effect of Coenzyme Q10 on Acute Pulmonary Damage Following the Experimental Thoracic Trauma

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dc.authoridKoyuncu, Murat/0000-0001-7446-1641
dc.contributor.authorKoyuncu, Murat
dc.contributor.authorAvsarogullari, Omer Levent
dc.contributor.authorDuman, Ali
dc.contributor.authorDeniz, Kemal
dc.contributor.authorSaraymen, Recep
dc.contributor.authorOzkan, Seda
dc.contributor.authorDurukan, Polat
dc.date.accessioned2025-01-27T21:21:13Z
dc.date.available2025-01-27T21:21:13Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: Pulmonary contusion negatively affects prognosis in the case of damages following a trauma. Objective of this experimental study performed in Turkey was to evaluate effects of coenzyme Q10 on primary and secondary damages of pulmonary contusion following experimental thoracic blunt trauma using biochemical and histopathological parameters. Material and Method: A total of 56 Wistar Albino female rats with a mean weight of 205 45 g were included in this study. Rats were randomly divided into seven groups with each group having eight rats. A trauma device which consisted of a fixed platform, and an aluminium tube was prepared. Rats were administered 2.45 J of chest impact energy in order to generate pulmonary contusion. Control and Study groups were named according to the sacrificed time. No process (trauma and/or medication) was performed in the sham group, while only trauma was induced in the controls. On the other hand, after induced trauma. intraperitoneal Q10 (0.-24.-48. hours) was administered to study group. Rats were sacrificed at the end of the after trauma 24, 48 and 72 hours. and their blood and lung tissue samples were analyzed. Results: No significant difference was found between sham and Study-72 groups in terms of high-sensitivity C-reactive protein. On the histopathological examination, no significant difference was found between study and control groups. While no significant difference was found between the sham and study groups, significant difference was observed between sham and control groups. Discussion: Coenzyme Q10, an antioxidant agent, can be used as an antioxidant agent in order to reduce the secondary damage in blunt thoracic trauma.
dc.identifier.doi10.4328/JCAM.3718
dc.identifier.endpage816
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.startpage811
dc.identifier.urihttps://doi.org/10.4328/JCAM.3718
dc.identifier.urihttps://hdl.handle.net/20.500.12428/28840
dc.identifier.volume6
dc.identifier.wosWOS:000215600200020
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherDerman Medical Publ
dc.relation.ispartofJournal of Clinical and Analytical Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectThoracic Injuries
dc.subjectCoenzyme Q10
dc.subjectAnimal Experimentation
dc.titleEffect of Coenzyme Q10 on Acute Pulmonary Damage Following the Experimental Thoracic Trauma
dc.typeArticle

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