Nanogel synthesis by irradiation of aqueous polymer solutions

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dc.authorscopusid6602001525en_US
dc.authorwosidKVP-4764-2024en_US
dc.contributor.authorSütekin, S. Duygu
dc.contributor.authorGüven, Olgun
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-02-07T06:03:08Z
dc.date.available2025-02-07T06:03:08Z
dc.date.issued2021en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümüen_US
dc.description.abstractNanogels/microgels are intramolecularly crosslinked particles with submicron diameters that can swell in a suitable solvent due to their three-dimensional network structure. Nanogels provide beneficial features such as flexibility, biocompatibility, high stability and swelling, fixed shape, large surface/volume ratio, fast stimuli-responsive behavior, etc. Therefore, there is growing interest to further elaborate nanogel formulations in preclinical applications as therapeutics, diagnostics, or nanosensors. However, conventional nanogel synthesis methods may end up with nanogels containing toxic residuals, e.g., initiator, crosslinking agent, and fragments which possess a major disadvantage in biomedical applications requiring tedious purification steps. This chapter reviews the synthesis of nanogels by irradiation of dilute aqueous polymer solutions to induce intramolecular crosslinking by gamma rays or accelerated electrons. This simple, ecofriendly, and cost-effective manufacturing method eliminates the purification step and provides the possibility to produce clean nanogels with desired sizes at room temperature. In the formation of nanogels, the degree of crosslinking can be controlled by polymer solution properties as well as operational parameters such as dose rate of radiation source and total absorbed dose. The method can be applied to many water-soluble polymers, copolymers, or interpolymer complexes for the development of nanogels with desired sizes and properties.en_US
dc.identifier.citationSütekin, S. D., Güven, O., & Şahiner, N. (2021). Nanogel synthesis by irradiation of aqueous polymer solutions. In J. K. Patel & Y. V. Pathak (Eds.), Emerging Technologies for Nanoparticle Manufacturing (pp. 167–202). https://doi.org/10.1007/978-3-030-50703-9_8en_US
dc.identifier.doi10.1007/978-3-030-50703-9_8en_US
dc.identifier.endpage202en_US
dc.identifier.isbn9783030507039
dc.identifier.isbn9783030507022
dc.identifier.scopus2-s2.0-85114054438en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage167en_US
dc.identifier.urihttps://doi.org/10.1007/978-3-030-50703-9_8
dc.identifier.urihttps://hdl.handle.net/20.500.12428/29569
dc.indekslendigikaynakScopus
dc.institutionauthorŞahiner, Nurettin
dc.institutionauthorid0000-0003-0120-530X
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.ispartofEmerging Technologies for Nanoparticle Manufacturingen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrosslinkingen_US
dc.subjectE-beamen_US
dc.subjectGammaen_US
dc.subjectIonizing radiationen_US
dc.subjectNanogelsen_US
dc.titleNanogel synthesis by irradiation of aqueous polymer solutionsen_US
dc.typebookParten_US

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