The microbiome in infant gut health and development

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dc.authoridDuman, Hatice / 0000-0002-4526-6609
dc.authoridKarav, Sercan / 0000-0003-4056-1673
dc.contributor.authorAlipour, Zahra
dc.contributor.authorDuman, Hatice
dc.contributor.authorLee, Joseph
dc.contributor.authorKarav, Sercan
dc.contributor.authorFrese, Steven
dc.date.accessioned2025-01-27T18:53:22Z
dc.date.available2025-01-27T18:53:22Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis review investigates the gut microbiome’s impact on the immune system’s development early in life. Various factors influence the gut microbiome, including maternal factors, feeding method, gestation age, and environmental factors such as antibiotic exposure. A dysfunctional gut microbiome is characterized by a higher abundance of Proteobacteria and a lower abundance of bifidobacteria, associated with a higher incidence of inflammation followed by elevated levels of inflammatory cytokines. The presence of some beneficial microbes, such as Bifidobacterium longum subs. infantis, in particular, which is highly adapted to the infant’s gut environment, and human milk oligosaccharides, has shown promising advantages to infants’ health. Reduced inflammatory markers, enhanced immune system development, and possibly a lowered chance of developing an autoimmune disease are the beneficial effects of early colonization with Bifidobacterium infantis. Modern lifestyles have potentially reduced the prevalence of bifidobacteria, particularly B. infantis, in infants’ guts, associated with an increased risk of developing life-threatening complications such as asthma, allergies, and autoimmune disease. Changes in modern lifestyle factors, such as childbirth and feeding practices, gestational age, and antibiotic use, have reduced the prevalence of B. infantis in young children. Reintroducing B. infantis to breast-fed infants is possible, however. Providing B. infantis during breastfeeding reduced inflammatory markers and mortality among preterm infants.
dc.identifier.doi10.1016/B978-0-443-18979-1.00003-4
dc.identifier.endpage49
dc.identifier.isbn978-044318979-1
dc.identifier.isbn978-044318980-7
dc.identifier.scopus2-s2.0-85213189104
dc.identifier.scopusqualityN/A
dc.identifier.startpage29
dc.identifier.urihttps://doi.org/10.1016/B978-0-443-18979-1.00003-4
dc.identifier.urihttps://hdl.handle.net/20.500.12428/12692
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofNutrition in the Control of Inflammation: Emerging Roles for the Microbiome and Epigenome
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subjecteffect of health on development
dc.subjectGut physiology
dc.subjectimmune response
dc.subjectinfant
dc.subjectmicrobiology
dc.subjectmicrobiome
dc.titleThe microbiome in infant gut health and development
dc.typeBook Chapter

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