Hepatoprotective and nephroprotective effects of Trigonella foenum-graecum L. (Fenugreek) seed extract against sodium nitrite toxicity in rats

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dc.authoridAdali, Yasemen/0000-0002-8004-7364
dc.contributor.authorAtila Uslu, Gozde
dc.contributor.authorUslu, Hamit
dc.contributor.authorAdali, Yasemen
dc.date.accessioned2025-01-27T20:49:43Z
dc.date.available2025-01-27T20:49:43Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Feeding habits and environmental factors may rival genetic susceptibility as etiological factors related to various cancers. Humans are continuously exposed to many synthetic food additives, one of which is sodium nitrite (NaNO2). There is a direct correlation between increases in consumption of nitrite-treated products and incidence of tissue damage, hepatotoxicity, nephrotoxicity and some types of cancer. The objective of this study was to investigate the protective effects of Trigonella foenurn-graecum (TFG) on NaNO2-induced hepatotoxicity and nephrotoxicity. Methods: Forty rats were randomly assigned (10 per group) to control (physiological saline solution), TFG (150 mg/kg/day), NaNO2 (80 mg/kg/day), and NaNO2+TFG (80 mg/kg/day + 150 mg/kg/day) groups. This group was offered TFG seed extract two hours before NaNO2. At the end of three months, the rats were decapitated, and blood, kidney and liver tissues were removed. Results: Three months of oral administration of NaNO2 increased serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, and pro-inflammatory cytokine levels in the liver and kidney tissues [except for liver Interleukin 1 alpha (IL-1 alpha)] of rats. Serum AST, ALT, urea, creatinine, liver IL-6, and kidney tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-1 alpha levels significantly decreased in the NaNO2 +TFG group compared to the NaNO2 group. Pathological examinations, it was determined show that exogenously administered TFG could alleviate the effects of NaNO2 hepatotoxicity and nephrotoxicity. Conclusions: Our results suggest that exogenous TFG mitigates NaNO2-administration induced hepatotoxicity and nephrotoxicity. TFG extract exerted antioxidative and anti-inflammatory effects, and played a significant role in preventing hepatic and renal damage induced by chronic NaNO2 administration.
dc.identifier.doi10.15419/bmrat.v6i5.540
dc.identifier.endpage3150
dc.identifier.issn2198-4093
dc.identifier.issue5
dc.identifier.startpage3142
dc.identifier.urihttps://doi.org/10.15419/bmrat.v6i5.540
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25287
dc.identifier.volume6
dc.identifier.wosWOS:000470736300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherBiomedpress
dc.relation.ispartofBiomedical Research and Therapy
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectHepatotoxicity
dc.subjectNephrotoxicity
dc.subjectPro-inflammatory cytokine
dc.subjectSodium nitrite
dc.subjectTrigonella foenum-graecum
dc.titleHepatoprotective and nephroprotective effects of Trigonella foenum-graecum L. (Fenugreek) seed extract against sodium nitrite toxicity in rats
dc.typeArticle

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