Genetic polymorphism of BMP-6 gene (rs267196 and rs267192) in patients with ankylosing spondylitis

Objective: Bone morphogenetic proteins (BMPs) have been documented to be associated with ankylosing spondylitis (AS) in several populations. The goal of the present study was to determine the association of the (BMP-6) gene polymorphism (rs267192 and rs267196) with AS and to evaluate the relationships between them based on clinical and laboratory data. Methods: This study was conducted during August and November 2013 at the physical therapy and rehabilitation outpatient clinics of çanakkale Onsekiz Mart University Research and Practice Hospital. 42 AS patients and 58 healthy controls were checked with reverse transcription-polymerase chain reaction (RT-PCR) analysis for BMP-6 (rs267192 and rs267196) polymorphism. Clinical data as age, gender, body mass index, C-reactive protein (CRP), erythrocyte sedimentation rate, bath ankylosing spondylitis disease activity index (BASDAI), and HLA-27 positivity were assessed. It was evaluated the relationship between the BMP-6 polymorphism and laboratory findings. Results: The frequencies of AA, AT, and TT genotypes for BMP-6 rs267196 were 9.5% (n=4), 38.1% (n=16), and 52.4% (n=22) in AS patients, and 15.5% (n=9), 44.8% (n=26), and 39.7% (n=23) in controls respectively. BMP-6 rs267196 A allele carriers (versus T ancient allele) had 1.4-fold higher risk and rs267192 T allele carriers (versus C ancient allele) had 1.08-fold higher risk for AS. There was no significant difference between AS and control groups in terms of age, gender and BMI. The CRP and sedimentation levels of the AS group were significantly higher than the control group (p < 0.001). Conclusion: Although some studies have suggested BMP-6 polymorphisms as a possible risk factor for AS, BMP-6, rs267196 and rs267192 alleles were not associated with the disease risk in this study groups. © 2019, Refik Saydam National Public Health Agency (RSNPHA).