Prophylactic feeding with immune-enhanced diet ameliorates chemoradiation-induced gastrointestinal injury in rats

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dc.authoridAbacioglu, Ufuk/0000-0002-3950-8616
dc.authoridAral, Cenk/0000-0002-6044-1372
dc.authoridYegen, Berrak/0000-0003-0791-0165
dc.contributor.authorAtasoy, Beste M.
dc.contributor.authorDeniz, Mustafa
dc.contributor.authorDane, Faysal
dc.contributor.authorOzen, Zeynep
dc.contributor.authorTuran, Pinar
dc.contributor.authorErcan, Feriha
dc.contributor.authorCerikcioglu, Nilguen
dc.date.accessioned2025-01-27T20:20:14Z
dc.date.available2025-01-27T20:20:14Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractMaterials and methods: Forty-eight Sprague-Dawley rats were divided into control (C, n = 6), irradiation (IR, n = 14), fluoropyrimidine (5-FU, n = 14)-treated, IR + 5-FU (n = 14)-treated groups. Half of each irradiated and/or 5-FU-treated groups were previously fed with IED containing arginine, omega-3-fatty acids and RNA fragments, while the other half were fed a standard rat diet (SD) for eight days before the induction of IR or injection of 5-FU. In IR groups, whole abdominal irradiation (11 Gy) was performed with 6 MV photons. In the 5-FU groups, fluoropyrimidine (100 mg/kg) was administered intraperitoneally 30 min prior to irradiation. All animals were sacrificed on the 4th day of IR or 5-FU injection. Results: Bacterial colony counts in the ceca and mesenteric lymph nodes of IED-fed rats, which have received either 5-FU and/or irradiation were significantly lower than the corresponding SD-fed groups. Morphometric results revealed that gastric, ileal and colonic injuries were less in IED-treated IR or IR + 5-FU + IED groups, as compared to SD-fed groups. However, IED did not alter DNA fragmentation ratios. Conclusion: Prophylactic feeding of IED has a protective effect on chemoradiation-induced gastrointestinal injury, which appears to involve the eradication of bacterial overgrowth.
dc.identifier.doi10.3109/09553002.2010.487026
dc.identifier.endpage879
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.issue10
dc.identifier.pmid20653343
dc.identifier.startpage867
dc.identifier.urihttps://doi.org/10.3109/09553002.2010.487026
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21633
dc.identifier.volume86
dc.identifier.wosWOS:000282519100007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofInternational Journal of Radiation Biology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCauses Bacterial Translocation
dc.subjectPelvic Radiotherapy
dc.subjectEnteral Nutrition
dc.subjectRadiation Enteritis
dc.subjectProctitis Syndrome
dc.subjectCancer-Patients
dc.subjectGut Microflora
dc.subjectBlood-Flow
dc.subjectArginine
dc.subjectGlutamine
dc.titleProphylactic feeding with immune-enhanced diet ameliorates chemoradiation-induced gastrointestinal injury in rats
dc.typeArticle

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