Are P-glycoprotein (ABCB1/MDR1) and endothelial nitric oxide synthase (eNOS) polymorphisms related to severity of the coronary artery disease?

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dc.contributor.authorÖztürk, Ufuk
dc.contributor.authorGazi, Emine
dc.contributor.authorÖzdemir, Öztürk
dc.date.accessioned2025-05-29T05:21:51Z
dc.date.available2025-05-29T05:21:51Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.descriptionBAP -TTU-2014-336
dc.description.abstractBackground/Aim: Atherosclerotic cardiovascular disease is one of the most common causes of morbidity and mortality in developed countries. Genetic and environmental factors are associated with atherosclerosis development. Some single nucleotide polymorphisms have also been directly related to atherosclerosis, for example, polymorphisms that reduce nitric oxide (NO) levels and/or activity have been linked to atherosclerotic diseases. However, the multidrug resistance gene 1 (MDR-1) polymorphism is related to repeated cardiovascular events. This study aimed to investigate the relationship between MDR-1 and endothelial NO synthase (e-NOS) polymorphism and severe coronary artery disease (CAD). Methods: In total, 90 patients presenting with acute coronary syndrome were included in this cross-sectional study. Patients with at least > 70% stenosis in ≥ 2 coronary vessels were defined as severe CAD (Group 1), while those with this same level of involvement in < 2 vessels were diagnosed with single-vessel disease (Group 2). MDR 3435C-T and eNOS T-786C were determined by polymerase chain reaction (PCR) amplification. Comparison of parametric and nonparametric values between the two groups was performed using the Student’s t- or Mann–Whitney U test. Categorical variables were analyzed using the χ2 test. Risk estimations for the association of severe CAD with the polymorphisms were calculated using odds ratio (OR) and 95% confidence intervals by comparing the genotypic combinations. Results: Baseline demographic parameters were similar in both groups, except for the presence of DM and glucose level. T allele of MDR was 42% and 40% in groups 1 and 2, respectively (OR = 1.12). The C allele of eNOS was 34% and 30% in groups 1 and 2, respectively (OR = 1.16). Fourteen and 15 patients (40% and 27%, respectively) had both T and C alleles in patients in groups 1 and 2, respectively (OR = 1.77). All P-values were > 0.05. Conclusion: This study is the first one that shows that MDR1 and e-NOS polymorphisms are frequent in patients with ≥ 2 vessel disease and may be associated with severe CAD.
dc.description.sponsorshipFunding for this research was provided by Scientific Research Foundation Unit (BAP) of Canakkale Onsekiz Mart University, Canakkale-Turkey
dc.identifier.doi10.28982/josam.913769
dc.identifier.endpage435
dc.identifier.issn2602-2079
dc.identifier.issue4
dc.identifier.startpage432
dc.identifier.urihttps://doi.org/10.28982/josam.913769
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30814
dc.identifier.volume6
dc.language.isoen
dc.publisherSelçuk BAŞAK
dc.relation.ispartofJournal of Surgery and Medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250529
dc.subjectMDR-1
dc.subjecteNOS
dc.subjectCoronary artery disease
dc.subjectPolymorphism
dc.subjectP-glycoprotein
dc.titleAre P-glycoprotein (ABCB1/MDR1) and endothelial nitric oxide synthase (eNOS) polymorphisms related to severity of the coronary artery disease?
dc.typeResearch Article

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