Prevalence, antibiotic and pulsed-field gel electrophoresis patterns of Staphylococcus aureus small-colony variants in cystic fibrosis patients

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dc.contributor.authorPakasticali, Nagehan
dc.contributor.authorKaya, Gamze
dc.contributor.authorSenel, Unal
dc.contributor.authorKipritci, Oner
dc.contributor.authorTamay, Zeynep
dc.contributor.authorGuler, Nermin
dc.contributor.authorNazik, Hasan
dc.date.accessioned2025-01-27T19:04:11Z
dc.date.available2025-01-27T19:04:11Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractStaphylococcus aureus is the most common pathogen isolated from respiratory tract samples in cystic fibrosis (CF) cases. Rate of infection with S. aureus small-colony variants (SCVs) also is increasing in CF patients. In this study, we aimed to determine the prevalence, antibiotic susceptibility and genotypic property of S. aureus SCVs in respiratory tract samples of CF patients admitted to Istanbul Faculty of Medicine Hospital, Turkey. Among 305 respiratory tract samples from 84 CF patients, normal S. aureus isolates were present in 71% of the CF patients and S. aureus SCVs in 21%. The highest antibiotic resistance was against penicillin (82%) followed by clarithromycin (21%) in S. aureus SCVs, while resistance to levofloxacin was low (2%) in normal S. aureus isolates but was 16% in S. aureus SCVs. No mecA and mecC were detected. The S. aureus strains constituted 24 different genotypes based on pulsed field gel-electrophoresis assay. The possible existence of S. aureus SCVs that are more resistant to antibiotis than normal S. aureus should be taken into considerstion when treating CF patients for this pernicious bacterial infection. © 2017, SEAMEO TROPMED Network. All Rights Reserved.
dc.identifier.endpage484
dc.identifier.issn0125-1562
dc.identifier.issue3
dc.identifier.pmid27405131
dc.identifier.scopus2-s2.0-84982182685
dc.identifier.scopusqualityQ4
dc.identifier.startpage475
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13853
dc.identifier.volume47
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSEAMEO TROPMED Network
dc.relation.ispartofSoutheast Asian Journal of Tropical Medicine and Public Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subjectCystic fibrosis patient; Genotypic propperty; Small-colony variant; Staphylococcus aureus
dc.titlePrevalence, antibiotic and pulsed-field gel electrophoresis patterns of Staphylococcus aureus small-colony variants in cystic fibrosis patients
dc.typeArticle

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