In vivo biocompatibility of radiation crosslinked acrylamide copolymers

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dc.authoridSaraydin, Dursun/0000-0001-7191-510X
dc.authoridKaradag, Erdener/0000-0003-2208-1676
dc.contributor.authorSaraydin, D
dc.contributor.authorÜnver-Saraydin, S
dc.contributor.authorKaradag, E
dc.contributor.authorKoptagel, E
dc.contributor.authorGüven, O
dc.date.accessioned2025-01-27T21:01:33Z
dc.date.available2025-01-27T21:01:33Z
dc.date.issued2004
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn vitro swelling and in vivo biocompatibility of radiation crosslinked acrylamide copolymers such as acrylamide/crotonic acid (AAm/CA) and acrylamide/itaconic acid (AAm/IA) were studied. The swelling kinetics of acrylamide copolymers were performed in distilled water, human serum and some simulated physiological fluids such as phosphate buffer, pH 7.4, glycine-HCl buffer, pH 1.1, physiological saline solution, and some swelling and diffusion parameters have been calculated. AAm/CA and AAm/IA hydrogels were subcutaneously implanted in rats for up to 10 weeks and the immediate short- and long-term tissue response to these implants were investigated. Histological analysis indicated that tissue reaction at the implant site progressed from an initial acute inflammatory response. No necrosis, tumorigenesis or infection was observed at the implant site up to 10 weeks. The radiation crosslinked AAm/CA and AAm/IA copolymers were found well tolerated, non-toxic and highly biocompatible. However, AAm/IA copolymer was not found to be compatible biomaterials, because one of the AAm/IA samples was disintegrated into small pieces in the rat. (C) 2003 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.nimb.2003.09.035
dc.identifier.endpage292
dc.identifier.issn0168-583X
dc.identifier.issue2
dc.identifier.startpage281
dc.identifier.urihttps://doi.org/10.1016/j.nimb.2003.09.035
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27091
dc.identifier.volume217
dc.identifier.wosWOS:000220143000009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofNuclear Instruments & Methods in Physics Research Section B-Beam Interactions With Materials and Atoms
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectradiation
dc.subjectacrylamide
dc.subjectbiocompatibility
dc.subjectbiomaterial
dc.subjecthydrogel
dc.titleIn vivo biocompatibility of radiation crosslinked acrylamide copolymers
dc.typeArticle

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