Multi-component preparation of indeno[2',1':5,6]pyrido[2,3-d]pyrimidine and reduction reaction

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dc.contributor.authorBerber, Nurcan
dc.date.accessioned2025-01-27T19:05:54Z
dc.date.available2025-01-27T19:05:54Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPyrimidine and their derivatives play an important role in the field of pharmacological activity. Also, pyrimidine compounds containing pyrido pyrimidine structure show significant biological and pharmaceutical activities. In this study, indeno [2',1':5,6]pyrido[2,3-d]pyrimidine derivative was synthesized by the one-pot condensation. This one-pot, three-component condensation took place under mild conditions; 1,3-Indandione (indanedione) (l), 6-amino uracil (2), 4-nitro benzaldehyde (3) in DMF/Et3N at 60 °C. The reaction was completed after 24 h. Also, eight different methods were tried for the reduction of aryl nitro group. For the selective reduction of aryl nitro group in a good yields was used under elemental sulfur (S8), sodium sulphide (Na2S) in THF/water at 100 °C conditions. All coumpounds were characterized by spectroscopic techniques. © by PSP
dc.identifier.endpage513
dc.identifier.issn1018-4619
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85091912442
dc.identifier.scopusqualityN/A
dc.identifier.startpage509
dc.identifier.urihttps://hdl.handle.net/20.500.12428/14037
dc.identifier.volume29
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherParlar Scientific Publications
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subject1; 3-d]pyrimidine; 3-indandi-one; 6-amino uracil; One-pot reaction; Pyrido[2; Reduction reaction
dc.titleMulti-component preparation of indeno[2',1':5,6]pyrido[2,3-d]pyrimidine and reduction reaction
dc.typeArticle

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