Effects of esmolol, lidocaine and fentanyl on P wave dispersion, QT, QTc intervals and hemodynamic responses to endotracheal intubation during propofol induction: a comparative study

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dc.authoridozkocak turan, isil/0000-0002-0405-0107
dc.authoridErdogan Kayhan, Gulay/0000-0002-2635-9295
dc.authoridBuyukuysal, Mustafa Cagatay/0000-0001-9810-5633
dc.authoridHanci, Volkan/0000-0002-2227-194X
dc.contributor.authorHanci, Volkan
dc.contributor.authorYurtlu, Serhan
dc.contributor.authorKarabag, Turgut
dc.contributor.authorOkyay, Dilek
dc.contributor.authorHakimoglu, Sedat
dc.contributor.authorKayhan, Gulay
dc.contributor.authorBuyukuysal, Cagatay
dc.date.accessioned2025-01-27T21:03:35Z
dc.date.available2025-01-27T21:03:35Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground and objectives: In our study we aimed to investigate the effect of esmolol, lidocaine and fentanyl on P-wave dispersion (Pwd), QT and corrected QT (QTc) durations and hemodynamic responses to endotracheal intubation during propofol induction. Methods: A total of eighty adult patients, American Society of Anesthesiologists (ASA) Physical Status I or II aged 18 to 60 years were included in this prospective, randomised, double-blind study. All patients had control electrocardiograms (ECGs) done before anesthesia induction. The patients were randomised into four equal groups. The control group (Group C) received saline 5 mL, the esmolol group (Group E) received esmolol 0.5 mg.kg(-1), the fentanyl group (Group F) received fentanyl 2 mu g.kg(-1) and the lidocaine group (Group L) received lidocaine 1.5 mg.kg(-1) before anesthesia induction. Anesthesia was induced with intravenous propofol. ECGs for all patients were performed during the 1st and 3rd minutes of induction, 3 minutes after administration of muscle relaxant, and at 5 minutes and 10 minutes after intubation. Pwd and QT intervals were measured on all ECGs. QTc intervals were determined using the Bazett formula. Heart rate (HR) and mean arterial pressure (MAP) were recorded before and after induction of anesthesia, immediately after intubation, and 1, 3, 5, 7 and 10 minutes after intubation. Results: Compared with control, HR significantly increased in Group C, Group Land Group F after intubation. However, in Group E, there was no significant difference in HR values between control and after intubation. Compared with control, MAP significantly increased in Group C and Group L after the intubation. However, in Group E and Group F, there was no significant difference in MAP values between control and after the intubation. Compared with control, Pwd significantly increased in Group C after intubation. In Group L, Group F and Group E, there was no significant difference in Pwd values between control and after the intubation. Compared with control, QTc duration significantly increased in Group C and L after the intubation. In Group F and Group E, there was no significant difference in QTc durations between control and after the intubation. Conclusion: We concluded that administration of esmolol before intubation prevents tachycardia and an increase in MAP, Pwd and QTc duration caused by laryngoscopy and tracheal intubation. (C) 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.
dc.identifier.doi10.1590/S0034-70942013000300001
dc.identifier.endpage244
dc.identifier.issn0034-7094
dc.identifier.issn1806-907X
dc.identifier.issue3
dc.identifier.pmid23683444
dc.identifier.startpage235
dc.identifier.urihttps://doi.org/10.1590/S0034-70942013000300001
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27354
dc.identifier.volume63
dc.identifier.wosWOS:000320092500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofRevista Brasileira De Anestesiologia
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectElectrocardiography
dc.subjectIntubation, Intratracheal
dc.subjectAnesthesia
dc.subjectPropanolamines/esmolol
dc.subjectLidocaine
dc.subjectFentanyl
dc.subjectPropofol
dc.titleEffects of esmolol, lidocaine and fentanyl on P wave dispersion, QT, QTc intervals and hemodynamic responses to endotracheal intubation during propofol induction: a comparative study
dc.typeArticle

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