HEPCIDIN AND VITAMIN D LEVELS: MUTUAL EFFECTS IN ANEMIA OF CHRONIC KIDNEY DISEASE

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dc.contributor.authorUstuner, Berna
dc.contributor.authorBek, Sibel Gökçay
dc.contributor.authorEren, Necmi
dc.contributor.authorBakirdogen, Serkan
dc.contributor.authorKalender, Betül Gönüllü
dc.date.accessioned2025-01-27T19:30:45Z
dc.date.available2025-01-27T19:30:45Z
dc.date.issued2021
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Hepcidin is a peptide with anti-microbial properties that is largely synthesized in the liver and has important roles in iron homeostasis,with serum levels elevated in chronic inflammatory conditions, including chronic kidney disease (CKD). Our aim was to discuss on the role ofvitamin D in regulation of hepcidin and anemia of CKD.Methods: The study group included 103 patients with CKD and 59 healthy individuals. The serum concentration of hepcidin was measured usingELISA, and the association to the following factors was evaluated: age, sex, body mass index, renal functions (estimated glomerular filtration rate,eGFR), drug history, serum biochemistry, complete blood count, iron and total iron binding capacity, ferritin, vitamin D, high sensitive C-reactiveprotein, C-reactive protein, and the erythrocyte sedimentation rate.Results: The mean age of the CKD group was 58.63 ± 11.8 years (with 16, 26, 27, 19, and 15 patients; respectively in each chronic kidney diseasestage, from I through V and nine on haemodialysis, six on peritoneal dialysis). The mean hepcidin concentration was higher in the chronic kidneydisease (30.3±24.7 ng/ml) than control (17.8 ± 8.4ng/ml) group (p<0.05). There was a positive association between hepcidin and CRP, ESR and thefollowing serum factors (urea, creatinine, ferritin, phosphate, pH, parathyroid hormone and alkaline phosphatase), with a negative association witheGFR, haemoglobin, haematocrit, calcium, magnesium, 25-OH vitamin D and bicarbonate levels.Conclusion: Hepcidin levels were found negatively correlated with 25-OH vitamin D levels which was related with the inflammatory effects ofvitamin D and hepcidin.
dc.identifier.doi10.30934/kusbed.661316
dc.identifier.endpage114
dc.identifier.issn2149-8571
dc.identifier.issue2
dc.identifier.startpage110
dc.identifier.trdizinid459780
dc.identifier.urihttps://doi.org/10.30934/kusbed.661316
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/459780
dc.identifier.urihttps://hdl.handle.net/20.500.12428/16240
dc.identifier.volume7
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofKocaeli Üniversitesi Sağlık Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectEndokrinoloji ve Metabolizma
dc.subjectGenel ve Dahili Tıp
dc.subjectHematoloji
dc.subjectSağlık Bilimleri ve Hizmetleri
dc.titleHEPCIDIN AND VITAMIN D LEVELS: MUTUAL EFFECTS IN ANEMIA OF CHRONIC KIDNEY DISEASE
dc.typeArticle

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