Effect of Mediterranean Mussels (Mytilus galloprovincialis) From Polluted Areas on Hepatotoicity in Rats by Immunuhistochemical Method

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dc.contributor.authorİrkin, Latife Ceyda
dc.contributor.authorÇakına, Suat
dc.contributor.authorÖzdemir, İlhan
dc.contributor.authorÖztürk, Şamil
dc.date.accessioned2025-01-27T19:26:22Z
dc.date.available2025-01-27T19:26:22Z
dc.date.issued2021
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractMussels (Mytilus galloprovincialis) are aquatic organisms that can accumulate all the factors that pollute the fresh andsaltwater environment. Although the Dardanelles has been exposed to environmental pollution for many years, it is also animportant region for crustaceans. We aimed to investigate the histopathological changes in the liver parenchyma which is animportant gland of the digestive system by feeding these mussels to rats. Twenty-four male Wistar albino were used in thestudy. The first group (control): fed with standard rat feed, the second group (experiment 1): 4/5 mussel + 1/5 standard ratfeed daily; third group (experiment 2): 4/5 mussel + 1/5 standard rat feed every other day, the fourth group (experiment 3):groups were formed with 4/5 mussel + 1/5 standard rat feed every three days. All liver tissue samples taken from theexperimental and control groups were stained with hematoxylin-eosin, and immuohitochemically staining inflammatorymarker TNF-? and NF-?B after routine histopathological follow-up and analyzed with a light microscope image analysissystem. It was observed that mononuclear cells caused inflammation of portal areas, increased sinusoidal dilatation andcongestion and degeneration due to vacuolization in hepatocytes in the liver parenchyma of mussel-fed rats. Besides,immunohistochemical staining, TNF-?, and NF-?B immunoreactivity were observed in the liver cells of especially in thesecond group of rats. As a result, it has been shown that the consumption of mussels obtained and marketed withoutconsidering environmental pollution may trigger important digestive system organs of liver diseases.
dc.identifier.doi10.22392/actaquatr.762038
dc.identifier.endpage118
dc.identifier.issn2651-5474
dc.identifier.issue1
dc.identifier.startpage108
dc.identifier.trdizinid434442
dc.identifier.urihttps://doi.org/10.22392/actaquatr.762038
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/434442
dc.identifier.urihttps://hdl.handle.net/20.500.12428/15442
dc.identifier.volume17
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofActa Aquatica Turcica
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectBiyoloji
dc.subjectHalk ve Çevre Sağlığı
dc.subjectGenel ve Dahili Tıp
dc.subjectPatoloji
dc.subjectÇevre Bilimleri
dc.titleEffect of Mediterranean Mussels (Mytilus galloprovincialis) From Polluted Areas on Hepatotoicity in Rats by Immunuhistochemical Method
dc.typeArticle

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