Associations of fractalkine receptor (CX3CR1) and CCR5 gene variants with hypertension, diabetes and atherosclerosis in chronic renal failure patients undergoing hemodialysis

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dc.authoridbagci, binnur/0000-0003-1323-3359
dc.authoridBagci, Gokhan/0000-0003-4554-2391
dc.contributor.authorBagci, Binnur
dc.contributor.authorBagci, Gokhan
dc.contributor.authorHuzmeli, Can
dc.contributor.authorSezgin, Ilhan
dc.contributor.authorÖzdemir, Öztürk
dc.date.accessioned2025-01-27T20:53:50Z
dc.date.available2025-01-27T20:53:50Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractWe aimed to investigate the associations of fractalkine receptor (CX3CR1) V249I, T280M and CCR5-59029 A/G gene polymorphisms in chronic renal failure (CRF) subjects undergoing hemodialysis and to evaluate possible associations of these polymorphisms with hypertension (HT), diabetes mellitus (DM) and atherosclerosis (AS). A total of 225 CRF subjects undergoing hemodialysis and 201 healthy controls were enrolled in the study. CRF subjects were divided into three major subgroups according to comorbidities including HT (n = 127), DM (n = 65) and AS (n = 33). Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism method. The II genotype and I allele frequencies of CX3CR1 V249I polymorphism were found significantly more frequent in CRF subjects, CRF subjects with DM and CRF subjects with AS compared with controls (p < 0.05 for all comparisons). G allele frequency of CCR5 polymorphism was found significantly more prevalent in CRF subjects with DM than that of controls. Further, GG genotype and G allele frequencies of CCR5 polymorphism were significantly more prevalent in CRF subjects with AS compared with controls (p < 0.05). We also explored these polymorphisms among CRF subjects with and without following comorbidities: HT, DM, AS. We found significant association between CRF subjects with HT and without HT in terms of genotype and allele frequencies of V249I polymorphism (p < 0.05). CX3CR1 T280M polymorphism was not found significantly different in none of the comparisons. These data demonstrate possible associations between CX3CR1 V249I and CCR5-59029 A/G polymorphisms and/or HT, DM and AS in CRF subjects.
dc.identifier.doi10.1007/s11255-016-1293-0
dc.identifier.endpage1170
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue7
dc.identifier.pmid27118566
dc.identifier.startpage1163
dc.identifier.urihttps://doi.org/10.1007/s11255-016-1293-0
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25863
dc.identifier.volume48
dc.identifier.wosWOS:000378888900021
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Urology and Nephrology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectChronic renal failure
dc.subjectCCR5
dc.subjectCX3CR1
dc.subjectHypertension
dc.subjectDiabetes mellitus
dc.subjectAtherosclerosis
dc.subjectPolymorphism
dc.titleAssociations of fractalkine receptor (CX3CR1) and CCR5 gene variants with hypertension, diabetes and atherosclerosis in chronic renal failure patients undergoing hemodialysis
dc.typeArticle

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