PREVALENCE, ANTIBIOTIC AND PULSED-FIELD GEL ELECTROPHORESIS PATTERNS OF STAPHYLOCOCCUS AUREUS SMALL-COLONY VARIANTS IN CYSTIC FIBROSIS PATIENTS

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dc.contributor.authorPakasticali, Nagehan
dc.contributor.authorKaya, Gamze
dc.contributor.authorSenel, Unal
dc.contributor.authorKipritci, Oner
dc.contributor.authorTamay, Zeynep
dc.contributor.authorGuler, Nermin
dc.contributor.authorNazik, Hasan
dc.date.accessioned2025-01-27T20:43:44Z
dc.date.available2025-01-27T20:43:44Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractStaphylococcus aureus is the most common pathogen isolated from respiratory tract samples in cystic fibrosis (CF) cases. Rate of infection with S. aureus small-colony variants (SCVs) also is increasing in CF patients. In this study, we aimed to determine the prevalence, antibiotic susceptibility and genotypic property of S. aureus SCVs in respiratory tract samples of CF patients admitted to Istanbul Faculty of Medicine Hospital, Turkey. Among 305 respiratory tract samples from 84 CF patients, normal S. aureus isolates were present in 71% of the CF patients and S. aureus SCVs in 21%. The highest antibiotic resistance was against penicillin (82%) followed by clarithromycin (21%) in S. aureus SCVs, while resistance to levofloxacin was low (2%) in normal S. aureus isolates but was 16% in S. aureus SCVs. No mecA and mecC were detected. The S. aureus strains constituted 24 different genotypes based on pulsed field gel-electrophoresis assay. The possible existence of S. aureus SCVs that are more resistant to antibiotis than normal S. aureus should be taken into considerstion when treating CF patients for this pernicious bacterial infection.
dc.description.sponsorshipIstanbul University Scientific Researches Unit [32591]
dc.description.sponsorshipThis study was supported by Istanbul University Scientific Researches Unit (project no.32591). The authors thank Dr Gavin K Paterson for providing LGA251, mecC-positive MRSA.
dc.identifier.endpage484
dc.identifier.issn0125-1562
dc.identifier.issue3
dc.identifier.pmid27405131
dc.identifier.startpage475
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24354
dc.identifier.volume47
dc.identifier.wosWOS:000378012400015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSoutheast Asian Ministers Educ Organization
dc.relation.ispartofSoutheast Asian Journal of Tropical Medicine and Public Health
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectStaphylococcus aureus
dc.subjectsmall-colony variant
dc.subjectgenotypic propperty
dc.subjectcystic fibrosis patient
dc.titlePREVALENCE, ANTIBIOTIC AND PULSED-FIELD GEL ELECTROPHORESIS PATTERNS OF STAPHYLOCOCCUS AUREUS SMALL-COLONY VARIANTS IN CYSTIC FIBROSIS PATIENTS
dc.typeArticle

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