Decoding Early Mycosis Fungoides: Histopathologic and Immunohistochemical Clues

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dc.contributor.authorTerzi, Neslihan Kaya
dc.date.accessioned2025-01-27T20:57:56Z
dc.date.available2025-01-27T20:57:56Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Primary cutaneous lymphomas, notably mycosis fungoides (MF), present diagnostic challenges in recognizing early mycosis fungoides (eMF) due to their diverse clinical and histopathologic manifestations. The aim of our study was to use adjunctive histopathologic and immunohistochemical methods in eMF cases to make an early diagnosis and to facilitate differentiation from other dermatoses. Methods: This retrospective study analyzed 35 cases of eMF diagnosed at a single center. Demographic and clinicopathologic data were collected, and histopathologic features were assessed. Comparative analyses were conducted with conditions mimicking eMF, including large plaque parapsoriasis (LPP), psoriasis, and chronic dermatitis. Immunohistochemistry for T -cell markers (CD3, CD4, CD8, CD2, CD7) was performed. Results: With the scoring we applied in our study, a sensitivity of 91.43% (95% CI; 76.94% to 98.20%) and specificity of 85.71% (95% CI; 69.74% to 95.19%) for distinguishing eMF from LPP. Epidermotropism emerged as a crucial histopathologic marker, with a notable absence in most cases of cutaneous dermatitis (81.6% and 80% for CD and psoriasis, respectively) (P < 0.001). Immunohistochemistry revealed a T -helper phenotype (CD4+/CD8-) in the majority of eMF cases (78.1%), while CD4+/CD8+ and CD8+/CD4- patterns were less common (28.5% and 8.5%, respectively). Conclusion: This study underscores the complexities in distinguishing eMF from inflammatory skin diseases, advocating for a comprehensive diagnostic approach.
dc.identifier.doi10.7759/cureus.57545
dc.identifier.issn2168-8184
dc.identifier.issue4
dc.identifier.pmid38577165
dc.identifier.urihttps://doi.org/10.7759/cureus.57545
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26557
dc.identifier.volume16
dc.identifier.wosWOS:001207038100035
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofCureus Journal of Medical Science
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectimmunohistochemical markers
dc.subjectdifferential histopathological diagnosis
dc.subjectbenign inflammatory dermatoses
dc.subjectearly stage
dc.subjectmycosis fungoides
dc.titleDecoding Early Mycosis Fungoides: Histopathologic and Immunohistochemical Clues
dc.typeArticle

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