Effects of Lycopene and Vitamine E Administration Over Gastric Mucosal Damage Induced by Aflatoxin B1

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dc.contributor.authorKurt, Dogan
dc.contributor.authorSaruhan, Berna Guney
dc.contributor.authorYokus, Beran
dc.contributor.authorCakir, Dilek Ulker
dc.date.accessioned2025-01-27T20:45:52Z
dc.date.available2025-01-27T20:45:52Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn the present study, we aimed to determine, the changes induced by Aflatoxin B-1 (AFB(1)) administration on rat gastric mucosal barrier and gastric mucins alongside revealing the protective effects of lycopene and Vit E. Thirty-five Wistar-Albino male rats weighing 180-220 g, were divided into 7 groups as to include 5 rats in each group: control, lycopene (10 mg/kg/day lycopene for 15 days (Lycopene 10% FS), AFB(1) (single dose of 2.5 mg AFB(1) kg(-1) on the 12th day of the study), Lycopene + AFB(1) (10 mg lycopene/kg/day for 15 days and single dose of 2.5 mg AFB(1) kg(-1) on the 12th day of the study) and Vitamin E + AFB(1) (10 mg/kg/day Vitamin E for 15 days and single dose 2.5 mg AFB(1) kg(-1) on 12th day). Following the sacrifice of study subjects on the 15th day, gastric mucus and phospholipid levels were determined and their stomachs were examined histopathologically. Examination of mucus and phospholipid levels revealed a significant reduction in group 3-5, in which AFB(1) has been applied (respectively, p<0.001, p<0.001). When lycopene and vitamine E groups are compared with the AFB(1) group, a significant elevation was detected in mucus and phospholipid levels (respectively, p<0.001, p<0.001). Whereas, histopathological examination of gastric mucosas of the aflatoxin group showed degenerative changes, gastric mucosas of the control group and the remaining study groups were normal. Histochemically, while neutral mucins were predominant in general structure of stomach, mixed and sialomucins were observed, as well. Particularly acid mucins with suplhate and periodate reactive acid mucins were found to be more predominant in the aflatoxin group compared to control and other groups. Histochemical features of mucins were observed to be consistent with specific functions of the different regions of stomach. Lycopene and vitamine E administrations were found to be protective against the damage induced by aflatoxin on gastric mucosa.
dc.identifier.endpage1262
dc.identifier.issn1680-5593
dc.identifier.issn1993-601X
dc.identifier.issue7
dc.identifier.startpage1256
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24746
dc.identifier.volume8
dc.identifier.wosWOS:000265889200003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherMedwell Online
dc.relation.ispartofJournal of Animal and Veterinary Advances
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAflatoxin B-1
dc.subjectgastric barrier
dc.subjectLycopene
dc.subjectmucin
dc.subjectrat
dc.titleEffects of Lycopene and Vitamine E Administration Over Gastric Mucosal Damage Induced by Aflatoxin B1
dc.typeArticle

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