Plasma leptin status and the relationship between different medical treatments used in ankylosing spondylitis
dc.contributor.author | Güler, Mustafa | |
dc.contributor.author | Çapkin, Erhan | |
dc.contributor.author | Karkucak, Murat | |
dc.contributor.author | Aydin, Teoman | |
dc.contributor.author | Türkyilmaz, Ayşegül Küçükali | |
dc.contributor.author | Karaca, Adem | |
dc.contributor.author | Gökmen, Ferhat | |
dc.date.accessioned | 2025-01-27T19:04:26Z | |
dc.date.available | 2025-01-27T19:04:26Z | |
dc.date.issued | 2013 | |
dc.department | Çanakkale Onsekiz Mart Üniversitesi | |
dc.description.abstract | Objective: To determine plasma leptin level in ankylosing spondylitis (AS) and its correlation with disease activity measurements. To examine the effects of different treatment modalities on leptin levels. Material and Method: One hundred eight patients diagnosed with AS according to New York Criteria and 65 healthy individuals were enrolled in the study. The Bath AS Disease Activity Index (BASDAI) was used for disease activity. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, acute phase reactants, plasma leptin levels, serum interleukin-6 (IL-6) and serum tumor necrosis factor-? (TNF-?) levels were investigated. Results: Plasma leptin levels in AS patients were statistically significantly lower compared with those in the healthy control group (p=0.003). There was no significant difference among sub-groups established on the basis of medical treatments and disease activity. No statistically significant correlation was determined between leptin level and disease activity parameters, radiological score and functional indices (p>0.05). Conclusion: Plasma leptin was lower in AS patients compared with the control group. This is not correlated with disease activation and medical treatment utilized. | |
dc.identifier.endpage | 113 | |
dc.identifier.issn | 1305-2381 | |
dc.identifier.issue | 2 | |
dc.identifier.scopus | 2-s2.0-84884308616 | |
dc.identifier.scopusquality | Q4 | |
dc.identifier.startpage | 109 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12428/13953 | |
dc.identifier.volume | 9 | |
dc.indekslendigikaynak | Scopus | |
dc.language.iso | en | |
dc.relation.ispartof | Nobel Medicus | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.snmz | KA_Scopus_20250125 | |
dc.subject | Ankylosing spondylitis; Leptin; TNF-? | |
dc.title | Plasma leptin status and the relationship between different medical treatments used in ankylosing spondylitis | |
dc.title.alternative | Ankilozan spondilitli hastalarda uygulanan farkli tedavi şekilleri ile plazma leptin de?erleri arasindaki ilişki | |
dc.type | Article |