Plasma leptin status and the relationship between different medical treatments used in ankylosing spondylitis

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dc.contributor.authorGüler, Mustafa
dc.contributor.authorÇapkin, Erhan
dc.contributor.authorKarkucak, Murat
dc.contributor.authorAydin, Teoman
dc.contributor.authorTürkyilmaz, Ayşegül Küçükali
dc.contributor.authorKaraca, Adem
dc.contributor.authorGökmen, Ferhat
dc.date.accessioned2025-01-27T19:04:26Z
dc.date.available2025-01-27T19:04:26Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: To determine plasma leptin level in ankylosing spondylitis (AS) and its correlation with disease activity measurements. To examine the effects of different treatment modalities on leptin levels. Material and Method: One hundred eight patients diagnosed with AS according to New York Criteria and 65 healthy individuals were enrolled in the study. The Bath AS Disease Activity Index (BASDAI) was used for disease activity. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, acute phase reactants, plasma leptin levels, serum interleukin-6 (IL-6) and serum tumor necrosis factor-? (TNF-?) levels were investigated. Results: Plasma leptin levels in AS patients were statistically significantly lower compared with those in the healthy control group (p=0.003). There was no significant difference among sub-groups established on the basis of medical treatments and disease activity. No statistically significant correlation was determined between leptin level and disease activity parameters, radiological score and functional indices (p>0.05). Conclusion: Plasma leptin was lower in AS patients compared with the control group. This is not correlated with disease activation and medical treatment utilized.
dc.identifier.endpage113
dc.identifier.issn1305-2381
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84884308616
dc.identifier.scopusqualityQ4
dc.identifier.startpage109
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13953
dc.identifier.volume9
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofNobel Medicus
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subjectAnkylosing spondylitis; Leptin; TNF-?
dc.titlePlasma leptin status and the relationship between different medical treatments used in ankylosing spondylitis
dc.title.alternativeAnkilozan spondilitli hastalarda uygulanan farkli tedavi şekilleri ile plazma leptin de?erleri arasindaki ilişki
dc.typeArticle

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