Endothelial nitric oxide synthase levels and their response to exercise in patients with slow coronary flow

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dc.authoridOzyalin, Fatma/0000-0001-6486-6389
dc.authoridEyyupkoca, Ferhat/0000-0003-2630-3619
dc.contributor.authorTasolar, Hakan
dc.contributor.authorEyyupkoca, Ferhat
dc.contributor.authorAkturk, Erdal
dc.contributor.authorKarakus, Yasin
dc.contributor.authorCansel, Mehmet
dc.contributor.authorYagmur, Julide
dc.contributor.authorOzyalin, Fatma
dc.date.accessioned2025-01-27T20:51:58Z
dc.date.available2025-01-27T20:51:58Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Endothelial dysfunction plays a key role in the aetiopathogenesis of slow coronary flow (SCF) even if there is no obstructive epicardial lesion. Reduced plasma levels of endothelial nitric oxide synthase (eNOS) are an important indicator of endothelial dysfunction. We aimed to determine plasma levels of eNOS and their relationship with exercise in patients with SCF. Methods: Twenty-two patients with SCF in at least one coronary artery and 17 healthy individuals were included in this study. The TIMI frame count method was used to determine SCF. Plasma levels of eNOS before and after effort were determined in the patient and control groups. Results: Basal eNOS levels in the patient group were lower than in the control group (p = 0.040), and plasma eNOS levels after exercise decreased more significantly in the patient group compared to the control group (p = 0.002). Median decreases of eNOS in response to exercise were higher in the SCF group than in the control group (p < 0.001), and the decrease observed in the control group was not statistically significant (p = 0.35). There were significantly negative correlations between TIMI frame count and plasma levels of eNOS at baseline and after exercise (r = -0.51, p = 0.015, r = -0.58, p = 0.005, respectively). Moreover, there was also a positive correlation between the rate-pressure product and plasma levels of eNOS after exercise in patients with SCF (r = 0.494, p = 0.019). Conclusion: Our findings indicate an important pathophysiological relationship between the severity of SCF in which endothelial dysfunction plays a role in its pathogenesis and the level of circulating plasma levels of eNOS.
dc.identifier.doi10.5830/CVJA-2013-072
dc.identifier.endpage359
dc.identifier.issn1995-1892
dc.identifier.issn1680-0745
dc.identifier.issue9-10
dc.identifier.pmid24337211
dc.identifier.startpage355
dc.identifier.urihttps://doi.org/10.5830/CVJA-2013-072
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25608
dc.identifier.volume24
dc.identifier.wosWOS:000337256000004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherClinics Cardive Publ Pty Ltd
dc.relation.ispartofCardiovascular Journal of Africa
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectendothelial nitric oxide synthase
dc.subjectslow coronary flow
dc.subjectendothelial dysfunction
dc.subjectexercise
dc.subjectrate-pressure product
dc.titleEndothelial nitric oxide synthase levels and their response to exercise in patients with slow coronary flow
dc.typeArticle

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