ANTIMICROBIAL RESISTANCE PROFILE OF ESCHERICHIA COLI CAUSING BACTEREMIA IN PATIENTS IN INTENSIVE CARE UNITS

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dc.authoridDoganay, Mehmet/0000-0003-3922-4901
dc.contributor.authorDurmaz, Suleyman
dc.contributor.authorKiraz, Asli
dc.contributor.authorPercin, Duygu
dc.contributor.authorDoganay, Mehmet
dc.date.accessioned2025-01-27T20:16:46Z
dc.date.available2025-01-27T20:16:46Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAims: A crucial mechanism of antibiotic resistance of Escherichia coli (E.coli), a member of gram-negative bacteria that cause infections in intensive care units (ICUs), is beta-lactamase production. This study aims to determine extended-spectrum beta-lactamase (ESBL) production frequency and antibiotic resistance profile of E.coli strains isolated from blood cultures of adult patients in different intensive ICUs at Erciyes University-Kayseri, Turkey. Materials and methods: This study includes only one E.coli strain per patient. Antibiotic susceptibility test of 81 E.coli strains were performed using Kirby-Bauer disk diffusion method. ESBL-production was determined using double-disk synergy test. Results: A total of 58 (72%) strains were isolated from patients in internal ICUs while 23 (28%) strains were isolated from patients in surgical ICUs. A total of 44 (54.3%) strains were found to produce ESBL with ESBL-production rate of 55.2% in internal ICUs and 52.2% in surgical ICUs. Difference between the presence of ESBL-producing E.coli in male and female patients in ICUs is not statistically significant. 8 (9.8%), 46(56.8%), 69 (85.2%), 22 (27.2%), and 44 (543%) and zero strains were resistant to amikacine, ciprofloxacine, ampicillin, piperacillin-tazobactam, cefotaxime, and imipenem, respectively, and no strains were resistant to imipenenm. Resistance to amikacin, ciprofloxacin, ampicillin and cefotaxime in ESBL producing strains were significantly higher than ESBL non-producing strains (p<0.05). Piperacillin-tazobactam resistance ratio for E.coli strains isolated from surgical ICUs was found to be significantly greater than those isolated from internal ICUs (p<0.05). Despite higher ratios of ESBL-production of E.coli strains, carbapenem resistance was not gratifyingly determined in the ICUs. Conclusion: Early diagnosis and immediate treatment of nosocomial bacteremia are important for patients' survival. Therefore, monitoring antibiotic susceptibility profiles of isolated microorganisms will guide clinicians for controlling infections.
dc.identifier.endpage637
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue3
dc.identifier.startpage633
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21382
dc.identifier.volume31
dc.identifier.wosWOS:000357001100014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherCarbone Editore
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAntimicrobial drug resistance
dc.subjectBacteremia
dc.subjectEscherichia coli
dc.subjectIntensive care units
dc.titleANTIMICROBIAL RESISTANCE PROFILE OF ESCHERICHIA COLI CAUSING BACTEREMIA IN PATIENTS IN INTENSIVE CARE UNITS
dc.typeArticle

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