CAN MAGNETIC RESONANCE SPECTROSCOPY ADEQUATELY DIFFERENTIATE NEOPLASTIC FROM NON-NEOPLASTIC AND LOW-GRADE FROM HIGH-GRADE LESIONS IN BRAIN MASSES?

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dc.authoriderturk, sukru mehmet/0000-0003-4086-675X
dc.authoridKaratag, Ozan/0000-0002-0606-6364
dc.contributor.authorKaratag, Ozan
dc.contributor.authorKaratag, Gulden Yenice
dc.contributor.authorUysal, Ender
dc.contributor.authorCan, S. Meltem
dc.contributor.authorErturk, Mehmet
dc.contributor.authorBasak, Muzaffer
dc.date.accessioned2025-01-27T21:24:14Z
dc.date.available2025-01-27T21:24:14Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: The aim of this study was to evaluate the usefulness of Magnetic Resonance Spectroscopy in the differential diagnosis of brain lesions. Materials and Methods: Forty-six patients with cerebral lesions were examined by Magnetic Resonance Spectroscopy. Choline, creatine, N-acetyl aspartate and lipid-lactate peaks were evaluated. Forty of the 46 patients underwent stereotactic biopsy or surgery. Histopathological results were compared with the Magnetic Resonance Spectroscopy results. Results: The Choline / N-acetyl aspartate ratio had the highest sensitivity (87.2%) in neoplastic versus nonneoplastic differentiation and the specificities of the Choline / Creatine, Choline / N-acetyl aspartate and Choline+Creatine / N-acetyl aspartate ratios were found to be 100%. Choline / Creatine ratios showed the highest sensitivity (95.7%) in low-grade versus high-grade differentiation and specificities of Choline / N-acetyl aspartate, Choline+Creatine / N-acetyl aspartate ratios and lipid-lactate levels were found to be 100%. Consequently, a value of Choline / Creatine > 2.2 and an accompanying lipid-lactate peak differentiated neoplasms as low-grade versus high-grade with a sensitivity of 100% (82.2-100%) and a specificity of 100% (71.7-100%). Conclusion: The presence of elevated Choline and decreased N-acetyl aspartate levels are effective in the differetiation of neoplastic versus non-neoplastic lesions with high sensitivity and specificity. A proposed ratio of Choline / Creatine > 2.2 and an accompanying lipid-lactate peak provide valuable information in differentiating low-grade from high-grade lesions.
dc.identifier.endpage338
dc.identifier.issn1309-9469
dc.identifier.issue3
dc.identifier.startpage326
dc.identifier.urihttps://hdl.handle.net/20.500.12428/29470
dc.identifier.volume23
dc.identifier.wosWOS:000219982800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherMarmara Univ, Fac Medicine
dc.relation.ispartofMarmara Medical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBrain neoplasms
dc.subjectMagnetic resonance imaging
dc.subjectMagnetic resonance spectroscopy
dc.subjectStereotactic biopsy
dc.titleCAN MAGNETIC RESONANCE SPECTROSCOPY ADEQUATELY DIFFERENTIATE NEOPLASTIC FROM NON-NEOPLASTIC AND LOW-GRADE FROM HIGH-GRADE LESIONS IN BRAIN MASSES?
dc.typeArticle

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