Toxicity of polyvinyl alcohols in medicinal chemistry

dc.contributor.authorDalyan, Orkun
dc.contributor.authorÖztürk, Ömer Faruk
dc.contributor.authorPişkin, Mehmet Burçin
dc.date.accessioned2025-01-27T19:36:47Z
dc.date.available2025-01-27T19:36:47Z
dc.date.issued2021
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPolyvinyl alcohol (Chemical Abstracts Service No: 9002-89-5), biodegradable, biocompatible, water-soluble, odorless, tasteless, transparent, white to creamy granular or powder appearance, and is a synthetic hydroxy polymer used in a broad variety of industrial, trading, medicinal and food implementations. The aim of this review is to back the safety of polyvinyl alcohol qua a coating agent for medicinal chemistry and dietary addition products, considering the current knowledge of polyvinyl alcohol. All available information on polyvinyl alcohol obtained from a comprehensive scientific literature review was seriously evaluated. Orally directed polyvinyl alcohol is comparatively harmless. The safety of polyvinyl alcohol when directed orally is based on: (a) Acute oral toxicity LD50 rates are in the range of 14.7–20 g/kg, very low, (b) is very poorly absorbed from the digestive system, (c) does not accumulate in the body, (d) the highest levels of polyvinyl alcohol with no observed adverse effects when directed orally in male and female rats, 5000 mg / kg body weight / day in a 90-day diet survey as the highest dose tested and 5000 mg / kg body weight / day was found in two generation reproductive studies.
dc.identifier.doi10.51354/mjen.918635
dc.identifier.endpage135
dc.identifier.issn1694-7398
dc.identifier.issue2
dc.identifier.startpage129
dc.identifier.trdizinid488834
dc.identifier.urihttps://doi.org/10.51354/mjen.918635
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/488834
dc.identifier.urihttps://hdl.handle.net/20.500.12428/16987
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofManas Journal of Engineering
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectKimya
dc.subjectTıbbi
dc.subjectToksikoloji
dc.subjectFarmakoloji ve Eczacılık
dc.titleToxicity of polyvinyl alcohols in medicinal chemistry
dc.typeReview Article

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