The role of ischemia-modified albumin, high sensitivity troponin T, and other inflammatory markers in early diagnosis of acute coronary syndrome in patients presenting to the emergency department with chest pain

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dc.authoridAkman, Canan / 0000-0002-3427-5649
dc.contributor.authorÇetinkaya, Yasemin
dc.contributor.authorAkman, Canan
dc.date.accessioned2026-02-03T11:59:42Z
dc.date.available2026-02-03T11:59:42Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: Early diagnosis of acute coronary syndrome (ACS) is crucial in emergency medicine. While high-sensitivity troponin (hs-Tn) is a key biomarker, its limitations in the early phase highlight the need for additional markers. Ischemia-modified albumin (IMA) has shown potential in detecting myocardial ischemia, but its clinical value remains uncertain. Materials and Methods: Patients presenting with chest pain within three hours were included. Serum IMA and hs-Tn levels were measured, and their combined diagnostic value was assessed. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were also analyzed. Results: IMA levels were significantly higher in ACS patients than in non-ACS cases (p < 0.05). ROC curve analysis showed that IMA alone had moderate diagnostic performance, but its combination with hs-Tn improved sensitivity and specificity. In the ACS group, IMA levels correlated with hs-Tn, particularly in patients with ST-elevation myocardial infarction (STEMI). NLR and PLR showed no significant differences between ACS and non-ACS patients, confirming their limited diagnostic value. Discussion: IMA appears to be a promising biomarker for early ACS detection, especially when combined with hs-Tn. This combination could enhance diagnostic accuracy and support early clinical decision-making. Conversely, NLR and PLR were not reliable indicators of ACS. Further research is needed to confirm these findings and explore the clinical applications of IMA in emergency settings.
dc.identifier.doi10.4328/ACAM.22625
dc.identifier.endpage871
dc.identifier.issn2667-663X
dc.identifier.issue12
dc.identifier.startpage867
dc.identifier.urihttps://doi.org/10.4328/ACAM.22625
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34388
dc.identifier.volume16
dc.identifier.wosWOS:001629943700006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherBayrakol Medical
dc.relation.ispartofAnnals of Clinical and Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectischemia-modified albumin
dc.subjectacute coronary syndrome
dc.subjecthigh-sensitivity troponin
dc.subjectbiomarkers
dc.titleThe role of ischemia-modified albumin, high sensitivity troponin T, and other inflammatory markers in early diagnosis of acute coronary syndrome in patients presenting to the emergency department with chest pain
dc.typeArticle

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