The molecular etiological parameters in thyroid cancer
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Tarih
2014
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cumhuriyet University, Faculty of Medicine
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Thyroid cancer is a common endocrine malignancy its prevelance is increasing worldwide. Currently, the application of molecular technologies has focused on etiological parameters for the accurate diagnosis and therapy of thyroid cancer. Until now in this issue many molecular and immunohistochemical parameters have been reported. Recent literature show that strong association between genetic parameters and thyroid cancer. Initiation and progression of thyroid cancers arise as the consequence of multiple genetic and epigenetic alterations such as; structural point mutations, chromosomal rearrangements and epigenetic events that activate proto-oncogenes and inactivate tumor suppressor genes. There are lots of various tumor-suppressor genes are epigenetically silenced in thyroid cancers. Gain-of-function for proto-oncogenes and loss-of-function for tumour supressor genes have a crucial role in the initiation and/or progression of the thyroid carcinogenesis. The determining of somatic and/or germline molecular alterations have been recognized as helpful diagnostic and prognostic markers and valuable tools for the management of tumoural/nontumuoral nodules in thyroid cancer patients. Known details about those molecular etiological parameters provide further research and clinical development targets, novel diagnostic and therapeutic strategies for thyroid cancers treatment. Current article reviews the molecular etiological alterations in thyroid cancer that help identify relevant biologic pathways to drive cancer development. Direct and undirect moleculer ethiological parametes and action mechanisims that play crucial role in the thyroid cancers widely reviewed in the currenr report. © 2014, Cumhuriyet University, Faculty of Medicine. All rights reserved.
Açıklama
Anahtar Kelimeler
Diagnosis; Molecular markers; Prognosis; Thyroid cancer
Kaynak
Cumhuriyet Medical Journal
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
36
Sayı
1
