Genotoxicity of pyrethrin misuse as chamomile substitute

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dc.contributor.authorCicekliyurt, Merve M.
dc.contributor.authorAkkus, Gulsum
dc.contributor.authorTufan, Begum Dermenci
dc.contributor.authorIpek, Hande
dc.contributor.authorYalcin, Sibel Oymak
dc.date.accessioned2025-01-27T20:41:00Z
dc.date.available2025-01-27T20:41:00Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: Chrysanthemum cinerariaefolium is a white-yellow, daisy-like plant known for more than one hundred fifty years of insecticide property. Although active ingredients of Chrysanthemum cinerariaefolium, pyrethrin is less toxic than organophosphate insecticides, adverse effects on immune system have been demonstrated in numerous animal studies. In our study, the genotoxic potential of accidental consumption (by mixing or unintentional causes) of Chrysanthemum cinerariaefolium instead of chamomile (Matricaria recutita) is investigated. Material and Methods: Lymphocyte isolation was performed from five male, five female donors from peripheral blood samples. Cytotoxic and genotoxic effects of pyrethrin were investigated in human peripheral lymphocyte cultures with chromosome abnormalities (CA). Micronucleus (MN), mitotic index (MI), and nucleus division index (NDI) were calculated. Cultures were treated with mixed doses of pyrethrin and chamomile in different ratios. Results: All doses compared with negative control MN, binucleate, tetranucleate, and MI were significantly increased. In the MN assay, micronucleus formation has been increased due to the gradual increase of pyrethrin/chamomile concentration. In chromosome anomaly test, results differed compared with negative and positive control, and in 24 and 48-hour applications of 1/1 mixed pyrethrin and chamomile samples were founded genotoxically. Discussion: As a result, we have observed pyrethrin has dose-related toxicity increase within the combination. We conclude that the effect of long-term accidental consumption trigger MN, binucleate, tetranucleate formation together with chromosome and chromatin type aberrations.
dc.description.sponsorshipScientific Research Coordination Unit [TSA-2018-2673]; Canakkale Onsekiz Mart University
dc.description.sponsorshipCanakkale Onsekiz Mart University, The Scientific Research Coordination Unit, Project number: TSA-2018-2673.
dc.identifier.doi10.4328/ACAM.22021
dc.identifier.endpage535
dc.identifier.issn2667-663X
dc.identifier.issue8
dc.identifier.startpage531
dc.identifier.urihttps://doi.org/10.4328/ACAM.22021
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23959
dc.identifier.volume15
dc.identifier.wosWOS:001284430000003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherBayrakol Medical Publisher
dc.relation.ispartofAnnals of Clinical and Analytical Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectToxicology
dc.subjectGenotoxicity
dc.subjectChromosome Aberration
dc.subjectMicronucleus
dc.titleGenotoxicity of pyrethrin misuse as chamomile substitute
dc.typeArticle

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