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    Serum Ischemia-Modified Albumin Levels in Experimental Model of Acute Pancreatitis
    (Coll Physicians & Surgeons Pakistan, 2015) Topaloglu, Naci; Kucuk, Adem; Tekin, Mustafa; Yildinm, Sule; Erbas, Mesut; Kiraz, Hasan All; Cakir, Dilek Ulker
    Objective: To establish whether the Ischemia-Modified Albumin (IMA), a new parameter of oxidative stress, has diagnostic role in experimental acute pancreatitis. Study Design: Randomized controlled trial. Place and Duration of Study: Experimental Animal Center, Canakkale Onsekiz Mart University, Canakkale, Turkey, from May to September 2013. Methodology: Sixteen Sprague-Dawley rats were randomly divided into two groups (n=8 each): Sham and AP groups. AP was induced by ligation of pancreatic duct. Serum IMA, amylase, lipase, AST, ALT and CRP were determined. The severity of pancreatitis was scored by a blinded pathologist under microscope. Results: Serum IMA levels in the AP group increased significantly compared with the control group (p < 0.05). There was also a strong positive correlation between amylase and IMA levels. Conclusion: The present study showed in a rodent model that serum IMA might serve as an additional marker to monitor inflammation during pancreatitis.