Yazar "Ulusoy, Seyhan" seçeneğine göre listele

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    Antibacterial and antibiofilm activities of sodium ibuprofen- and paracetamol-loaded nanofibers
    (Society of Chemists and Technologists of Macedonia, 2023) Alkan, Gürkan; Ulusoy, Seyhan; Akgün, Mert; Oral, Ayhan
    Nanofibers loaded with pharmaceutical agents for various medical purposes have become more important in recent years because of their advantages, such as control on release, gas permeability, high surface area, and lightweight matrices. In the present study, polylactic acid (PLA)-gelatin (Gel) nano-fibers were successfully loaded with Ibuprofen-Na/Paracetamol (henceforth Ibu-Na and Par, respectively) by electrospinning. The nanofibers were characterized by scanning electron microscopy (SEM) and Fou-rier transform infrared (FTIR) spectroscopy. The Ibu-Na/Par content of the nanofibers was determined by using high-performance liquid chromatography (HPLC). Their antibacterial activities were tested against Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa PA01, opportunistic pathogenic bacteria which are frequently asso-ciated with infections. Moreover, their antibiofilm activities against P. aeruginosa and E. faecalis were also investigated. The Ibu-Na-containing nanofibers exhibited antibacterial activity against S. aureus, E. coli, and E. faecalis. The inhibition zone diameters of PLA-Gel-Ibu-Na 300 against E. faecalis, S. aureus, and E. coli were calculated to be 23.0 ± 2.1 mm, 18.0 ± 1.5 mm, and 12.0 ± 1.2 mm, respectively. It was found that PLA-Gel-Ibu-Na 300 and PLA-Gel-Par 300 nanofibers’ capacity to show biofilm formation inhibition originated remarkable effects on P. aeruginosa, which were found to be 48 % and 50.4 %, respectively. This study indicated that Ibu-Na/Par-loaded nanofibers are promising materials for wound healing applications.
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    Cinnamaldehyde-poly (lactic acid)/gelatin nanofibers exhibiting antibacterial and antibiofilm activity
    (Taylor & Francis Ltd, 2024) Akpinar, Zeynep; Ulusoy, Seyhan; Akgun, Mert; Oral, Ayhan; Suner, Salih Can
    Bacterial infections and biofilms are known to impede the wound-healing process. Naturally derived compounds from plants hold promise in inhibiting or preventing bacterial biofilms, with cinnamaldehyde (CA) being recognized for its antibacterial and antibiofilm properties. In this investigation, three-dimensional, antibacterial, and biodegradable nanofibers were synthesized via electrospinning, employing FDA-approved polylactic acid (PLA), gelatin (Gel), and the phytoactive molecule cinnamaldehyde (CA). The cinnamaldehyde content, morphology, and physical as well as biological characteristics of the electrospun PLA-Gel-CA nanofibers were scrutinized using HPLC, SEM, TGA, and FTIR analysis. The antibacterial activity of the PLA-Gel-CA nanofibers against Staphylococcus aureus and Pseudomonas aeruginosa, along with their antibiofilm activity against P. aeruginosa, were evaluated. The average diameters of PLA-Gel-CA nanofibers, specifically PLA-Gel-CA1, PLA-Gel-CA2, and PLA-Gel-CA3, were determined to be 294.9 +/- 46.8 nm, 254 +/- 58.3 nm, and 728.5 +/- 98.3 nm, respectively. PLA-Gel-CA3 nanofibers demonstrated notable antibacterial efficacy against S. aureus (31.0 +/- 1.20 mm) and P. aeruginosa (16.0 +/- 1.20 mm), along with a significant inhibition of P. aeruginosa biofilm formation by 72.2%. These findings indicate the potential of cinnamaldehyde-loaded nanofibers for wound application owing to their antibacterial and antibiofilm activity, as well as their rapid dissolution characteristics.
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    Natural-based polymers for antibacterial treatment of absorbent materials
    (Wiley, 2020) Kaplan, Sibel; Aslan, Selcuk; Ulusoy, Seyhan; Oral, Ayhan
    In this study, polypropylene (PP) nonwoven fabric which can be used as topsheet layer of an absorbent hygienic product was modified by natural based antibacterial agents. Antibacterial herbal agents (cinnamaldehyde, geraniol, phenylethyl alcohol) were sprayed by ethanol or applied by means of polylactic acid (PLA) and polycyclohexene oxide (PCHO) based polymers prepared by three different chemical methods. Characterization of synthesized materials was conducted via thermogravimetric analysis (TGA), differential thermal analysis (DTA), and scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDX). Besides characterization, antibacterial and pH buffering performances of antibacterial polymers alone and on PP fabric were tested by antibacterial and pH tests. Effects of antibacterial treatments on air permeability and absorption period of nonwoven fabrics were also analyzed. According to the results, biopolymers changed the thermal stability of PP nonwoven fabric. Antibacterial performances can be ranked as cinnamaldehyde, geraniol, and phenylethyl alcohol from the best. Besides a slight decrease about liquid absorption performance, all of the treated topsheet fabrics are sufficient for an absorbent hygienic product. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48302.
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    Preparation and Characterization of Poly(lactic acid)-Based Poly(ethylene glycol) and Daphne Essential Oil-Loaded Smart Nanofibers for Thermal Protection
    (Amer Chemical Soc, 2024) GungorErtugral, Tugba; Coskun, Yalcin; Oral, Ayhan; Ulusoy, Seyhan
    Phase change material (PCM) stores latent heat energy, and poly(ethylene glycol) (Mw: 4000) (PEG 4000) is also a solid-liquid PCM. PEG and poly(lactic acid) (PLA) polymers are biodegradable. Essential oils are known as plant extracts with antimicrobial properties. In this study, daphne essential oil (DEO) obtained by the distillation method and PLA/PEG/DEO composite nanofibers were prepared by the electrospinning method with PLA, PEG 4000, and daphne (Laurus nobilis L.) essential oil in certain ratios (100/100/20, 100/120/20, and 100/150/20). DEO showed an antibacterial effect against Staphylococcus aureus and Escherichia coli bacteria. Thermal behaviors of the nanofibers were characterized by differential scanning calorimetry and thermogravimetric analysis. Morphological features were observed by scanning electronic microscopy (SEM), crystal behavior by X-ray diffraction analysis, and molecular structures were examined by Fourier transform infrared spectroscopy. Essential oil composition was determined by GC-MS. The thermal decomposition temperatures of the nanofibers were found between 250 and 276 degrees C, and the latent heat storage energies of nanofibers were 69.06, 86.76, and 96.39 J g(-1) at temperatures 59.0 and 54.37 degrees C. High PCM added fiber was observed as 182 nm diameter with 3.264 mu m diameter spheres. The produced nanofiber matrix has the potential to be used in applications such as medicine, textile, and hot food logistics.
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    Zeolite 4A as a jammer of bacterial communication in Chromobacterium violaceum and Pseudomonas aeruginosa
    (Future Medicine Ltd, 2022) Ulusoy, Seyhan; B Akalin, Ramadan; cevikbas, Halime; Berisha, Avni; Oral, Ayhan; Bosgelmez-Tinaz, Gulgun
    Aim: To investigate the hypothesis that zeolites interfere with quorum-sensing (QS) systems of Chromobacterium violaceum and Pseudomonas aeruginosa by adsorbing N-acyl homoserine lactone (AHL) signal molecules. Methods: QS inhibition by zeolite 4A was investigated using an AHL-based bioreporter assay. The adsorption of the AHLs was evaluated by performing inductively coupled plasma-optical emission spectroscopy and confirmed by Monte Carlo and molecular dynamic simulations. Results: Zeolite 4A reduced the violacein production in C. violaceum by over 90% and the biofilm formation, elastase and pyocyanin production in P. aeruginosa by 87, 68 and 98%, respectively. Conclusion: Zeolite 4A disrupts the QS systems of C. violaceum and P. aeruginosa by means of adsorbing 3-oxo-C6-AHL and 3-oxo-C12-AHL signaling molecules and can be developed as a novel QS jammer to combat P. aeruginosa-related infections.