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Öğe A quantitative genetic examination of non-target-site resistance applied to Avena species(Wiley, 2018) Darmency, H.; Uludag, A.Quantitative genetics tools can be used to assess whether using herbicides at low doses drive selection on standing genetic variation in populations leading to non-target-site resistance (NTSR). These tools are particularly important for estimating the number of genes involved and the potential speed of evolution. A short cut to answering questions about the evolution of NTSR may be to measure heritability. The heritability index (H) provides a measure of the potential to develop NTSR and can be simply calculated from classical dose-response experiments. This measure and the associated experimental designs are discussed with two applied examples on Avena spp. (A.fatua and A.sterilis). In these examples, H values ranged from 0.24 to 0.73, which means that selection for NTSR is highly probable in cases with high H value. We suggest that structuring plants into genetic groups (e.g. families or populations) can contribute to our understanding of the evolutionary potential of populations and plant species to evolve resistance, without increasing experimental cost and time.Öğe Are blood pressure values compatible with medication adherence in hypertensive patients(Wolters Kluwer Medknow Publications, 2016) Uludag, A.; Sahin, E. M.; Agaoglu, H.; Gungor, S.; Ertekin, Y. H.; Tekin, M.Background and Aim: In the management of hypertension (HT), maintaining the medication adherence with treatment is as important as starting treatment. Studies have shown that the majority of patients taking medication do not reach their target values. This study aimed to investigate the relationship between the patient medication adherence and blood pressure (BP) values and reflection to general well-being. Material and Methods: The study included 259 primary HT patients. The patients with BP measurements completed the Medication Adherence Self-Efficacy Scale-Short Form 13 and the World Health Organization-5 (WHO-5) well-being index. A Holter device was attached, and 24 h BP monitoring was completed. Results: The mean points for medication adherence scale was 29.2 10.3 (1u40) and mean WHO-5 points was 13.7 4.6 (4u25) for patients. Clinical mean systolic BP was 140.0 12.6 and diastolic 84.8 9.0 mm Hg, while 24 h mean BP was systolic 119.5 10.6 and diastolic 73.3 8.1 mm Hg. While there was negative correlation between medication adherence scale scores and clinical systolic BP (r = 0.171; P = 0.006), there was no correlation with other BP readings. There was no correlation with the WHO-5 score and clinical readings, though there was a positive correlation between ambulatory mean systolic and diastolic BP (r = 0.141; P = 0.023 and r = 0.123; P = 0.049, respectively). There was positive correlation between the patient's medication adherence scores and the WHO-5 scores (r = 0.141; P = 0.023). Conclusion: When clinicians assess medication adherence of patients, they should benefit from objective BP measurements and scales. Subjective and objective findings are important while making clinical decision.Öğe Impact of Higher Carbon Dioxide Concentrations and Elevated Temperatures on the Growth of Field Bindweed (Convolvulus arvensis L.) in Turkey(Tarbiat Modares Univ, 2024) Karaman, Y.; Tursun, N.; Uludag, A.Field bindweed (Convolvulus arvensis L.) is one of the worst weeds in Turkey as well as worldwide. Climate change, with increasing temperature and concentrations of greenhouse gases and unpredictable extreme weather events, has been among the foremost problems of the world. The effect of climate change on crop husbandry and weeds is to be investigated. The effect of rising temperature and CO2 on different populations of C. arvensis was studied under greenhouse conditions in the Malatya Province of Turkey, in 2019. For this study, the weed seeds were collected from 14 provinces throughout Turkey during 2018. Two temperature regimes (day/night 26/16 degrees C and 29/19 degrees C) and two CO2 levels (400 +/- 50 and 800 +/- 50 ppm) were used. Plant aboveground length, root length, and dry weights of root, aboveground parts, and total plant were not affected by temperature, CO2, and seed source. However, seed source affected root length differently depending on temperature and root length, and root dry weight as affected by CO2 level. In addition, seed source and temperature showed significant effect on measured parameters, while no significant effect was determined for CO2.Öğe PREVALENCE AND MUTATIONS OF ?-THALASSEMIA TRAIT AND ABNORMAL HEMOGLOBINS IN PREMARITAL SCREENING IN CANAKKALE PROVINCE, TURKEY(Macedonian Acad Sciences Arts, 2016) Uludag, A.; Uysal, A.; Uludag, A.; Ertekin, Y. H.; Tekin, M.; Kutuk, B.; Sılan, FatmaThe prevalence of beta-thalassemia (beta-thal) carriers in Turkey varies according to region but in general it is 2.0%. Canakkale is a city in the Aegean region of Turkey but no study about beta-thal frequency in Canakkale has been published to date. In this study, we aimed to investigate the frequency of beta-thal mutations in this province. A total of 4452 couples (8904 individuals) applied for premarital thalassemia scans at the Canakkale State Health Directorate Laboratory between January 2008 and June 2012 and scanning was done with high performance liquid chromatography (HPLC). Of 125 beta-thal carriers seen at the Medical Genetics Clinic, Canakkale Onsekiz Mart University, Canakkale, Turkey, for genetic counseling, 46 participated in the study. The remaining 79 patients could not be reached. The prevalence for beta-thal carriers in Canakkale was identified as 1.4% (125/8904). One couple were both beta-thal carriers. beta-Globin gene analysis of 46 carriers found the total frequency of the three most common mutations was 45.6%. These mutations were found to be HBB: c. 93-21G>A [IVS-I-110 (G>A)], 26.08% (12/46); HBB: c. 17_ 18delCT [codon 5 (-CT)], 10.85% (5/46); HBB: c. 20delA [codon 6 (-A)] 8.69% (4/46). This is the first report on the frequency and mutation profiles of beta-thal for Canakkale. The incidence of beta-thal carriers in Canakkale is below the average for Turkey. The most frequently observed mutation profile and rate of beta-thal in our region is different from the other regions of Turkey.Öğe Review of the current situation for Solanum elaeagnifolium in the Mediterranean Basin(Blackwell Publishing Ltd, 2016) Uludag, A.; Gbehounou, G.; Kashefi, J.; Bouhache, M.; Bon, M.-C.; Bell, C.; Lagopodi, A.L.Silverleaf nightshade (Solanum elaeagnifolium, Cav.) is one of the important invasive plant species in Mediterranean Basin countries. Over the last 60 years, this plant has gone from a few accidental introductions to near monospecific populations in many areas of the Mediterranean Basin (in particular Greece and Morocco). Recent findings from Lebanon show that the invasion is ongoing. Solanum elaeagnifolium has a negative impact on crops, causing up to 75% yield loss, as well as an indirect impact by harbouring plant pests and diseases. Solanum elaeagnifolium is toxic to livestock and has a negative affect on the quality of life for humans. Losses of potential resource or revenue caused by its invasion include: decreased forage quality on grazing lands; decreased cropping land and amenity values of public space; increased water loss; increased water conveyancing costs; and increased forest restoration costs. Available control techniques need to be strengthened to reduce the impact of S. elaeagnifolium and prevent its spread. More attention needs to be devoted to biological control, which could provide regional management of this invasive alien plant. Sustainable management of S. elaeagnifolium will require coordination, education and support across the affected countries. Governments must have the means to detect, manage and control S. elaeagnifolium. © 2016 The Authors.Öğe Status of invasive alien plants included in EPPO Lists in Turkey(2015) Arslan, Z.F.; Uludag, A.; Uremis, I.Turkey is one of the richest areas in the middle latitudes in terms of plant diversity. It has approximately 12 000 plant species and a great number of new species are being added each year. However, invasive alien species have not yet been fully considered in Turkey and only two plant species are in Turkey's quarantine list (Arceuthobium spp. and Eichhornia crassipes). EPPO is an intergovernmental organization responsible for cooperation in plant protection in the European and Mediterranean region and maintains the A1 and A2 Lists of pests recommended for regulation (A1 species are absent from the EPPO region, A2 species are present but of limited distribution), the List of Invasive Alien Plants, the Observation List of invasive alien plants and the Alert List. Eichhornia crassipes, Heracleum persicum, Heracleum sosnowskyi, Ludwigia peploides, Polygonum perfoliatum and Solanum elaeagnifolium are among the species which were recorded in Turkey and are included in the EPPO A2 List. Species recorded in the EPPO List of invasive alien plants which are present in Turkey are: Acroptilon repens, Ailanthus altissima, Ambrosia artemisiifolia (= A. elatior), Carpobrotus edulis, Cortaderia selloana, Cyperus esculentus, Paspalum distichum (= P. paspalodes), Oxalis pes-caprae and Sicyos angulatus. Azolla filiculoides and Rhododendron ponticum are listed in the EPPO Observation List of Invasive alien plants and Miscanthus sinensis, listed in the EPPO Alert List, are also recorded in the Turkish flora. © 2015 OEPP/EPPO.Öğe Stria gravidarum is genetic but not related with collagen gene polymorphism(Gene Therapy and Molecular Biology, 2013) Cakir Gungor, Ayse Nur; Oguz, S.; Uludag, A.; Sılan, Fatma; Gencer, M.; Uysal, A.; Isik, S.Background: Striae Gravidarum (SG) is a common problem that complicates the pregnancies. We aimed to evaluate the possible etiologic factors of SG and the possible importance of collagen polymorphism on SG. Methods: Totally 151 parous women were evaluated for SG and its possible risk factors and their collagen1A1 (coll 1A1) gene polymorphism were investigated. Results: Risk factors that might affect the striae score were evaluated by univariate variant analysis (ANCOVA) and only the maternal striae history seemed to be related with the stria formation. col 1A1 G2046T polymorphism is frequent in the SG group but the difference was not statistically significant (Odds ratio 1.33, %95CI 0.36-4.86, p=0.66). Conclusion: As the best of our knowledge this is the first study that searches for the relationship between col 1A1 polymorphism and SG. We failed to show a relationship between SG and col 1A1 polymorphism. Gene polymorphisms might be various among the different races and ethnic groups. So studies with either the larger sample size or the other races must be done.Öğe Stria Gravidarum Is Genetic But Not Related With Collagen Gene Polymorphism(Gene Therapy Press, 2013) Gungor, Cakir A. N.; Oguz, S.; Uludag, A.; Sılan, Fatma; Gencer, M.; Uysal, A.; Isik, S.BACKGROUND: Striae Gravidarum (SG) is a common problem that complicates the pregnancies. We aimed to evaluate the possible etiologic factors of SG and the possible importance of collagen polymorphism on SG. METHODS: Totally 151 parous women were evaluated for SG and its possible risk factors and their collagen1A1 (coll 1A1) gene polymorphism were investigated. RESULTS: Risk factors that might affect the striae score were evaluated by univariate variant analysis (ANCOVA) and only the maternal striae history seemed to be related with the stria formation. col 1A1 G2046T polymorphism is frequent in the SG group but the difference was not statistically significant (Odds ratio 1.33, % 95CI 0.36-4.86, p= 0.66). CONCLUSION: As the best of our knowledge this is the first study that searches for the relationship between col 1A1 polymorphism and SG. We failed to show a relationship between SG and col 1A1 polymorphism. Gene polymorphisms might be various among the different races and ethnic groups. So studies with either the larger sample size or the other races must be done.
