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    Hematological reference intervals of some snake species in Turkey
    (Tubitak Scientific & Technological Research Council Turkey, 2011) Tosunoğlu, Murat; Gul, Cigdem; Yilmaz, Nilgun; Topyildiz, Huseyin
    In this study, some blood parameters were studied in 7 distinct snake species (Dolichophis caspius, Eirenis modestus, Malpolon monspessulanus, Natrix natrix, Platyceps rubriceps, Telescopus fallax, and Typhlops vermicularis) of the families Colubridae and Typhlopidae, collected from various regions of Turkey. A total of 7 hematologic parameters, namely red blood cell count (RBC), white blood cell count (WBC), hematocrit value (HCT), hemoglobin concentration (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC), were examined. It was detected that Platyceps rubriceps had the highest erythrocyte count and the lowest MCV value among the species examined, Telescopus fallax had the lowest erythrocyte count and hematocrit value, and Eirenis modestus had the highest hematocrit and MCV values. With this study, the variations observed in the blood measurements and counts of snakes were also observed in clinical parameters.
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    Öğe
    Histopathological effects of Montivipera xanthina venom on rats
    (Tubitak Scientific & Technological Research Council Turkey, 2012) Topyildiz, Huseyin; Hayretdag, Sibel
    In this study, the histopathological changes caused by Montivipera xanthina venom to rat skin, skeletal muscle, and liver tissue were analysed by light microscope. The venom (approximately 2.85 mg/kg) was injected intramuscularly into the gastrocnemius muscle of the rats. The animals were dissected 1, 3, and 6 h after the injection time, and tissue samples were taken. Sections 5 pm thick were taken from paraffin blocks of tissue samples, and the sections were stained with haematoxylin and eosin in order to facilitate examination by light microscope. Examinations showed no damage to the epidermis layer of skin. However, damage to the dermis layer, including oedema, haemorrhage, local bleeding, rare inflammatory cells, strong cell infiltration with mixed characteristics, inflammation around the veins, and fat necrosis, was detected. The damage observed in muscular tissue was myonecrosis, mixed character cell infiltration, haemorrhage, and the formation of inclusion on myofibrils. The liver tissue revealed sinusoidal congestion and hepatocellular degeneration.