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    Comparison of Biomarkers in Blood and Urine According to Phenotypes in Chronic Obstructive Pulmonary Disease: Cross-Sectional Research
    (Turkiye Klinikleri, 2022) Hünerel, Oylum; Mutlu, Pınar; Mirici, Nihal Arzu; Çakir, Dilek Ülker; Türkön, Hakan; Gül, Abdulhakim Hasan
    Objective: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. Biomarkers have been recognized as an important tool in assessing COPD patients. In this study, we aimed to investigate the possible relationship between certain biomarkers and different COPD phenotypes. Material and Methods: Between January 1, 2017-December 31, 2017, a total of 85 patients who were admitted to the Çanakkale Onsekiz Mart University Faculty of Medicine Hospital Chest Diseases Outpatient Clinic with a diagnosis of COPD according to the Global Initiative for Chronic Obstructive Lung Disease 2017 Guidelines were included in this study. All patients filled in the COPD Assessment Test and modified Medical Research Council questionnaires. Patients were divided into 4 phenotypes: emphysema, chronic bronchitis, frequent exacerbation, and asthma COPD overlap syndrome (ACOS). Levels of C-reactive protein (CRP), desmosine, fibronectin, eotaxin, and interleukin (IL)-2 were measured and compared between the phenotypes. Results: The mean age was 64.56 years and 92.9% of the study population were males. Of 85 patients, 43 had emphysema, 13 had frequent exacerbation, 15 had chronic bronchitis, and 14 had ACOS phenotype. Blood fibronectin, eotaxin, and urine desmosine levels were significantly lower in patients with ACOS phenotype compared to the other phenotypes. In patients with the frequent exacerbation phenotype, the CRP level was significantly higher than that of the other three phenotypes. The IL-2 levels were similar in all phenotypes. Conclusion: Our study results suggest that these biomarkers may be useful in the differential diagnosis of COPD phenotypes. © 2022 by Türkiye Klinikleri.
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    Öğe
    Comparison of Biomarkers in Blood and Urine According to Phenotypes in Chronic Obstructive Pulmonary Disease: Cross-Sectional Research
    (2022) Hunerel, Oylum; Mutlu, Pınar; Mirici, Nihal Arzu; Çakır, Dilek Ülker; Türkön, Hakan; Gül, Abdülhakim Hasan
    Bjective: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality world- wide. Biomarkers have been recognized as an important tool in assess- ing COPD patients. In this study, we aimed to investigate the possible relationship between certain biomarkers and different COPD pheno- types. Material and Methods: Between January 1, 2017-December 31, 2017, a total of 85 patients who were admitted to the Çanakkale Onsekiz Mart University Faculty of Medicine Hospital Chest Diseases Outpatient Clinic with a diagnosis of COPD according to the Global Initiative for Chronic Obstructive Lung Disease 2017 Guidelines were included in this study. All patients filled in the COPD Assessment Test and modified Medical Research Council questionnaires. Patients were divided into 4 phenotypes: emphysema, chronic bronchitis, frequent exacerbation, and asthma COPD overlap syndrome (ACOS). Levels of C-reactive protein (CRP), desmosine, fibronectin, eotaxin, and inter- leukin (IL)-2 were measured and compared between the phenotypes. Results: The mean age was 64.56 years and 92.9% of the study popu- lation were males. Of 85 patients, 43 had emphysema, 13 had frequent exacerbation, 15 had chronic bronchitis, and 14 had ACOS phenotype. Blood fibronectin, eotaxin, and urine desmosine levels were signifi- cantly lower in patients with ACOS phenotype compared to the other phenotypes. In patients with the frequent exacerbation phenotype, the CRP level was significantly higher than that of the other three pheno- types. The IL-2 levels were similar in all phenotypes.Conclusion: Our study results suggest that these biomarkers may be useful in the differ- ential diagnosis of COPD phenotypes.
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    Glucagon-like peptide-2 May Assist to Protect against Valproic Acid Induced Hepatic Injury in Rats
    (2020) Öztopuz, Özlem; Aylanç, Hakan; Şehitoğlu, M.Hilal; Türkön, Hakan; Battal, Fatih; Demir, Ufuk
    VPA is widely used in epilepsy and other psychological disorders, increasing the probability of developing non-alcoholic liver diseasein long-term treatments. GLP-2 is a proglucagon belonging to the peptide family expressed in the intestine, pancreas and brain to date.Although there are many studies on the use of GLP-2 for therapeutic purposes on the gastrointestinal system, its effect on liver toxicityis unknown. We aimed to investigate the effect of GLP-2 administration on hepatic function in a rat model with VPA-inducedhepatotoxicity. Rats were injected intraperitoneally at 500 mg/kg and GLP-2 5µg/kg a day. The rats (200-250g) were separated into fourgroups (n=7). Group C was administrated 1 mL of 0.9% SF, Group GLP treated with GLP-2 (5µg/kg/day), Group GLP+VPA werereceived GLP-2 (5µg/kg) 1 h prior to VPA (500 mg/kg), Group VPA received VPA (500 mg/kg), 1 h prior to 1 mL of 0.9% SF ip (n=7).Liver tissues were used to investigate effects of VPA and GLP-2 in the liver 15 days after application. While VPA caused moderate butsignificant liver damage according to biochemical results, mRNA expression of cytokines were found to significantly increase after theday 15. VPA administration significantly induced expression of Interleukin 1 beta (IL-1?), Tumor necrosis factor alpha (TNF-?),Interleukin 10 (IL-10). In contrast, GLP-2 treatment reduced expression of IL-1?, TNF-? and IL-10. Also malondialdehyde (MDA),glutathione s-transferase (?-GST), superoxide dismutase activities (SOD), total antioxidant status (TAS) and total oxidant status (TOS)levels were estimated. GLP-2 had positive effects on both liver enzymes and oxidative stress markers in VPA-induced hepatotoxicity.These results suggest that endogenous GLP-2 administration is associated with a mechanism that moderately protects liver tissue.
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    Serum ischemia-modified albumin levels in adolescent smokers
    (Walter de Gruyter GmbH, 2018) Battal, Fatih; Tekin, Mustafa; Aylanç, Hakan; Ylldlrlm, Şule; Türkön, Hakan; Binneto?lu, Fatih Köksal; Kaymaz, Nazan
    It is known that the biochemical marker linked to tissue ischemia, ischemia-modified albumin (IMA), is related to oxidative stress. Cigarette smoking is a situation with increased oxidative stress causing cell damage and it is thought that many of the negative effects linked to smoking may occur after the biological material in the body is exposed to oxidative damage. This study aimed to identify variability in serum IMA levels in adolescents who smoke. This case-control study comprised 60 adolescents without any chronic disease. The smoking group was 30 adolescents between the ages of 14 and 17 years who smoked, while the control group was 30 healthy adolescents who did not smoke. Blood samples were collected from all subjects and serum IMA levels and serum nicotine metabolites were determined. The serum IMA levels in the adolescents who smoked were 0.452±0.094 absorbance unit (ABSU), while the control group had ASBU levels of 0.427±0.054. There was no significant difference between the groups in terms of serum IMA levels (p=0.210). There was a significant difference between the control and smoking groups in terms of serum nicotine metabolite levels (p<0.001). Among adolescents who smoke, serum IMA levels may not be a good marker for oxidative stress. © 2018 Walter de Gruyter GmbH, Berlin/Boston.
  • Küçük Resim
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    Serum spexin, adiponectin and leptin levels in polycystic ovarian syndrome in association with FTO gene polymorphism
    (Via Medica, 2021) Beyazıt, Fatma; Hız, Merve Meliha; Ünsal, Mesut Abdulkerim; Türkön, Hakan
    Objectives: Polycystic Ovary Syndrome (Pcos) Is A Complex Reproductive Endocrinopathy Among Reproductive-Aged Women And Related With Body Mass And Insulin Resistance. Adipocytokines Produced By Adipose Tissue Seems To Take Part In The Hormonal And Metabolic Alterations That Arise In Pcos. Fat Mass And Obesity Associated (Fto) Gene Is Linked With Body Mass Index (Bmi) And Diabetes. Aims — To Investigate The Association Between Fat Mass Related Adipocytokines And Single Nucleotide Polymorphisms (Snps) (Rs9939609 T/A) In The Fto Gene In Women With Pcos. Study Design — Cross-Sectional Study Material And Methods: Fto+Rs9939609 Gene Polymorphism And Serum Spexin, Adiponectin And Leptin Levels Were Deter-Mined In 91 Pcos Women And 86 Healthy Controls. Study Participants Were Subdivided According To Bmi And Comparisons Were Made Within Each Group. Results: Serum Spexin Levels Were Not Differed Between Study Groups. Serum Levels Of Adiponectin Were Found To Be De-Creased In Pcos Women With Bmi Lower Than 25 Kg/M2 (10.1 ± 5.6 Vs 14.1 ± 9.1, P = 0.015). Serum Leptin Levels Were Elevated In Obese Pcos Women Compared To Healthy Control Group (2197.9 ± 596.3 Pg/Ml Vs 1535.9 ± 812.1 Pg/Ml, P = 0.001). The Prevalence Of A Risk Allele Of Snp Rs9939609 Was More Frequent In Pcos Patients Than In The Control Group. Pcos Risk Was Found To Increase 3 Times More In Aa Genotype When Compared With Tt Genotype (Or = 3.04 95% Ci: 1.243–7.309; P = 0.013). Conclusions: Serum Adiponectin And Leptin Levels May Serve As Independent Markers For Pcos Diagnosis. Moreover, The Fto+Rs9939609 Gene Polymorphism Increase Susceptibility To Pcos Development Independent From Serum Adipocytokine Levels
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    The effect of kangaroo care on cortisol levels and immune factors in breast milk
    (NLM (Medline), 2023) Yılmaz Kurt, Fatma; Küçükoğlu, Sibel; Aytekin Özdemir, Aynur; Oğul, Tanju; Türkön, Hakan; Atay, Selma; Aşki, Nesrin
    This paper investigated the effect of kangaroo mother care (KMC) in the early postpartum period on cortisol levels and immune factors in breast milk. This quasi-experimental study was conducted at the obstetrics clinic of a university hospital in western Türkiye. The sample consisted of 63 mothers and their infants. All mothers had a cesarean delivery. Participants were divided into control (n = 32) and experimental groups (n = 31). The control group received routine care at the clinic. The experimental group received KMC for the first 3 days after birth in addition to the routine care at the clinic. Milk samples were collected on the third day after delivery to examine cortisol, IgA, IgM, and IgG levels. All parameters were measured using the enzyme-linked immunosorbent assay method. The experimental group had lower cortisol levels (17.740 ± 1.438) than the control group (18.503 ± 1.449) (p < .05). This result showed that the difference between the two groups was clinically significant (effect size = .53). There was no significant difference in IgA, IgM, and IgG levels between the groups (p > .05). The experimental and control groups had similar immunological factors, but the former had lower cortisol levels than the latter. Therefore, healthcare professionals should encourage mothers to provide KMC to their infants as soon as possible.
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    The Relationship between Cardiac Fatty Acid Binding Protein and Acute Coronary Syndrome Risk Scores
    (2020) Küçük, Uğur; Türkön, Hakan; Altun, Burak
    Objective: Heart type fatty acid binding protein (H-FABP) is a low moleculer weight major cytoplasmic protein and released quickly from cardiomyocytes in response to myocardial injury. We searched functionality of H-FABP in diagnosis of acute coronary syndrome (ACS) and prevalence of coronary artery disease, relationship with its severity and early diagnosis.Materials and Methods: This was a prospective observational study. We took in 110 patients- aged 18 and above-diagnosed ACS between the dates February 2016 and January 2017. The patient population was divided into two groups as ST segment elevation ACS (STEMI, 52 patients) and Non-ST segment elevation ACS (NSTE-ACS, 58 patients). For H-FABP and cardiac troponin I (cTnI) blood samples of the patients were taken both when they first applied to the hospital and six hours later. Coronary angiography was performed to all the patients. Results: On admission, it wasn’t found a statistically significant relationship in both groups, GRACE (Global Registry of Acute Coronary Events), SYNTAX (The synergy between percutaneous coronary intervention with taxus and cardiac surgery) and between Gensini Risk skores (p=0.056, p=0.791, p=0.278). The H-FABP level of blood samples looked over six hours later with GRACE and Gensini risk scores were statistically significant in the H-FABP positive group (p=0.003, p=0.011). However SYNTAX risk score in H-FABP positive group was not statistically significant (p=0.984).Conclusion: In our study, we demonstrated the relationship between H-FABP and coronary artery disease risk scores and that H-FABP can be used in the diagnosis of ACS.