Yazar "Suner, Salih Can" seçeneğine göre listele
Listeleniyor 1 - 7 / 7
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Antibakteriyel poli(laktik asit) hazırlanması(Çanakkale Onsekiz Mart Üniversitesi, 2014) Suner, Salih Can; Oral, AyhanGünümüzde, farklı uygulama alanları için antibakteriyel matriks son derece önemli hale gelmiştir. Bu alanlara, gıda ambalajı uygulamalarında gıdanın raf ömrünün arttırılması, biyomedikal ve tıbbi uygulamalarda bakteri ve mikroorganizma çoğalmasının önlenmesi örnek olarak verilebilir. Bu amaçla farklı polimer matriksler kullanılmaktadır. Bunlardan birisi de Poli(laktik asit)tir (PLA). PLA yenilenebilir kaynaklardan elde edilmesi, diğer polimerlere göre doğada daha hızlı bozunması, biyobozunur ve biyouyumlu olması gibi özellikleri nedeniyle günümüzde, fazlaca kullanılmaya başlanmıştır. Son yıllarda aromatik uçucu yağlara olan ilgi de farklı özelliklleri (antibakteriyel, antioksidan, aromaterapi gibi) artmaktadır. Bu çalışmada PLA filme, aromatik uçucu yağlardan olan Sinamaldehit ve Geraniol kullanarak anti bakteriyel özellik kazandırılmıştır. PLA'e belirli oranlarda eklenen antibakteriyel özellikteki bu maddelerin, Staphylococcus aureus ve Esherichia coli bakterileri üzerinde etkisi disk difüzyon yönteminde oluşan inhibisyon zon çapına göre negatif ve pozitif doğrulama yapılarak araştırılmıştır. % 50 oranında sinamladehit içeren PLA filmin S. aureus ve E. coli için yüksek derecede antibakteriyel özelliği bulunduğu tespit edilmiştir.Öğe Antibiotic loaded electrospun poly (lactic acid) nanofiber mats for drug delivery system(Elsevier, 2022) Suner, Salih Can; Yildirim, Yeliz; Yurt, Fatma; Ozel, Derya; Oral, Ayhan; Ozturk, IsmailActive material-loaded nanofibers becoming more important, because of their applications in many areas such as wound healing, skin engineering, and drug release. This study was conducted to compare the release kinetics of three different antibiotics loaded on nanofibers in Phosphate-buffered saline (PBS) solution and their inhibition properties against bacteria. The three different commercial antibiotics; vancomycin (VAN), ceftriaxone (CFT), and cefpodoxime (CFD) were loaded into Polylactic acid (PLA) nanofibers via electrospinning process with different percentages; 5%, 7.5%, and 10% weight ratios of PLA. The SEM images of PLA/Antibiotic nanofibers and pure PLA nanofiber revealed an increase in diameters with the presence of antibiotics embedded in PLA nanofiber. The TGA analysis showed that the thermal degradation of CFD and VAN-loaded nanofibers were higher than neat PLA, while the thermal stability of CFT loaded nanofibers was the lowest. In the Tan Delta curves, the Tg temperatures of CFD, VAN, CFT loaded nanofibers and pure PLA nanofiber were determined as 54.56 degrees C, 54.57 degrees C, 53.86 degrees C, and 53.55 degrees C, respectively. As can be seen from the results, the variation of the glass transition temperatures supports the DSC data. Drug releasing behaviors of PLA/Antibiotic nanofibers were investigated by Ultraviolet-Visible Spectroscopy at 280, 242 and 230 nm wavelength for VAN, CFT, and CFD antibiotics, respectively. Drug-releasing amounts were gradually increased by increasing the drug loading amounts from 5% to 10%. PLA-VAN, PLA-CFT, and PLA-CFD nanofibers which contain 10% of drugs were delivered about 79%, 75%, and 29% of drugs linearly within nearly 380 h, 500 h, and 360 h, respectively. The formulations including CFT at different concentrations were found to be effective against Staphylococcus aureus and Escherichia coli in a dose-dependent manner. The formulations including CFD and VAN at different concentrations have also inhibited the growth of S. aureus.Öğe Cinnamaldehyde-poly (lactic acid)/gelatin nanofibers exhibiting antibacterial and antibiofilm activity(Taylor & Francis Ltd, 2024) Akpinar, Zeynep; Ulusoy, Seyhan; Akgun, Mert; Oral, Ayhan; Suner, Salih CanBacterial infections and biofilms are known to impede the wound-healing process. Naturally derived compounds from plants hold promise in inhibiting or preventing bacterial biofilms, with cinnamaldehyde (CA) being recognized for its antibacterial and antibiofilm properties. In this investigation, three-dimensional, antibacterial, and biodegradable nanofibers were synthesized via electrospinning, employing FDA-approved polylactic acid (PLA), gelatin (Gel), and the phytoactive molecule cinnamaldehyde (CA). The cinnamaldehyde content, morphology, and physical as well as biological characteristics of the electrospun PLA-Gel-CA nanofibers were scrutinized using HPLC, SEM, TGA, and FTIR analysis. The antibacterial activity of the PLA-Gel-CA nanofibers against Staphylococcus aureus and Pseudomonas aeruginosa, along with their antibiofilm activity against P. aeruginosa, were evaluated. The average diameters of PLA-Gel-CA nanofibers, specifically PLA-Gel-CA1, PLA-Gel-CA2, and PLA-Gel-CA3, were determined to be 294.9 +/- 46.8 nm, 254 +/- 58.3 nm, and 728.5 +/- 98.3 nm, respectively. PLA-Gel-CA3 nanofibers demonstrated notable antibacterial efficacy against S. aureus (31.0 +/- 1.20 mm) and P. aeruginosa (16.0 +/- 1.20 mm), along with a significant inhibition of P. aeruginosa biofilm formation by 72.2%. These findings indicate the potential of cinnamaldehyde-loaded nanofibers for wound application owing to their antibacterial and antibiofilm activity, as well as their rapid dissolution characteristics.Öğe Design of Poly(lactic) acid/gelatin core-shell bicomponent systems as a potential wound dressing material(Elsevier Ltd, 2024) Suner, Salih Can; Oral, Ayhan; Yıldırım, YelizThe electrospun core-shell nanofiber has great many advantages such as different types of solvents that can be used for changing flexibility, mechanical properties, or surface chemistry of fiber. Hydrophobic Poly(lactic) acid (PLA) and hydrophilic gelatin (Gel) were electrospun by various preparation conditions to design perfect bicomponent PLA:Gel nanofiber in a core-shell structure. Solvent types, the concentration of polymeric components, flow rate, and voltage of the electrospinning process were changed to optimization of nanofiber. According to the SEM images, the best nanofiber structure without beads was obtained at 0.4 ml/h flow rate of PLA solution and 1.2 ml/h flow rate of Gel solution at 45:55 (w:w %) weight ratio of PLA:Gel in trifluoroethanol solvent with a 10 kV voltage at 10 cm distance to the collector. From the TEM images, the existence of the core-shell structure had been proved which all prepared nanofibers with 2,2,2-Trifluoroethanol solvent. Furthermore, contact angle measurements showed a change in wettability when the Gel amount was increased. Therefore, the mildest synthesis conditions were determined for bicomponent PLA:Gel core-shell nanofibers as a potential wound dressing and dual drug carrier materials.Öğe First record of straight-needle pteropod Creseis acicula Rang, 1828 bloom in the Canakkale Strait (NE Aegean Sea, Turkey)(De Gruyter Open Ltd, 2021) Tuncer, Sezginer; Öǧretmen, Nazik; Çakır, Fikret; Öztekin, Alkan; Oral, Ayhan; Suner, Salih CanPteropods are marine pelagic calcifier mollusks sensitive to chemical changes in seawater due to their highly soluble aragonite shells. Increased acidity (reduced pH) of seawater causes difficulties in precipitating their shells and/or results in their dissolution, which is related to increased atmospheric CO2 concentrations and warming of seawater. They are therefore indicators of environmental changes. In this paper, we present the first record of the straight-needle pteropod Creseis acicula Rang, 1828 bloom in the surface waters of the Çanakkale Strait, Turkey (NE Aegean Sea), encountered in July 2020, when the highest sea surface temperatures and pH levels since 2007 were recorded. In coastal zones, such as the Çanakkale Strait, anthropogenic activity contributes significantly to environmental changes. Consequently, the increase in pH at elevated temperatures indicates an auxiliary factor (i.e. anthropogenic activity) that triggered the C. acicula bloom, rather than global atmospheric CO2 levels.Öğe Isolation, Chemical Composition, Physicochemical Properties, and Antibacterial Activity of Cupressus sempervirens L. Essential Oil(Taylor and Francis Ltd., 2021) Argui, Hayfa; Youchret-Zalleza, Oumayma Ben; Suner, Salih Can; Periz, Çagdas Deniz; Türker, Gülen; Oral, Ayhan; Coskun, YalçinThis study was carried out to examine some of the biological activities and physicochemical properties of the Cupressus sempervirens L. essential oil (EO). C. sempervirens L. EO was isolated by hydrodistillation. GC-MS was used to identify the compounds of the EO. The results revealed that the major compounds identified in the EO showed a predominance of alpha-pinene (42 %), followed by delta-3-carene (21.26 %) and limonene (5.96 %). The antioxidant activities of the EO were measured with DPPH tests and beta-carotene bleaching. Four bacterial strains, i.e., Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Enterococcus faecalis, were used to assess the antibacterial properties. The C. sempervirens L. EO had remarkable antibacterial activity against S. aureus, E. faecalis and E. coli. It had a contact toxic effect on and manifested a repellent activity against adults of Sitophilus granarius. The latter were optimized at a dose of 0.16 mu l/cm(2).Öğe Preparation of cypress (Cupressus sempervirens L.) essential oil loaded poly(lactic acid) nanofibers(De Gruyter Open Ltd, 2021) Argui, Hayfa; Suner, Salih Can; Periz, Çagdaş Deniz; Türker, Gülen; Oral, Ayhan; Coşkun, Yalçın; Said, HechmiThis study investigated the production of poly(lactic acid) (PLA) nanofibers containing cypress (CUP) essential oil (EO) via electrospinning. The nanofibers were produced from polymer solution prepared with different percentages of cypress EO. Cypress EO-containing PLA nanofibers were characterized and some mechanical and thermal properties were examined using thermogravimetric analysis, scanning electron microscopy, Fourier-transform infrared spectroscopy, and dynamic mechanical analysis. The thermal stability of the nanofibers was reduced depending on the percentage of the cypress EO. As the ratio of the cypress EO to polymer matrices was increased, it was observed that the glassy transition temperatures of the nanofibers decreased and their flexibility increased. The Tg value was determined to be 53.74°C for the neat PLA nanofiber, while 51.83°C for the PLA-CUP nanofiber (containing 15% cypress EO). According to the results of releasing trial, the increased amount of cypress EO resulted in less cypress EO releasing from polymer matrices. The nanofibers were observed to exhibit antibacterial activity against Escherichia coli and Staphylococcus aureus. The inhibition zone diameter of the nanofibers containing 10% cypress EO was 20 mm for S. aureus and 16 mm for E. coli, while 10 mm in the presence of Kanamycin.
