Yazar "Sharopov, Farukh" seçeneğine göre listele

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    A Pharmacological Perspective on Plant?derived Bioactive Molecules for Epilepsy
    (Springer, 2021) Sharifi-Rad, Javad; Quispe, Cristina; Herrera-Bravo, Jesus; Martorell, Miquel; Sharopov, Farukh; Boyuneğmez Tümer, Tuğba; Kurt, Begüm; Lankatillake, Chintha; Docea, Anca Oana; Moreira, Ana Catarina; Dias, Daniel A.; Mahomoodally, Mohamad Fawzi; Lobine, Devina; Cruz-Martins, Natalia; Kumar, Manoj; Calina, Daniela
    Epilepsy is a related chronic neurological condition of a predisposition for recurrent epileptic seizures, with various manifestations and causes. Although there are antiepileptic drugs, complementary natural therapies are widely used. The purpose of this systematic review was to analyze the antiepileptic/anticonvulsant pharmacological properties of plant-food derived bioactive molecules. In this regard, a systematic review of the PubMed database was made based on the inclusion criteria. Natural compounds/herbs with scientifcally proven antiepileptic properties were selected. Experimental pharmacological studies in vitro and in vivo have shown that favonoids, alkaloids and terpenoids may have anticonvulsant mechanisms similar to the new generation antiepileptic drugs. The relationships of structure-anticonvulsant efect, pharmacological models, seizure-inducing factors and response, efective dose were also analyzed and discussed. The results of in vitro and in vivo pharmacological studies analyzed in this systematic review support the clinical importance of plant-food-derived bioactive molecules for the complementary treatment of epilepsy. Thus, are opened new perspectives to develop new natural anticonvulsant drugs.
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    Öğe
    Symphytum Species: A Comprehensive Review on Chemical Composition, Food Applications and Phytopharmacology
    (Mdpi, 2019) Salehi, Bahare; Sharopov, Farukh; Tumer, Tugba Boyunegmez; Ozleyen, Adem; Rodriguez-Perez, Celia; Ezzat, Shahira M.; Azzini, Elena
    Symphytum species belongs to the Boraginaceae family and have been used for centuries for bone breakages, sprains and rheumatism, liver problems, gastritis, ulcers, skin problems, joint pain and contusions, wounds, gout, hematomas and thrombophlebitis. Considering the innumerable potentialities of the Symphytum species and their widespread use in the world, it is extremely important to provide data compiling the available literature to identify the areas of intense research and the main gaps in order to design future studies. The present review aims at summarizing the main data on the therapeutic indications of the Symphytum species based on the current evidence, also emphasizing data on both the efficacy and adverse effects. The present review was carried out by consulting PubMed (Medline), Web of Science, Embase, Scopus, Cochrane Database, Science Direct and Google Scholar (as a search engine) databases to retrieve the most updated articles on this topic. All articles were carefully analyzed by the authors to assess their strengths and weaknesses, and to select the most useful ones for the purpose of review, prioritizing articles published from 1956 to 2018. The pharmacological effects of the Symphytum species are attributed to several chemical compounds, among them allantoin, phenolic compounds, glycopeptides, polysaccharides and some toxic pyrrolizidine alkaloids. Not less important to highlight are the risks associated with its use. In fact, there is increasing consumption of over-the-counter drugs, which when associated with conventional drugs can cause serious and even fatal adverse events. Although clinical trials sustain the folk topical application of Symphytum species in musculoskeletal and blunt injuries, with minor adverse effects, its antimicrobial potency was still poorly investigated. Further studies are needed to assess the antimicrobial spectrum of Symphytum species and to characterize the active molecules both in vitro and in vivo.