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    A hydrazine-bridged dinuclear ruthenium complex: Structural properties and biological activity
    (Elsevier, 2023) Erdener, Digdem; Dervisoglu, Gokhan; Ozdemir, Fethi Ahmet; Serbetci, Zafer; Ozdemir, Namik; Dayan, Osman
    In this study, a new dimeric Ru(II) complex, [Ru(eta(6)-p-cymene)Cl-2](2) (mu(2)-N-2 H-4) (C1), readily synthesized with a reaction of hydrazine hydrate as ligand and [RuCl2(p-cymene)](2) dimmer in dichloromethane. The C1 complex was characterized structurally using IR, NMR, thermal gravimetry and single-crystal X-ray diffraction and theoretically using DFT techniques. Additionally, electrochemical, and optical properties were investigated in cyclic voltammetry and UV-visible spectroscopy. Furthermore, the C1 complex exhibited great antibacterial activity towards 16 Gram + and Gram - species and cell cytotoxicity towards human SH-SY5Y neuroblastoma cell, DU-145 prostate cancer cell, and A549 lung cancer cell lines. (c) 2022 Elsevier B.V. All rights reserved.
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    A neutral arene ruthenium(II) complex with a sulfonated N,O-chelating ligand: Synthesis, characterization, in vitro cytotoxicity and antibacterial activity
    (Pergamon-Elsevier Science Ltd, 2020) Selvi, Gizem; Ozdemir, Fethi Ahmet; Aykutoglu, Gurkan; Ozdemir, Namik; Serbetci, Zafer; Cetinkaya, Bekir; Dayan, Osman
    In this work, a new N,O-type ligand (L1H) containing a sulfonate ester group and its heteroleptic Ru(II) complex (C1) have been prepared and structurally characterized by various techniques, such as UV-vis, ESI-MS, NMR and IR. The spectroscopic results (IR, UV-vis and NMR) were compared with the results of density functional theory (DFT) calculations. The solid-state structures of L1H and C1 were crystallographically verified. Moreover, the in vitro cytotoxicity and antibacterial properties of 1, L1H and Cl have been screened. All the compounds exhibited good cytotoxicity towards human neuroblastoma cancer cells and antibacterial effects towards 16 bacterial strains, both gram positive and negative. The results revealed that the Ru(II) complex exhibits higher biological activities than the starting materials 1 and L1H. (C) 2019 Elsevier Ltd. All rights reserved.
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    Antioxidant Activity of Ruthenium(Ii) Complexes Containing Tridentate Triamines and Their Capability to Inhibit Xanthine Oxidase
    (Springer, 2020) Gecibesler, Ibrahim H.; Dayan, Osman; Serbetci, Zafer; Demirtas, Ibrahim
    Biological activities of organoruthenium complexes [chloro [N,N '-[(2,6-pyridinediyl-kappa N) diethylidyne] bis-[benzenamine-kappa N]] [N-[(2-pyridinyl-kappa N) methylene] benzenesulfonamide-kappa N] ruthenium(II)] chloride (Cmplx 1), [chloro [2,2 '-(2,6-pyridinediyl-kappa N) bis [1H-benzimidazole-kappa N-3]][N-[(2-pyridinyl-kappa N) methylene] benzenesulfonamide-kappa N] ruthenium(II)] chloride (Cmplx 2), and [chloro[2,6-di(1H-pyrazol-3-yl-kappa N-2) pyridine-kappa N] [N-[(2-pyridinyl-kappa N) methylene] [benzenesulfonamide-kappa N] ruthenium(II)] chloride (Cmplx 3) have been studies. The compounds were tested for in vitro biological activity on test models including 2,2-diphenyl-1-picryl-hydrazyl (DPPH) reducing power, superoxide anion radical-scavenging activity, and lipid peroxidation activity by ferric thiocyanate. It is established that Cmplx 2 with benzimidazole ligand displays significant xanthine oxidase inhibitory activity (IC50 = 53.80 +/- 2.69 mu M), DPPH free radical scavenging activity (79.49 +/- 1.59), and superoxide anion radical scavenging activity (75.73 +/- 2.85%). The coordination of benzenamine and benzenesulfanoamine ligands reduces lipid peroxidation as observed in the case of Cmplx 1 (87.17 +/- 3.88%) and the higher reducing power of Cmplx 1 obtained at all concentrations. It was concluded from the test results that organoruthenium complexes showed much better antioxidant activity than expected.
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    Photosensing properties of ruthenium(II) complex-based photodiode
    (Springer Heidelberg, 2019) Imer, Arife Gencer; Dere, Aysegul; Al-Sehemi, Abdullah G.; Dayan, Osman; Serbetci, Zafer; Al-Ghamdi, Ahmed A.; Yakuphanoglu, Fahrettin
    Ru(II) complex containing 2,6-di(1H-pyrazol-3-yl)pyridine ligand was synthesized to prepare organic-based photodiode. After forming the back contact with aluminum metal on p-Si by thermal evaporation, Al/Ru(II) complex/p-Si heterojunction was constructed by inserting Ru(II) complex organic layer into Si substrate. The fundamental electrical parameters and photosensing properties of fabricated heterojunction were investigated by current-voltage and capacitance-voltage measurements under the dark and different light intensities. The studied device exhibits a good rectifying property with rectification ratio of 2.4x10(4) at +/- 7V. It is observed that the photosensing properties such as light sensitivity and photoconductive responsivity of the photodiode based on Ru(II) complex are strongly dependent on the illumination power. The transient measurements show that the heterojunction device has a good photo switching property in the application of the photodiode, photoconductor and photocapacitor. The obtained results declare that the fabricated Ru(II)-based heterojunction device can be used in the organic-based optoelectronic device applications as a photodiode, photosensor, and optical sensor.
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    Superb ruthenium(ii) complex melody: Uncovering its hidden catalytic and biological properties
    (Pergamon-Elsevier Science Ltd, 2024) Duman, Sibel; Dervisoglu, Gokhan; Ozdemir, Fethi Ahmet; Serbetci, Zafer; Erdener, Digdem; Dayan, Osman
    Aliphatic/aromatic nitrogen-substituted ligands have a very important role in ruthenium chemistry. Polydentate ligands with N-substituted pyridine rings are notable for their ability to easily modify the electronic and steric properties of ruthenium. In this study, the catalytic and biological activities of the [RuCl2(NNN)(CH3CN)] (NNN: 2,6-di(1H-pyrazol-3-yl)pyridine)) complex were examined for two different applications. Firstly, the superb Ru(II) complex was used to catalyze the methanolysis of NaBH4, and its initial rate was calculated as 69360 mLH(2)min(-1)g(cat)(-1). Secondly, the biological activities of the superb Ru(II) complex were examined. Accordingly, it was determined that this homogeneous complex showed anti-microbial activity on all bacteria used in the study, among the Gram-positive bacteria used in the study, the best result belongs to the Bacillus cereus EMC 19 bacterium with 8 mm, while among the Gram-negative bacteria, the best zone diameter belongs to the Pseudomonas aeruginosa DSM 50071 bacterium with 5 mm. However, it was observed that zone diameters varied between 8 mm and 3 mm. Compared to the control group, it was determined that 0.25 mg/mL concentration had 94.87%, 0.5 mg/mL concentration 96.10%, 1 mg/mL concentration 96.50%, and 2 mg/mL concentration 97.09% cytotoxic activity on the SH-SY5Y cell line. it was determined that all doses of the superb Ru(II) complex used in the study showed anti-cancer activity, but the anticancer activity shown at low doses was statistically more significant at the p < 0.05 level.
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    Synthesis and catalytic activity of ruthenium(II) complexes containing pyridine-based tridentate triamines ('NNN') and pyridine carboxylate ligands (NO)
    (Elsevier Science Sa, 2012) Dayan, Osman; Ozdemir, Namik; Serbetci, Zafer; Dincer, Muharrem; Cetinkaya, Bekir; Buyukgungor, Orhan
    The reaction of [(p-cymene)RuCl2](2) with K[NOa-b] (NO- = 2-picolinate, a or 2-quinaldinate, b) gave neutral [(p-cymene)RuCl(NOa-b)] (1a-b), complexes which were treated with pyridine-based meridional triamine ligands ('NNN') to create complexes of the type [RuCl(NOa-b)('NNN')] (2a: 'N = N-d, NOa(-) = 2-picolinato; 2b: 'N = N-d, NOb- = 2-quinaldinato; 3a: 'N = N-b, NOa- = 2-picolinato; 3b: 'N = N-b, NOb- = 2-quinaldinato; 4a: 'N = N-p, NOa- = 2-picolinato; 4b: 'N = N-p, NOb- = 2-quinaldinato). The new compounds were characterized by elemental analysis, IR and NMR spectroscopy and, 1b was studied by single crystal X-ray diffraction. The complexes 1-4 have been employed as catalysts for the transfer hydrogenation (TH) of acetophenone derivatives to secondary alcohols in the presence of KOH using 2-propanol as a hydrogen source at 82 degrees C. The highest catalytic activity was obtained with 3a. (C) 2012 Elsevier B. V. All rights reserved.
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    Synthesis and photovoltaic properties of new Ru(II) complexes for dye-sensitized solar cells
    (Springer, 2018) Dayan, Osman; Ozdemir, Namik; Yakuphanoglu, Fahrettin; Serbetci, Zafer; Bilici, Ali; Cetinkaya, Bekir; Tercan, Melek
    Two groups Ru(II) complexes, (1A-C and 2A) (A-C = 2,6-bis(2-benzimidazolyl)pyridines, bbpy, with various substituents at 2-, 5-, and 6-positions) have been prepared and applied for dye-sensitized solar cells (DSSC). The compounds were characterized by various techniques. The optical and electrical properties of sensitizers were investigated with UV-Vis absorption spectroscopy and cyclic voltammetry. High power conversion efficiencies up to 5.16%, have been achieved with 2Ae. Current-voltage characteristics of DSSCs clearly affected by the changing of the ligands at sensitizers. Additionally, computational studies show that locations of frontier molecular orbitals are significantly important for power-conversion efficiencies in DSSCs.
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    Synthesis, DFT computations and antimicrobial activity of a Schiff base derived from 2-hydroxynaphthaldehyde: Remarkable solvent effect
    (Elsevier, 2020) Tercan, Melek; Ozdemir, Namik; Ozdemir, Fethi Ahmet; Serbetci, Zafer; Erdener, Digdem; Cetinkaya, Bekir; Dayan, Osman
    A new Schiff base bearing sulfonamide group was synthesized and characterized by spectroscopic techniques. Its spectroscopic properties were investigated through density functional theory (DFT/B3LYP) method with the 6-311++G(d,p) basis set theoretically and the zwitterion reversible arrow enol tautomerization was studied using IEF-PCM approximation. The thermodynamic (entropy, enthalpy and Gibbs free energy changes) and energetic quantities of the zwitterion reversible arrow enol tautomerization indicate that the migration of single proton between zwitterion reversible arrow enol tautomer's is unfavored for both directions in all phases. During the change from the water phase to the gas phase, the tautomeric energy barrier increases for the proton transfer reaction from the zwitterion form to the enol form, while the barrier decreases from the enol form to the zwitterion form. On the other hand, experimental studies (UV-vis. and NMR spectroscopies) release that there are two tautomeric species which are the zwitterion form in polar and the enol form in apolar solvents for the soluted compound. Furthermore, the antibacterial effect of the compound was investigated in two different solvents (DMSO and THF) to demonstrate the effect of dominant tautomeric species. The results indicate that the solution in which the enol form is dominant than the zwitterionic form has more antimicrobial efficiency for all bacterial species. (C) 2020 Elsevier B.V. All rights reserved.
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    Synthesis, X-ray diffraction method, spectroscopic characterization (FT-IR, 1H and 13C NMR), antimicrobial activity, Hirshfeld surface analysis and DFT computations of novel sulfonamide derivatives
    (Elsevier, 2018) Demircioglu, Zeynep; Ozdemir, Fethi Ahmet; Dayan, Osman; Serbetci, Zafer; Ozdemir, Namik
    Synthesized compounds of N-(2-aminophenyl)benzenesulfonamide 1 and (Z)-N-(2-((2-nitrobenzylidene)amino)phenyl)benzenesulfonamide 2 were characterized by antimicrobial activity, FT-IR, H-1 and C-13 NMR. Two new Schiff base ligands containing aromatic sulfonamide fragment of (Z)-N-(2-((3-nitrobenzylidene)amino)phenyl)benzenesulfonamide 3 and (Z)-N-(2-((4-nitrobenzylidene)amino)phenyl)benzenesulfonamide 4 were synthesized and investigated by spectroscopic techniques including 1H and 13C NMR, FT-IR, single crystal X-ray diffraction, Hirshfeld surface, theoretical method analyses and by antimicrobial activity. The molecular geometry obtained from the X-ray structure determination was optimized Density Functional Theory (DFT/B3LYP) method with the 6-311++G(d,p) basis set in ground state. From the optimized geometry of the molecules of 3 and 4, the geometric parameters, vibrational wavenumbers and chemical shifts were computed. The optimized geometry results, which were well represented the X-ray data, were shown that the chosen of DFT/B3LYP 6-311G++(d,p) was a successful choice. After a successful optimization, frontier molecular orbitals, chemical activity, non-linear optical properties (NLO), molecular electrostatic mep (MEP), Mulliken population method, natural population analysis (NPA) and natural bond orbital analysis (NBO), which cannot be obtained experimentally, were calculated and investigated. (C) 2018 Published by Elsevier B.V.