Yazar "Saritas, Sumeyye" seçeneğine göre listele

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    Comparison of in vitro antioxidant activities of kefir, yogurt, and cheese produced from goat milk
    (Elsevier, 2026) Uzkuc, Hasan; Saritas, Sumeyye; Uzkuc, Nesrin Merve Celebi; Yuceer, Yonca Karagul; Esatbeyoglu, Tuba
    This study compared the physicochemical characteristics and in vitro antioxidant activities of kefir, yogurt, and cheese produced from the same batch of goat milk using specific starter cultures. The physicochemical properties of the samples, as well as the antioxidant capacity (CUPRAC and FRAP) of the in vitro digested samples were analyzed. Additionally, low molecular weight (<3 kDa) peptide fractions were isolated to evaluate their contribution to antioxidant capacity. The highest antioxidant activities (mM Trolox/g protein) based on the CUPRAC assay were observed in yogurt (123.30), followed by kefir (116.05) and cheese (89.35). In contrast, the highest FRAP values were in cheese (22.74), followed by kefir (14.22) and yogurt (14.12). Low molecular weight (<3 kDa) peptide fractions generally showed antioxidant activity similar to or higher than that of the corresponding complete digest samples. Findings highlight the antioxidant potential of fermented goat milk products, especially cheese and kefir, for functional dairy applications.
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    Exploring the Potential of Black Chokeberry (Aronia melanocarpa) as a Health-Enhancing Agent: A Comprehensive Overview
    (Wiley, 2025) Duman, Hatice; Uner, Buket; Saritas, Sumeyye; Bolat, Ecem; Yalcintas, Yalcin Mert; Kalkan, Arda Erkan; Eker, Furkan
    Black chokeberry, scientifically known as Aronia melanocarpa, is native to the eastern part of North America and belongs to the Rosaceae family, specifically falling within the Maloideae subfamily. A sour taste makes fresh chokeberries difficult to eat raw, but they are widely used in the food sector to make wines, fruit teas, juices, jams, jellies, and dietary supplements. Black chokeberries are a rich source of several bioactive compounds. It has been discovered that the fruits of A. melanocarpa exhibit a variety of bioactivities that may be advantageous to human health, such as antioxidant, antiobesity, anti-infective, antidiabetic, and liver- and heart-protective properties. However, to determine the therapeutic capacity, safety, and underlying mechanisms of action of black chokeberries, a comprehensive examination similar to other natural plants and medical items is required. This review provides a comprehensive overview of Aronia plants, covering aspects such as botany, cultivation, bioactive chemical composition, and therapeutic activities to explore their potential health benefits. The findings are expected to significantly influence future research, particularly in the development of functional food products centered around chokeberries.
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    Polyphenols as Antiviral Agents: Their Potential Against a Range of Virus Types
    (Mdpi, 2025) Coskun, Nurten; Demir, Ranya; Canbolat, Ahmet Alperen; Saritas, Sumeyye; Pekdemir, Burcu; Bechelany, Mikhael; Karav, Sercan
    Polyphenols are structurally diverse plant metabolites that have attracted significant interest. Their compositions are versatile, depending on their structures, including the number of rings in the polyphenol composition. Based on these attributes, polyphenols can be classified as flavanols, anthocyanins, flavones, phenolic acids, stilbenes, and lignans. Polyphenols mainly possess inhibition of viral replication, interference with viral protein synthesis, and modulation of immune responses, providing significant antiviral effects against several viruses, including herpes simplex virus, hepatitis C virus, and influenza. They are crucial for medical compounds in diverse, versatile treatments, namely in diabetes, cardiovascular disorders, cancer, and neurodegenerative problems. Plants are the primary source of bioactive molecules, which are valued for their anti-inflammatory, antioxidant, anticancer, and antiviral activities. Especially, polyphenols are extracted as the most abundant bioactive compounds of plants. Moreover, viral infections are one of the major factors in illnesses and diseases, along with bacteria and fungi. Numerous in vitro and in vivo studies report antiviral activity against SARS-CoV-2, Mayaro virus, dengue virus, herpesvirus, and influenza A virus, though clinical validation remains limited. Additionally, inhibition of viral entry, interference with viral replication, modulation of host immune response, and direct virucidal effects were examined.
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    Prebiotic and Functional Fibers from Micro- and Macroalgae: Gut Microbiota Modulation, Health Benefits, and Food Applications
    (Mdpi, 2025) Deniz, Nurdeniz; Saritas, Sumeyye; Bechelany, Mikhael; Karav, Sercan
    Micro- and macro-algae are natural resources that attract attention in terms of their prebiotic potential and functional food applications due to their rich polysaccharide diversity. In this review, the regulatory effects of dietary fibers and polysaccharides from algae on gut microbiota, their health benefits and their potential functions in foods are discussed in detail. Compounds such as fucoidan, laminarin, alginate, porphyran, agar, carrageenan and exopolysaccharides are examined for their interactions with the microbiota and how they support digestive health, immunity and metabolic balance through the production of short chain fatty acids. In contrast to earlier reviews, this paper offers a comprehensive comparison between sulfated and non-sulfated algal polysaccharides, incorporates updated insights on their regulatory status and safety, and highlights emerging direction for developing next-generation prebiotic formulation. The review also examines their applications in functional foods, nutraceutical effects and protective roles, and includes preclinical and clinical studies. However, some limitations such as safety of consumption, risk of heavy metal accumulation, bioavailability issues and regulatory restrictions are also addressed. New nutritional approaches, next generation prebiotic formulations and biotechnological studies are included. This review aims to comprehensively highlight the versatile potential of algal polysaccharides as functional fibers and prebiotics. While numerous studies have examined algal polysaccharides, their heterogeneous structures and safety. This review emphasized these critical gaps and proposed a rational evaluation framework for future research and functional food development.
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    Prebiotics: types, selectivity and utilization by gut microbes
    (Taylor & Francis Ltd, 2025) Yalcintas, Yalcin Mert; Bolino, Matthew J.; Duman, Hatice; Saritas, Sumeyye; Pekdemir, Burcu; Kalkan, Arda Erkan; Canbolat, Ahmet Alperen
    Prebiotics are dietary components selectively utilised by the host's gut microbiota and confer health benefits. They enhance cross-nutritional interactions by supporting beneficial bacteria (particularly Bifidobacterium and Lactobacillus), increase the production of short-chain fatty acids through fermentation, and consequently strengthen the intestinal barrier, balance the immune response, improve metabolic markers (lipid and glucose profiles), regulate key gastrointestinal outcomes such as stool frequency and consistency, and improve some mood/cognitive measures. In early life, human milk oligosaccharides are associated with a Bifidobacterium-dominated ecology and immune development; N-linked and O-linked glycans derived from dietary glycoproteins may exhibit selective utilisation based on binding and species differences; and dietary polyphenols, after limited intestinal absorption, may transform into phenolic metabolites in the colon, shaping the microbiota in a prebiotic-like manner. This review addresses this entire framework, including inulin-type fructans (inulin and fructooligosaccharides), galactooligosaccharides, xylo-oligosaccharides and arabinoxylan-oligosaccharides, isomaltooligosaccharides, lactulose, human milk oligosaccharides, N- and O-linked glycans, and dietary polyphenols as prebiotic-like modulators, with their mechanisms and practical implications.
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    Role of milk glycome in prevention, treatment, and recovery of COVID-19
    (Frontiers Media Sa, 2022) Kaplan, Merve; Sahutoglu, Arif Sercan; Saritas, Sumeyye; Duman, Hatice; Arslan, Aysenur; Pekdemir, Burcu; Karav, Sercan
    Milk contains all essential macro and micro-nutrients for the development of the newborn. Its high therapeutic and antimicrobial content provides an important function for the prevention, treatment, and recovery of certain diseases throughout life. The bioactive components found in milk are mostly decorated with glycans, which provide proper formation and modulate the biological functions of glycosylated compounds. The glycome of milk consists of free glycans, glycolipids, and N- and O- glycosylated proteins. Recent studies have shown that both free glycans and glycan-containing molecules have antiviral characteristics based on different mechanisms such as signaling, microbiome modulation, natural decoy strategy, and immunomodulatory action. In this review, we discuss the recent clinical studies and potential mechanisms of free and conjugated glycans' role in the prevention, treatment, and recovery of COVID-19.
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    The Functional Role of Polyphenols Across the Human Lifespan
    (Mdpi, 2025) Koca, Bekir Enes; Saritas, Sumeyye; Bechelany, Mikhael; Karav, Sercan
    Polyphenols are bioactive molecules that occur naturally in plants and exhibit a diverse array of properties, including antioxidant, anti-inflammatory, and anti-obesity effects, all of which have been supported by numerous studies. They are categorized into four main groups: flavonoids, phenolic acids, stilbenes, and lignans. Polyphenols demonstrate a wide range of health-promoting effects throughout human life, from the womb to old age. They can exert these effects by modulating signaling pathways, regulating gut microbiota, influencing gene expression, and regulating epigenetic pathways. This comprehensive review summarizes the evidence regarding polyphenol intake across various life stages, exploring their effects on immune function, cognitive development, cardiovascular health, and healthy aging. These findings highlight the potential role of polyphenol supplementation in supporting lifelong health. It also emphasizes the significant impact of polyphenols on mental health issues and obesity, which have become more prevalent in modern life. The review also highlights the distinct requirements for each age group, due to changes in metabolic and cellular functions, as well as the age-specific effects of polyphenols. Recent in vitro, in vivo and clinical studies were reviewed to evaluate the biological effects of polyphenols. In the current literature, there are limited studies that directly compare the effects of polyphenols specific to different life stages and comprehensively address the results. This review aims to provide a framework to guide future research by evaluating the effects of polyphenols used in early life, adulthood, and old age.