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    Electroanalytical Investigation of Paracetamol on Glassy Carbon Electrode by Voltammetry
    (Esg, 2015) Engin, C.; Yilmaz, S.; Saglikoglu, G.; Yagmur, S.; Sadikoglu, M.
    An electroanalytical method was developed for the direct quantitative determination of paracetamol (or acetaminophen) in tablet dosage forms based on its oxidation behavior. The electrochemical oxidation and determination of paracetamol were easily carried out on glassy carbon electrode (GCE) using a variety of voltammetric techniques. The electrochemical measurements were carried out on GCE in various buffer solutions in the pH range from 0.51 to 12.00 by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The dependence of pH on the anodic peak current and peak potential was investigated. Acetate buffer (pH 4.51) was selected for analytical purposes. Scan rate studies were also completed. The diffusion controlled nature of the peak was established. A linear calibration curve for DPV analysis was constructed in the paracetamol concentration range from 4x10(-6) mol/L to 1x10(-4) mol/L. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 3.69x10(-7) mol/L and 1.23x10(-6) mol/L respectively. Validation of applied voltammetric techniques was checked with recovery studies.
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    Öğe
    Electroanalytical investigation of paracetamol on glassy carbon electrode by voltammetry
    (Electrochemical Science Group, 2015) Engin, C.; Yilmaz, S.; Saglikoglu, G.; Yagmur, S.; Sadikoglu, M.
    An electroanalytical method was developed for the direct quantitative determination of paracetamol (or acetaminophen) in tablet dosage forms based on its oxidation behavior. The electrochemical oxidation and determination of paracetamol were easily carried out on glassy carbon electrode (GCE) using a variety of voltammetric techniques. The electrochemical measurements were carried out on GCE in various buffer solutions in the pH range from 0.51 to 12.00 by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The dependence of pH on the anodic peak current and peak potential was investigated. Acetate buffer (pH 4.51) was selected for analytical purposes. Scan rate studies were also completed. The diffusion controlled nature of the peak was established. A linear calibration curve for DPV analysis was constructed in the paracetamol concentration range from 4x10-6 mol/L to 1x10-4 mol/L. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 3.69x10-7 mol/L and 1.23x10-6 mol/L respectively. Validation of applied voltammetric techniques was checked with recovery studies. © 2015 The Authors.
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    Öğe
    Electrooxidation of Phenazopyridine Hydrochloride and its Voltammetric and HPLC Determination in Human Urine and Tablet Dosage Form
    (Esg, 2013) Yagmur, S.; Yilmaz, S.; Sadikoglu, M.; Saglikoglu, G.; Yildiz, M.; Yengin, C.; Kilinc, E.
    The electrochemical oxidation of phenazopyridine hydrochloride (PAP) was investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques at ultra trace graphite electrode (UTGE). PAP exhibited a diffusion controlled process which is pH dependence. The dependence of the current and potential on pH, the concentration and nature of buffer, and scan rate was investigated to optimize the experimental conditions for the determination of PAP. It was found that the optimum buffer for the determination of PAP is 0.1 NaOH solutions with the pH 12.97. In the concentration range from 6.0x10(-8) to 1.0x10(-6) M, the current measured by DPV present a good linear property as a function of the concentration of PAP. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 8.1x10(-10) and 2.7x10(-9) M, respectively. PAP was determined in human urine and tablet dosage form. Precision and accuracy of the developed technique were checked by recovery studies in spiked urine and tablet dosage form. In addition, for the comparison, high performance liquid chromatography (HPLC) technique was applied for the determination of PAP in the same samples.
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    The Quantitative Detection of Phenylephrine in Pharmaceutical Preparations and Spiked Human Urine by Voltammetry
    (Pleiades Publishing Inc, 2018) Yagmur, S.; Ture, M.; Saglikoglu, G.; Sadikoglu, M.; Yilmaz, S.
    A voltammetric method was used for the quantitative detection of phenylephrine in pharmaceutical preparations and spiked human urine. The electrochemical measurements were carried out in various buffer solutions in the pH range from 0.51 to 12.00 on ultra-trace graphite electrode (UTGE) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The dependence of pH on the oxidation peak current and peak potential was investigated. Britton-Robinson buffer (pH 8.02) was selected for analytical purposes. The peak was established to be diffusion controlled nature of electrode. A linear calibration curve for DPV analysis was constructed in the phenylephrine concentration range from 8 x 10(-6) to 1 x 10(-4) M. Limits of detection (LOD) and quantification (LOQ) were obtained as 2.07 x 10(-7) M and 6.91 x 10(-6) M respectively. The repeatability, accuracy and precision of the developed technique were checked in spiked urine and pharmaceutical preparations.