Yazar "Quispe, Cristina" seçeneğine göre listele

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    A Pharmacological Perspective on Plant?derived Bioactive Molecules for Epilepsy
    (Springer, 2021) Sharifi-Rad, Javad; Quispe, Cristina; Herrera-Bravo, Jesus; Martorell, Miquel; Sharopov, Farukh; Boyuneğmez Tümer, Tuğba; Kurt, Begüm; Lankatillake, Chintha; Docea, Anca Oana; Moreira, Ana Catarina; Dias, Daniel A.; Mahomoodally, Mohamad Fawzi; Lobine, Devina; Cruz-Martins, Natalia; Kumar, Manoj; Calina, Daniela
    Epilepsy is a related chronic neurological condition of a predisposition for recurrent epileptic seizures, with various manifestations and causes. Although there are antiepileptic drugs, complementary natural therapies are widely used. The purpose of this systematic review was to analyze the antiepileptic/anticonvulsant pharmacological properties of plant-food derived bioactive molecules. In this regard, a systematic review of the PubMed database was made based on the inclusion criteria. Natural compounds/herbs with scientifcally proven antiepileptic properties were selected. Experimental pharmacological studies in vitro and in vivo have shown that favonoids, alkaloids and terpenoids may have anticonvulsant mechanisms similar to the new generation antiepileptic drugs. The relationships of structure-anticonvulsant efect, pharmacological models, seizure-inducing factors and response, efective dose were also analyzed and discussed. The results of in vitro and in vivo pharmacological studies analyzed in this systematic review support the clinical importance of plant-food-derived bioactive molecules for the complementary treatment of epilepsy. Thus, are opened new perspectives to develop new natural anticonvulsant drugs.
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    Bioactive Compounds as Potential Agents for Sexually Transmitted Diseases Management: A Review to Explore Molecular Mechanisms of Action
    (Frontiers Media S.A., 2021) Sharifi-Rad, Javad; Quispe, Cristina; Rahavian, Amirhossein; Pereira Carneiro, Joara Nalyda; Rocha, Janaina Esmeraldo; Alves Borges Leal, Antonio Linkoln; Boyuneğmez Tümer, Tuğba
    Sexually transmitted diseases (STDs) are produced by pathogens like bacteria, fungi, parasites, and viruses, and may generate severe health problems such as cancer, ulcers, and even problems in the newborn. This narrative review aims to present updated information about the use of natural bioactive compounds for the prevention and treatment of sexually transmitted infections. A search of the literature was performed using databases and search engines such as PubMed, Scopus, Google Scholar and Science Direct. From the pharmacotherapeutic management point of view, any strategies for prevention should contain medical approaches. The bioactive compounds obtained from natural products have shown biological effects against different microorganisms for the treatment of these diseases. The main results showed antimicrobial, antiprotozoal, antifungal and antiviral effects such as HIV. Also, the molecular mechanisms, signalling pathways and action targets of natural compounds were highlighted, thus justifying bacterial and antifungal inhibition, apoptosis or reduction of viral replication. From the data of our study, we can conclude that natural compounds may be a significant source for adjuvant drugs / complementary therapies in the treatment of STDs. With all these benefits, the future must conduct extensive clinical trials and the development of pharmaceutical nanotechnologies for a greater therapeutic effect.