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    Behcet disease and pregnancy
    (7847050 Canada Inc, 2014) Gungor, A. N. C.; Kalkan, G.; Oguz, S.; Sen, B.; Ozoguz, P.; Takci, Z.; Sacar, H.
    Purpose: Behcet disease (BD) is a multisystemic vaculitis commonly diagnosed in reproductive years. The authors aimed to investigate the relationship between BD and pregnancy outcomes. Materials and Methods: In this multicenter retrospective survey study, the authors compared the pregnancy outcomes of BD patients with the healthy controls. Results: A total of 298 pregnancies of 94 patients with BD and 219 pregnancies of 95 healthy controls were evaluated. The mean birth weight of all babies of women with BD and the control group were 3,214 grams and 3,351 grams, respectively (p = 0.028). The miscarriage rates were also higher in the BD group. The complication rates of pregnancy with hypertension, preeclampsia, preterm labour in the study group and the control group were 12.8% and 11.6%, respectively (p = 0.489). Conclusion: The current study demonstrated that BD patients delivered smaller babies and they have higher miscarriage rates when compared to the healthy controls which might be due to the vasculitis of the placenta.
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    Öğe
    Stria gravidarum is genetic but not related with collagen gene polymorphism
    (Gene Therapy and Molecular Biology, 2013) Cakir Gungor, Ayse Nur; Oguz, S.; Uludag, A.; Sılan, Fatma; Gencer, M.; Uysal, A.; Isik, S.
    Background: Striae Gravidarum (SG) is a common problem that complicates the pregnancies. We aimed to evaluate the possible etiologic factors of SG and the possible importance of collagen polymorphism on SG. Methods: Totally 151 parous women were evaluated for SG and its possible risk factors and their collagen1A1 (coll 1A1) gene polymorphism were investigated. Results: Risk factors that might affect the striae score were evaluated by univariate variant analysis (ANCOVA) and only the maternal striae history seemed to be related with the stria formation. col 1A1 G2046T polymorphism is frequent in the SG group but the difference was not statistically significant (Odds ratio 1.33, %95CI 0.36-4.86, p=0.66). Conclusion: As the best of our knowledge this is the first study that searches for the relationship between col 1A1 polymorphism and SG. We failed to show a relationship between SG and col 1A1 polymorphism. Gene polymorphisms might be various among the different races and ethnic groups. So studies with either the larger sample size or the other races must be done.
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    Öğe
    Stria Gravidarum Is Genetic But Not Related With Collagen Gene Polymorphism
    (Gene Therapy Press, 2013) Gungor, Cakir A. N.; Oguz, S.; Uludag, A.; Sılan, Fatma; Gencer, M.; Uysal, A.; Isik, S.
    BACKGROUND: Striae Gravidarum (SG) is a common problem that complicates the pregnancies. We aimed to evaluate the possible etiologic factors of SG and the possible importance of collagen polymorphism on SG. METHODS: Totally 151 parous women were evaluated for SG and its possible risk factors and their collagen1A1 (coll 1A1) gene polymorphism were investigated. RESULTS: Risk factors that might affect the striae score were evaluated by univariate variant analysis (ANCOVA) and only the maternal striae history seemed to be related with the stria formation. col 1A1 G2046T polymorphism is frequent in the SG group but the difference was not statistically significant (Odds ratio 1.33, % 95CI 0.36-4.86, p= 0.66). CONCLUSION: As the best of our knowledge this is the first study that searches for the relationship between col 1A1 polymorphism and SG. We failed to show a relationship between SG and col 1A1 polymorphism. Gene polymorphisms might be various among the different races and ethnic groups. So studies with either the larger sample size or the other races must be done.