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Öğe 308G/A and 238G/A polymorphisms in the TNF-? gene may not contribute to the risk of arthritis among Turkish psoriatic patients(Elsevier Science Bv, 2016) Isik, Selda; Sılan, Fatma; Kilic, Sevilay; Hiz, Meliha Merve; Ogretmen, Zerrin; Özdemir, ÖztürkIntroduction: Tumor necrosis factor-alpha (TNF-alpha) is an important proinflammatory cytokine playing a key role in the pathogenesis of psoriasis (Ps) and psoriatic arthritis (PsA). TNF alpha gene promoter region single nucleotide polymorphisms (SNPs) affect the clinical course, severity and the response to the treatment. Aim of the work: To find out whether TNF-alpha-238G/A and -308G/A promoter polymorphism in Ps patients increases arthritis risk. Patients and methods: The study included 129 psoriatic patients (71 with psoriasis only and 58 with PsA). Two single nucleotide polymorphisms in the TNF alpha gene promoter region (238G/A and -308G/A) were genotyped by real-time polymerase chain reaction. Results: Ps patients without arthritis had a mean age of 44.20 +/- 13.85 years (range 18-68 years), while PsA patients had a mean age of 49.15 +/- 13.47 years (range 18-82 years) and presented by dactylitis (67.2%), enthesitis (62.1%) followed by spondylitis (60.3%). Periosteal reaction was present in 19%. The psoriatic arthritis severity index (PASI) was comparable between those with (8.2 +/- 7.1) and without (7.3 +/- 5.12.1) arthritis. The allele positivity of TNF-238A and -308A was not associated with the risk of arthritis among psoriatic patients (OR: 1.002; 95% CI: 0.38-2.6, p=0.99 and OR: 1.27; 95% CI: 0.51-3.2, p=0.6, respectively). In addition, none of the genotypes of the studied TNF-alpha polymorphisms were significantly associated with arthritis. Only spondylitis was significantly associated more frequently with the GG (67.3%) than the GA (22.2%) TNF-alpha-308G/A genotype (p=0.02). Conclusion: None of the haplotypes nor alleles of TNF-alpha-238G/A and -308G/A polymorphisms were significantly associated with arthritis development among psoriatic patients. (C) 2016 Egyptian Society of Rheumatic Diseases. Publishing services provided by Elsevier B.V.Öğe Association between mean platelet volume and disease severity in patients with psoriasis and psoriatic arthritis(Termedia Publishing House Ltd, 2017) Kilic, Sevilay; Resorlu, Hatice; Isik, Selda; Oymak, Sibel; Akbal, Ayla; Hiz, Meliha Merve; Ogretmen, ZerrinIntroduction: Mean platelet volume (MPV) is an important marker that shows the activation and function of the platelets, which is effective in the inflammatory diseases. Aim: To show the relationship between MPV and the development of psoriatic arthritis (PA) in patients with psoriasis vulgaris (PV) and the correlation between MPV and psoriasis severity score (PASI). Material and methods: Our study included 116 patients with psoriatic arthritis (68 female, 48 male) and 41 patients in the psoriasis group (19 female, 22 male) and 90 subjects in the control group (55 female, 35 male). The demographic data of the patients, duration of disease, PAS', the nature of the disease were evaluated retrospectively. Results: Mean platelet volume levels of both the PV group (8.79 +/- 0.86 fl) and the PA group (9.18 +/- 1.26 fl) were significantly higher compared to the control group (8.42 +/- 0.74 fl). There was a weak statistically positive correlation between the PASI and the MPV according to the correlation analysis (r = 0.165; p = 0.046). Conclusions: Our results show that MPV may be helpful as an indicator of the clinical course of PV and PA. In this regard, that study should be supported by prospective studies to find strong correlations.Öğe Association of endothelial nitric oxide synthase Glu298Asp gene polymorphism in psoriasis cases with hypertension(K Faisal Spec Hosp Res Centre, 2014) Ogretmen, Zerrin; Hiz, Meliha Merve; Sılan, Fatma; Uludağ, Ahmet; Özdemir, ÖztürkBACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory skin disease. Although, the molecular mechanism is not completely understood, psoriasis is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of endothelial nitric oxide synthase (eNOS Glu298Asp) gene polymorphism in hypertensive and/or non-hypertensive psoriatic patients (2) to investigate the possible relationship between the eNOS Glu298Asp polymorphism and the risk of hypertension among psoriatic patients in the Turkish population. DESIGN AND SETTINGS: This cross-sectional, case-control study was performed between March 2010 and November 2012 at the University hospital in Canakkale, Turkey PATIENTS AND METHODS: Gene profiles of 75 psoriatic patients (21 hypertensive and 54 normotensive patients) and 55 healthy (normotensive and non-psoriatic) volunteers were compared. Peripheral blood-EDTA samples were used for total genomic DNA isolation and genotyping. Target eNOS gene was genotyped for patients and control groups by real-time PCR melting-curve analysis system (LightCycler 2.0, Roche, Germany, and results were compared statistically. RESULTS: An increased T allele frequency in eNOS Glu298Asp single-nucleotide polymorphism (SNP) was determined in psoriatic patients when compared with normotensive non-psoriatic healthy volunteers (OR 2.3, CI 1.14-3.99), (P=.017). The T allele frequency was also found to be increased in hypertensive psoriatic patients when compared with healthy volunteers (4.83-fold increased, 95% CI 1.62-14.43 ([P=.003]) and normotensive psoriatic patients (3.03-fold increased, 95% CI 1.03-8.94 [P=.041]), respectively. CONCLUSION: The current preliminary results suggested that there was a correlation between eNOS Glu298Asp polymorphism and hypertension among psoriatic patients in the Turkish population. The T allele frequency of eNOS Glu298Asp SNP was different in hypertensive psoriatic patients, and the difference was statistically significant when compared with the normotensive psoriatic patients and healthy controls. These results need to be confirmed by large-scale studies.Öğe Authors reply to Letter to the Editor-In response to: Ersan I, Kilic S, Arikan S, et al. Evaluation of macular ganglion cell-inner plexiform layer and choroid in psoriasis patients using enhanced depth imaging spectral domain optical coherence tomography(Taylor & Francis Inc, 2017) Ersan, Ismail; Kilic, Sevilay; Arikan, Sedat; Kara, Selcuk; Isik, Selda; Gencer, Baran; Ogretmen, Zerrin[Anstract Not Available]Öğe Bullous pemphigoid complicating human orf disease(Pakistan Association of Dermatologists, 2018) Ogretmen, Zerrin; Gül, Ceren; Ekinci, Alper; Akalın, TanerOrf is a zoonosis caused by Parapoxvirus and transmitted to human by sheep. Bullous pemphigoid has been reported as an occasional complication following orf. We report a 51-year-old female who developed bullous pemphigoid 3 weeks following orf. The case is reported for its rare co-occurrence. © 2018 Pakistan Association of Dermatologists. All Rights Reserved.Öğe Clinical features and comorbidities in psoriasis. A retrospective study(Termedia Publishing House Ltd, 2022) Cicekliyurt, Meliha Merve Hiz; Ogretmen, ZerrinIntroduction: Patients with psoriasis may develop several comorbidities. Objective: To determine the clinical characteristics and comorbidities associated with psoriasis. Material and methods: This retrospective case-control study involved 422 adult patients with psoriasis and 444 healthy individuals. The inclusion criteria for patients were: over 18 years old and at least one-year history of confirmed psoriasis. Data, such as age, gender, body mass index, smoking, and alcohol consumption habits were analyzed in addition to detailed physical and dermatological examination. Results: The common comorbidities in patients with psoriasis were depression (n = 144, 34%), hypertension (n = 168, 39.81%), diabetes mellitus (n = 100, 23.7%), coronary artery disease (n = 59, 13.9%) and metabolic syndrome (n = 67, 15.88%). The most common conditions in the control group were hypertension (n = 62, 13.96%), hyperlipidemia (n = 62, 13.96%), diabetes mellitus (n = 42; 9.46%), metabolic syndrome (n = 32; 7.21%) and coronary artery disease (5.41%). Patients with psoriasis are at a higher risk for obesity compared to healthy controls (OR = 1.99; p < 0.0001). In addition, smoking and alcohol consumption were significantly higher in patients with psoriasis (p < 0.0001). Conclusions: These results indicate an increased prevalence of obesity, hyperlipidemia, hypertension, cardiovascular diseases, diabetes, metabolic syndrome, and depression in patients with psoriasis.Öğe Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups(Termedia Publishing House Ltd, 2015) Hiz, Meliha M.; Kilic, Sevilay; Isik, Selda; Ogretmen, Zerrin; Sılan, FatmaIntroduction: STAT4 is an important transcription factor that activates gene transcription as a response to cytokines. Recently, the influence of STAT4 gene on autoimmune disease has been widely studied in many different immune-related diseases. Autoimmune, metabolic and cardiovascular disorders are more common in psoriatic patients. STAT4 may be a unique gene that switches on in autoimmune-related thyroid disease in psoriatic patients. The aim of the study: To explore the association of a STAT4 rs7574865 polymorphism to autoimmune thyroid diseases in the general Turkish population and psoriatic subgroups. Material and methods: A total of 132 psoriatic patients and 118 non-psoriatic volunteers were genotyped for STAT4 rs7574865 using real time PCR. Twenty-four of the psoriatic patients and 15 of the non-psoriatic volunteers have autoimmune-related thyroid diseases. Results: The prevalence of the T allele [OR = 4.37; 95% CI: 1.05-19; p = 0.03] of the STAT4 rs7574865 was higher in individuals with autoimmune-related thyroid diseases among the all non-psoriatic volunteers. The volunteers with autoimmune-related thyroid diseases has an increased allele positivity and carriers having at least one of the risk allele was significantly higher than in counterparts with a GG wild genotype [ORGT/TT vs. GG: 1.73; 95% CI: 0.09-32; p = 0.03]. Yet, there was no evidence of an association between rs7574865 and autoimmune-related thyroid disease in psoriatic patients. Conclusions: The STAT4 rs7574865 polymorphism increases autoimmune-related thyroid disease susceptibility among the general population but not in psoriatic patients.Öğe Evaluation of Macular Ganglion Cell-inner Plexiform Layer and Choroid in Psoriasis Patients Using Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography(Taylor & Francis Inc, 2017) Ersan, Ismail; Kilic, Sevilay; Arikan, Sedat; Kara, Selcuk; Isik, Selda; Gencer, Baran; Ogretmen, ZerrinPurpose: To evaluate changes in the thickness of the central macula, macular ganglion cell-inner plexiform layer (mGCIPL), and subfoveal choroid in patients with psoriasis using spectral domain optical coherence tomography (SD-OCT). Methods: The measurements of macular, mGCIPL thicknesses and subfoveal choroidal thickness (SFCT) obtained by SD-OCT of psoriasis patients (n = 46). These measurements were compared with those of 50 healthy controls. Results: The macular, mGCIPL, and choroidal thicknesses did not differ between the controls and psoriatic subjects (p>0.05). When the patients were divided into two distinct groups, only the SFCT was significantly thicker in the severe psoriasis group compared with the mild psoriasis group (p = 0.003). Conclusions: These findings suggest that choroidal alterations are seen without macular changes in patients with psoriasis. Severe psoriasis appears to be related to increases in SFCT as a consequence of possible inflammatory cascades that are part of the disease's pathogenesis.Öğe Is the HLA B27 genotype a risc faktor for psoriatic arthritis and psoriasis vulgaris?(Deri Zuhrevi Hastaliklar Dernegi, 2014) Ogretmen, Zerrin; Hiz, Merve Meliha; Sılan, Fatma; Kosar, Sule; Özdemir, ÖztürkBackround and Design: Psoriasis is a common inflammatory dermatological disease which may be complicated with joint involvement. It has been suggested that there is an association between HLA-B27 positivity and early onset psoriasis. The purpose of the current study was to investigate the incidence of HLA-B27 positivity in psoriasis patients with arthritis. Materials and Methods: In a total of 96 patients with psoriasis, age of onset, family history, and Psoriasis Area and Severity Index (PAS!) values were recorded. The patients were evaluated with regard to physical examination (presence of arthritis), acute phase reactants, HLA-B27 positivity and joint radiographs. Control group comprised of 100 randomly selected healthy individuals. Results: Thirty (31.250%) patients were with psoriasis alone, 66(68.75%) were with the findings of psoriasis and arthritis. Of the 66 patients, 17 (17.708%) were symptomatic (clinical and radiologic findings) and 49 (51.042%) subjects were asymptomatic (radiologic findings only). Nine patients (6 with psoriasis only and 3 with psoriatic arthritis) and 2 healthy controls were positive for HLA-B27. Conclusion: To carry HLA-B27 antigen increased the risk of psoriasis with an OR of 5.06, and clinically proven psoriatic arthritis with an OR of 10.5 compared to healthy controls. These results need confirmation in a larger group of patients with the inclusion of proper positive and healthy controls.Öğe Is there any increased risk of hypertension, diabetes and cardiac diseases in psoriatic patients with TNF-? G238A and G308A polymorphism?(Termedia Publishing House Ltd, 2016) Isik, Selda; Hiz, Meliha Merve; Kilic, Sevilay; Ogretmen, Zerrin; Sılan, FatmaIntroduction: Psoriasis is regarded as a complex autoimmune disease with strong genetic background. Psoriatic patients suffer from many comorbidities including hypertension, diabetes and cardiovascular diseases. Cytokines such as tumor necrosis factor alpha (TNF-alpha) may be a key player that triggers psoriasis and diabetes, hypertension and cardiac disease at the same time. Aim: To evaluate genetic variations in the TNF-alpha region and its association with psoriasis and related comorbidities. Material and methods: The study covered 129 psoriasis patients with three main subgroups with coronary artery disease (n = 41), hypertension (n = 35), and diabetes (n = 21). DNA samples were genotyped for TNF-alpha G308A and G238A polymorphisms by real-time polymerase chain reaction melting-curve analysis and results were compared statistically. Results: Psoriatic patients with both TNF-alpha-298 and TNF-alpha-308 polymorphisms showed no statistically significant increase in the risk of hypertension (OR = 0.425, chi(2) = 1.76, p = 0.18 and OR = 1.87, chi(2) = 1.33, p = 0.25), coronary artery disease (OR = 1.97, chi(2) = 1.91, p = 0.17 and OR = 2.63, chi(2) = 1.35, p = 0.25), or diabetes (OR = 1.35, chi(2) = 0.24, p= 0.62 and OR = 1.53, chi(2) = 0.24, p = 0.62). Conclusions: The current preliminary results suggested that there was no correlation between TNF-alpha promoter polymorphism and diabetes, hypertension and cardiac disease among psoriatic patients in the Turkish population.Öğe Predicting the Speed of Response to Omalizumab in Chronic Spontaneous Urticaria(Karger, 2024) Keskinkaya, Zeynep; Kaya, Ozge; Mermutlu, Selda Isik; Ogretmen, ZerrinIntroduction: Two distinct chronic spontaneous urticaria (CSU) endotypes, IgE-mediated autoallergic and IgG-mediated autoimmune, were defined based on the response patterns to omalizumab. However, the coexistence of IgE and IgG autoantibodies in a subset of patients might complicate the prediction of the treatment outcomes. This study aimed to evaluate the effectiveness and safety of omalizumab in CSU patients, focusing on the factors predicting the response patterns. Methods: This was a retrospective cross-sectional single-center study investigating CSU patients treated with omalizumab for at least 6 months between September 2015 and February 2023. Patients were evaluated regarding demographics, clinical findings, baseline laboratory parameters, treatment outcomes, and side effects. Early and late responders were defined depending on the time for response, within or after 3 months, respectively. Results: Among 82 patients, 75 (91.5%) responded to omalizumab during the first 6 months, classified as early (n = 51) and late responders (n = 24). The IgG anti-thyroid peroxidase (anti-TPO)/total IgE ratio was an independent predictor for determining the speed of response (p < 0.05). Of 29 patients who discontinued omalizumab, 19 (65.5%) experienced relapse with a good response to retreatment (n = 18/19, 94.7%). Early responders relapsed more frequently than late responders (77.3% vs. 28.6%) (p < 0.05). Only mild side effects were observed in a minority of patients (n = 8/82, 9.8%). Conclusion: Omalizumab is an effective and safe treatment in CSU. The IgG anti-TPO/total IgE ratio seems a valuable tool to predict the early and late responders, the former having a higher possibility of relapse upon drug withdrawal.Öğe Prevalence of skin disorders in primary and secondary school age children in Canakkale, Turkey: a community-based survey(Termedia Publishing House Ltd, 2016) Uludag, Aysegul; Kilic, Sevilay Oguz; Isik, Selda; Ertekin, Yusuf Haydar; Tekin, Murat; Cevizci, Sibel; Ogretmen, ZerrinIntroduction: Skin lesions may be of dermatological importance, affect appearance, and cause problems communicating with peers and may be especially more significant in childhood. Aim: Information on the prevalence of pediatric dermatoses in Western Turkey. This study was aimed to define the existing data. Material and methods: A cross-sectional study was conducted in Canakkale, Turkey, in September-December 2013. It involved 1,957 students from five randomly selected primary and secondary schools. Each student was interviewed for age, gender, and family history, and a dermatologic examination was performed by a dermatologist. Data were coded and analyzed. Results: Of the students, 79.9% revealed at least one dermatosis. The most common disease was benign neoplasms (76%), followed by pigmentary disorders (26.8%), and xerosis (5.8%). In primary schools, the acquired melanocytic nevus, hypopigmented macule, and xerosis; in secondary school the acne was statistically significantly more common. Acne and xerosis was more common in girls, and pityriasis alba was statistically more common in boys. Students who had at least one dermatosis were positively correlated with monthly income. Conclusions: In Turkish school age children, the prevalence of dermatosis is 79.9%. It may be due to not using preventive means for adequate protection from the sun and other environmental factors. Infectious dermatosis and atopic dermatitis are rare and it may depend on the adequacy of public health work.Öğe Primary cutaneous lymphomas: single center experience of dermatology and hematology clinics(Imprimatur Publications, 2014) Payzin, Bahriye; Ogretmen, Zerrin; Yildirim, Aysegul Cidem; Durur, Serap Ozturk; Sentekin, SerraPurpose: To present the clinical characteristics, treatments performed, response to treatment, and follow up of 40 patients diagnosed with primary cutaneous lymphoma. Methods: In this retrospective study included were 23 males and 17 females from our center with confirmed diagnosis of primary cutaneous lymphoma over an 8-year period. Data were retrieved from the patient medical records. Results: The median patient age at diagnosis was 59.5 years (range 33-86). Skin biopsies showed that 31 patients (77.5%) had mycosis fungoides (MF), 2 (5%) had anaplastic large cell lymphoma, 3 (7.5%) had diffuse large B cell lymphoma, 3 (7.5%) had poikilodermic mycosis fungoides, and 1 (2.5%) had non-classified non-Hodgkin lymphoma (NHL). In patients with T cell lymphoma clinical stage IA prevailed (42.5%). The 3 patients with B cell lymphoma had stage IE and 2 of them had B symptoms. Sezary cells were detectable in the peripheral blood of 3 patients. Twenty-three patients (57.5%) used only topical corticosteroids, 2 (5%) were treated with PUVA (psoralen ultraviolet A), 1 (2.5%) was treated with PUVA and chemotherapy, 8(20%) received combination chemotherapy, 1 patient (2.5%) received PUVA+interferon+topical nitrogen mustard, and 1 (2.5%) received chemotherapy+topical nitrogen mustard+interferon. Among 16 patients whith evaluable response to treatment 5 (33%) showed complete remission (CR) and 9 (60%) partial remission (PR). The median follow up time for all patients was 1.5 months (range 1-135). While mean overall survival (OS) time was 123 months (95% Cl 100.6-145.3), the estimated median OS was not reached. Conclusion: Early diagnosis of MF is rather favorable in terms of high and long-term response rates to topical treatments.Öğe Psoriatic Arthritis in Psoriasis Patients: Evaluation of Clinical and Radiological Features(Galenos Yayincilik, 2016) Resorlu, Hatice; Ogretmen, Zerrin; Kilic, Sevilay; Akbal, Ayla; Zateri, Coskun; Cevizci, SibelObjective: The purpose of this study was to perform radiological and clinical determination of the presence of psoriatic arthritis (PsA) in patients with psoriasis and to evaluate associations with clinical findings. Materials and Methods: The medical files of 72 patients with psoriasis presenting to our clinic between years 2009-2014 with a prediagnosis of PsA were reviewed retrospectively. Hand, foot and sacroiliac joint radiograms were evaluated by a radiologist who was blinded to the patient's clinical status and who is experienced on musculoskeletal radiology. Patients with psoriasis were divided into two groups according to the presence of arthritis which was determined based on radiographic findings or on Classification Criteria for Psoriatic Arthritis (CASPAR) criteria. All patients' demographic characteristics, length of disease, nail involvement, smoking-alcohol consumption were recorded. Results: The mean age of all patients was 47.24 +/- 14.61 years, and the mean duration of disease was 14.13 +/- 11.92 years. Smoking and alcohol consumptions were determined in 54.2% (n=39) and 23.6% (n=17) of the cases, respectively. Nail involvement was determined in 56.9% (n=41) of the cases. PsA was determined based on radiological findings in 58.3% (n=42) of the patients. The mean age and age at onset of disease were higher in PsA (+) patients than in radiologically non-PsA subjects. Based on clinical findings, PsA based on CASPAR criteria was determined in only 18.1% (n=13) of all patients. Conclusion: A higher level of PsA was determined using radiological evaluation in this study. The main cause of this condition is the existence of asymptomatic-subclinical patients. A detailed medical history should therefore be taken from patients, and good clinical evaluation is very important. Radiological and clinical evaluation should be performed together in the diagnosis.Öğe Severe candida laryngitis in a patient with rheumatoid arthritis treated with adalimumab(Aves, 2014) Kobak, Senol; Yilmaz, Hatice; Guclu, Oguz; Ogretmen, ZerrinRheumatoid arthritis is a chronic erosive rheumatic disease that can present with polyarticular involvement. Anti-TNF-alpha drugs are used in cases that are resistant to traditional disease-modifying antirheumatic drugs (DMARDs). Anti-TNF-alpha drugs are groundbreaking drugs, the efficacy of which has been proven in the treatment of rheumatoid arthritis. However, the data concerning safety remain limited and contradictory. The risk of tuberculosis reactivation, various infections, as well as lymphoproliferative disease and/ or secondary malignancy is a matter of discussion. In this report, we report a 52-year-old male patient using adalimumab for active rheumatoid arthritis who presented to our polyclinic with generalized mouth and throat sores, hoarseness, and swallowing difficulty. Candida laryngitis was detected in the laryngoscopy and culture samples. Adalimumab was discontinued, and the infection was controlled with anti-fungal treatment.Öğe Skin Prick Test Results of Canakkale Onsekizmart University Faculty of Medicine Dermatology Department(Derman Medical Publ, 2015) Isik, Selda; Ogretmen, Zerrin; Kilic, Sevilay; Cevizci, SibelAim: In this study we aimed to evaluate the prick test results of the patients with chronic urticaria, allergic rhinitis, sinusitis conjunctivitis, pharyngitis, allergic asthma and atopic dermatitis who attended to dermatology department of Canakkale Onsekiz Mart University Faculty of Medicine. Material and Method: The prick test results of 583 patients with chronic urticaria, allergic rhinitis, sinusitis, conjunctivitis, pharyngitis, allergic asthma, atopic dermatitis were assessed retrospectively for this study. 50 standard allergens including pollens, grass, weed, fungal allergens, latex, cat fur, dog hair, house dust mites and foods were performed to the patients. Results: The ages of the patients were between 3 and 70 (mean age was 30.6 +/- 17.5). At least one positive prick test result to any allergen were obtained in 359 patients (61.6%). The most common allergens were; house dust mites (50.5%), weed(28.8%), polen grains(29%), tomato (13.7%), coffee (13.1%), chicken meat (13.0%) and chocolate (12.7%), respectively. Discussion: We think that our study will help to contribute to the allergen map of our country.Öğe The correlation between the psoriasis area severity index and ischemia-modified albumin, mean platelet volume levels in patients with psoriasis(Termedia Publishing House Ltd, 2016) Isik, Selda; Kilic, Sevilay; Ogretmen, Zerrin; Cakir, Dilek Ulker; Turkon, Hakan; Cevizci, Sibel; Hiz, Meliha MerveIntroduction: Ischemia-modified albumin (IMA), a novel ischemia marker, and mean platelet volume (MPV), a determinant of platelet activation, have been reported as elevated markers in cardiovascular risk factors such as atherosclerosis, metabolic syndrome, diabetes mellitus (DM), hypertension, and dyslipidemia. As psoriasis is a chronic inflammatory disease having comorbidities, IMA and MPV can help determine the risk factors for psoriasis. Aim: To investigate the correlation between the psoriasis area severity index (PASO, IMA and MPV levels in patients with psoriasis. Material and methods: This cross-sectional, case-control study was performed between January 2014 and December 2014 at the University hospital in Canakkale, Turkey. Forty-five patients with psoriasis and 44 healthy volunteers over 18 years of age were included in the study. In the psoriasis patient group, clinical features and PASI scores were recorded. Serum IMA and MPV concentrations were evaluated in both groups. Results: The mean IMA values were 0.85 +/- 0.15 and 0.79 +/- 0.09 (in the psoriasis patients and control groups, respectively), and there was a statistically significant difference (p = 0.048). Ischemia-modified albumin levels were not correlated with PASI scores (r = 0.024; p = 0.889) but were correlated with disease duration (r = 0.323; p = 0.048). There was no statistically significant difference between the MPV values of the two groups (8.98 +/- 1.14 and 9.19 +/- 1.28 in the psoriasis patients and control groups, respectively) (p = 0.435). Conclusions: Ischemia-modified albumin may be used as a marker for detecting oxidative stress in patients with psoriasis, especially those with a long disease duration.Öğe The ischemia modified albumin and mean platelet volume levels in patients with Behcet's disease(Termedia Publishing House Ltd, 2016) Kilic, Sevilay; Isik, Selda; Hiz, Meliha Merve; Cakir, Dilek Ulker; Turkon, Hakan; Cevizci, Sibel; Ogretmen, ZerrinIntroduction: Behcet's disease (BD) is a chronic inflammatory disorder with endothelial dysfunction. Ischemia-modified albumin (IMA) is a marker used in the detection of diseases associated with oxidative stress, vascular endothelial cell dysfunction and ischemia. Mean platelet volume (MPV) signifies the platelet function and activity. Aim: To show whether MPV and IMA are useful in revealing the oxidative stress and the risk of thrombosis in patients with BD. Material and methods: Twenty-six patients with BD and 28 healthy volunteers as a control group over 18 years of age were included in the study. Serum IMA and MPV levels were analyzed in both groups. Results: The mean MPV values were identified as 0.86 +/- 0.15 and 0.82 +/- 0.08 (in the BD and control groups, respectively; p = 0.188) and the mean IMA values were 9.39 +/- 0.73 and 9.17 +/- 1.09 (in the BD and control groups, respectively; p = 0.275). There were no statistically significant differences between the groups. The IMA values of BD patients who were in the active phase were significant as compared to inactive BD patients and control groups (p = 0.041). The IMA and MPV values of the thrombotic patients, non-thrombotic patients and control groups were not significant. Conclusions: Ischemia-modified albumin may be a helpful marker of possible complications during an active period of BD.Öğe The successful cure of wide gluteal basocellular epithelioma: A combination therapy of imiquimod cream with cryotherapy(2011) Ogretmen, Zerrin; Uysal, Secil Engin; Onvural, Hacer Köksal[No abstract available]Öğe Triggering drug use in patients with psoriasis: an investigative report from Turkey(Termedia Publishing House Ltd, 2014) Ogretmen, Zerrin; Askin, Ulku; Hiz, Meliha Merve; Cevizci, SibelIntroduction: The patients clinically diagnosed with psoriasis were investigated for drug use that may trigger psoriasis. Aim: To minimize the triggering drug use and help the medical treatment of psoriasis patients. Material and methods: The study involved 289 psoriatic patients who attended our clinic in 2010-2012 and were asked to bring their drug lists of the last year, which they obtained from the pharmacy's record system. They were advised not to use the drugs that may trigger psoriasis. Data analyses were performed using SPSS program version 19.0. Results: A total of 289 patients were included in the study. Two hundred and twenty-one patients were using non-steroidal anti-inflammatory drugs; 133 patients were using anti-reflux drugs; 35 patients were using antidiabetic drugs; 31 patients were using calcium-channel blockers and 24 patients were using beta-blockers. In our study group, there was no significantly difference between median PASI scores of the patients using a triggering drug and those of who are not using a triggering drug. However, there was a positive low correlation between PASI rates and numbers of drugs used (r = 0.180, p = 0.013). Conclusions: Many other factors may trigger psoriasis, therefore the effect of stopping or minimizing the drug use on disease remission is not known. Because of the high triggering drug use rate, it is important to enlighten psoriasis patients about triggering drugs.
