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Electrocatalytic oxidation of moxifloxacin hydrochloride on modified glassy carbon surface and determination in Avelox tablets
(Bulgarian Academy of Sciences, 2019) Sadikoglu, M.; Soylu, U.I.; Yilmaz, S.; Selvi, B.; Yildiz Seckin, H.; Nosal-Wiercinska, A.
This work presents an electroanalytical method for the determination of moxifloxacin hydrochloride (MOX) in tablets. The surface of the glassy carbon electrode (GCE) was modified by electrochemical polymerization of 4-aminobenzene sulfonic acid in phosphate buffer solution (pH 7.0).The oxidative behavior of MOX was studied at glassy carbon and modified glassy carbon electrodes in different buffer systems using the cyclic voltammetry technique. The modified glassy carbon electrode (poly(4-ABSA/GCE) has very high catalytic ability for electrooxidation of MOX. Acetate buffer (pH 5.0) was selected as the optimum medium for the oxidation of MOX at poly(4-ABSA/GCE) due to the highest electronic signal increase obtained. Differential pulse voltammetry (DPV) and chronoamperometry (CA) techniques were used for voltammetric determination of MOX. The values of limit of detection (LOD) and limit of quantification (LOQ) were determined to be 3.19×10 -7 M and 1.06×10 -6 M for DPV; and 5.50×10 -7 M and 1.83×10 -6 M for CA, respectively. A highly sensitive electroanalytical method for the determination of MOX in Avelox tablets by DPV was described. © 2019 Bulgarian Academy of Sciences, Union of Chemists in Bulgaria