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Öğe A polyphenolic biomacromolecule prepared from a flavonoid: Catechin as degradable microparticles(Wiley, 2021) Sağbaş Suner, Selin; Mohapatra, Subhra; Ayyala, Ramesh S.; Brethanabotla, Venkat R.; Şahiner, NurettinCatechin (CAT) was crosslinked with trimethylolpropane triglycidyl ether(TMPTGE) to obtain degradable poly(CAT) particles in a single step. Sphericalp(CAT) particles with tens of micrometer size range and an isoelectronic pointat pH 1.2 were obtained. The hydrolytic degradation of p(CAT) particles pro-vided sustainable and extended release with 264 mg/g CAT release within10 days at pH 7.4. The antioxidant capacity of 55.0 ± 0.9μg/ml gallic acidequivalent in terms of total phenol content, and 0.88 ± 0.3μmol/g trolox equiv-alent were estimated for p(CAT) particles displaying strong radical scavengingcapability. Blood clotting and hemolysis assays demonstrated dose-dependentblood compatibility revealing higher blood compatibility for p(CAT) particlesup to 10μg/ml concentration. The cytotoxicity results show that p(CAT) parti-cles have almost no toxicity for CCD841 normal colon cells at 250μg/ml con-centration in 24 h incubation time giving ~97% cell viability, whereas CATmolecules only provide ~34% cell viabilityÖğe Degradable poly(catechin) nanoparticles as a versatile therapeutic agent(Taylor and Francis Ltd., 2021) Suner, Selin S.; Şahiner, Mehtap; Mohapatra, Subhra; Ayyala, Ramesh S.; Bhethanabotla, Venkat R.; Şahiner, NurettinPoly(catechin) (p(CAT)) nanoparticles (NPs), 173 +/- 4 nm was prepared as a therapeutic agent with hydrolytic degradability affording sustainable CAT release over 20 d at carcinogenic conditions, pH 5.5 and 37.5 degrees C. Cell viability studies on MC38 colon cancer cells revealed the anticancer potential of p(CAT) NPs with 691 mu g/mL IC50 value while being well-tolerated by nonmalignant CCD841 CoN colon cells at 72 h incubation-time. P(CAT) NPs showed effective antioxidant capacity with 241 +/- 7 and 456 +/- 54 mu g/mL of GA equivalency of total phenol content (TPC), and total flavonoid content (TFC) values and 1.19 +/- 0.8 mu mol/g Trolox equivalent antioxidant capacity by 2,2'-Azino-bis-(3-ethylbenzothioazoline-6-sulfonic acid (ABTS(center dot+)) scavenging assay.