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Öğe A Case of Posterior Mediastinal Ganglioneuroma: The Importance of Preoperative Multiplanar Radiological Imaging(Galenos Publ House, 2013) Kizildag, Betul; Alar, Timucin; Karatag, Ozan; Kosar, Sule; Akman, Tarik; Cosar, MuratGanglioneuromas are mostly seen in adolescents and young adults and they are neurogenic tumors originating from sympathetic ganglions with a benign histology. Although ganglioneuromas are benign, the treatment is surgical as they can cause pain or compression symptoms, can be locally aggressive and can lead to cord compression. We present a young adult female with a ganglioneuroma of the right posterior mediastinum who presented with lower back pain, together with the clinical features, Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) findings, differential diagnosis tips and their contribution to surgical planning.Öğe A Wandering Intravascular Scalpel Fragment After Lumbar Discectomy: A Case Report(Turkish Neurosurgical Soc, 2014) Aras, Adem Bozkurt; Ozkan, Omer Faruk; Alar, Timucin; Ozkan, Adile; Arik, M. Kasim; Kosar, Sule; Kirilmaz, BahadirVascular complications after lumbar discectomy are rarely seen. We present a unique and potentially life-threatening postoperative complication from this procedure. A 27-year-old man was admitted to our emergency vascular unit 1 day after a lumbar discectomy, during which a scalpel blade fragmented and a part was lost. Radiological images of the patient were performed and a broken scalpel blade was located anterior to the sacrum. An anterior laparotomy was performed which identified a mass within the left iliac vein that migrated suddenly to the inferior vena cava. An emergency angiography was performed, by which time the scalpel blade had ascended to the right-sided inferior pulmonary artery. It was subsequently removed via a right lateral thoracotomy.Öğe An uncommon cause of multiple pulmonary nodules; hereditary hemorrhagic telangiectasia(Turkish Assoc Tuberculosis & Thorax, 2016) Kosar, Sule; Kizildag, Betul; Canan, Arzu; Karatag, Ozan; Gonlugur, Ugur; Sariyildirim, AbdullahHereditary hemorrhagic telangiectasia ( HHT), or Rendu-Osler-Weber syndrome ( ROWS) is a very rare hereditary disease. The diagnosis is based on the clinical findings such as recurrent epistaxis, telangiectases, visceral arteriovenous malformations (AVMs) and family history. AVMs are found in the liver, lung or brain and could mimick the masses of these organs. Radiologic evaluation plays a critical role during diagnostic and therapeutic management of ROWS. Hence, radiologists should be aware of the diagnosis of HHT in the patients with AVMs, history of epistaxis and family history. We report a patient with multiple pulmonary AVMs secondary to HHT who has referred to our interventional radiology department for computed tomography guided transthorasic lung biopsy procedure with suspicious of malignancy.Öğe Association Between Inherited Thrombophilia and Impaired Right Ventricular Function in Deep Vein Thrombosis Without Symptomatic Pulmonary Embolism(Sage Publications Inc, 2014) Asgun, Halil Fatih; Kirilmaz, Bahadir; Saygi, Serkan; Ozturk, Okan; Sılan, Fatma; Karatag, Ozan; Kosar, SuleThe aim was to evaluate the right ventricular function in patients with inherited thrombophilia and deep vein thrombosis (DVT) without pulmonary embolism. A total of 38 patients with DVT without symptomatic pulmonary embolism and 30 patients with varicose veins were enrolled. Clinical data, echocardiography, and 2 thrombophilic mutations were analyzed. Factor V Leiden (FVL) polymorphism was significantly frequent in the study group (P = .007). The difference in prothrombin G20210A polymorphism between the study and control groups was at a near-significant level (P = .058). There was statistically significant decrease in tricuspid annular plane systolic excursion values in patients with FVL and prothrombin G20210A polymorphism. Combined FVL and prothrombin G20210A polymorphisms were more closely related to the decrease in this value (P = .006). Deep vein thrombosis had no additional adverse effects on right ventricle. Impaired right ventricular systolic function occurs in FVL and prothrombin G20210A polymorphisms.Öğe Atypical spinal tuberculosis: posterior paravertebral spread(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2016) Komurcu, Erkam; Kizildag, Betul; Kosar, Sule; Akman, TarikSpinal tuberculosis phenomenon that is an extra pulmonary form of tuberculosis infection, the prognosis of which changes dramatically by early diagnosis and treatment, is still a significant health problem. While early diagnosis and treatment of typical spinal tuberculosis progressing typically is performed without any problems, incorrect treatment of spinal tuberculosis cases presenting atypical findings can lead to dramatic results despite the improvement in modern imaging techniques. In our study we aimed to present an atypical spinal tuberculosis case, for which a correct diagnosis based on abscess and fistula on the thigh that is unique in literature with accompanying pseudomonas co-infection presenting as an undefined atypical spread.Öğe Concurrent demyelinizing central nervous system involvement in a case of Familial Mediterranean Fever with the M694V mutation(Yuzuncu Yil Universitesi Tip Fakultesi, 2014) Ozkan, Adile; Kosar, Sule; Uludağ, Ahmet; Haznedaroglu, Mete; Karaman, Handan Isın OzısıkFamilial Mediterranean Fever (FMF) is a hereditary disease seen mainly around the Mediterranean. The most common mutations are M694V, M680I, V726A and E148. Neurological findings and magnetic resonance imaging (MRI) abnormalities resembling multiple sclerosis have been reported in a few cases. We present a case where an M694V mutation was found together with familial Mediterranean fever and multiple sclerosis-type demyelinizing disease as this combination is rarely seen. © 2014, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Öğe Epidural Abscess Due to a Mycobacterium tuberculosis Strain with Primary Resistance to Isoniazid and Ethambutol(Ankara Microbiology Soc, 2012) Sener, Alper; Alper Akçalı; Karatag, Ozan; Kosar, Sule; Degirmenci, Yildiz; Akman, TarikTuberculosis is primarily characterized by pulmonary involvement, however, one third of the cases exhibit extrapulmonary tuberculosis. In this report, a case of epidural abscess due to Mycobacterium tuberculosis with primary resistance to isoniazid and ethambutol was presented. A 57-year-old male patient was admitted to emergency service with ten days history of weakness in legs, disability of walking and fever. Neurological examination revealed paraplegia of lower extremities, numbness distal to T2 disc level and hyperactivity of deep tendon reflexes indicating transverse myelitis. Laboratory findings were as follows; ESR: 74 mm/hour, CRP: 22 g/L, ALT: 42 IU/L, AST: 45 IU/L and white blood cell count 23.000/mm(3) (45% polymorphonuclear leukocyte, 45% lymphocyte, 10% monocyte). Spinal magnetic resonance imaging showed a fusiform abscess localized at anterior epidural space and extending along levels of C5-6 and C6-7. The longitudinal dimension of the abscess was 3 cm. The lesion was hypoin-tense on T1 and hyperintense on T2 weighted MRI images with prominent rim shaped contrast enhancement on contrast-enhanced T1-weighted images. At fourth day of hospitalization the patient underwent neurosurgical management. M.tuberculosis was isolated from the cultures of operation material by Mycobacteria Growth Incubator Tube system (MGIT, BBL; BD, USA) on the 12th day. The isolate was found susceptible to streptomycin and rifampisin, but resistant to isoniazid and ethambutol. The treatment was initiated with rifampicin 600 mg/day, pyrazinamid 2 g/day, ethambutol 1.5 g/day and levofloxacin 500 mg/day. At the end of second month levofloxacin 500 mg/day and rifampisin 600 mg/day combination was sustained and total treatment period was planned as nine months. As far as the national literature was considered, this was the first case of extrapulmonary tuberculosis with primary resistance to isoniazid and ethambutol.Öğe Glenohumeral joint tuberculosis with multiple cold abscesses: An uncommon cause of shoulder pain(2013) Kizildag, Betul; Sener, Alper; Komurcu, Erkam; Karatag, Ozan; Kosar, SuleThe musculoskeletal system involvement of tuberculosis (TB) other than spinal TB is a rare and less-known entity. Furthermore symptoms of musculoskeletal involvement of TB infection are non-spesific, relatively slow and indolent. The diagnosis of TB is less considered by clinicians among other common causes of shoulder pain including traumatic and degenerative conditions. We reported a 72-year-old patient suffering shoulder pain for the last 2 years who was diagnosed with glenohumeral joint TB arthrithis associated with multiple cold abscesses in adjacent soft tissues; emphasising significant clinical and imaging findings.Öğe Is the HLA B27 genotype a risc faktor for psoriatic arthritis and psoriasis vulgaris?(Deri Zuhrevi Hastaliklar Dernegi, 2014) Ogretmen, Zerrin; Hiz, Merve Meliha; Sılan, Fatma; Kosar, Sule; Özdemir, ÖztürkBackround and Design: Psoriasis is a common inflammatory dermatological disease which may be complicated with joint involvement. It has been suggested that there is an association between HLA-B27 positivity and early onset psoriasis. The purpose of the current study was to investigate the incidence of HLA-B27 positivity in psoriasis patients with arthritis. Materials and Methods: In a total of 96 patients with psoriasis, age of onset, family history, and Psoriasis Area and Severity Index (PAS!) values were recorded. The patients were evaluated with regard to physical examination (presence of arthritis), acute phase reactants, HLA-B27 positivity and joint radiographs. Control group comprised of 100 randomly selected healthy individuals. Results: Thirty (31.250%) patients were with psoriasis alone, 66(68.75%) were with the findings of psoriasis and arthritis. Of the 66 patients, 17 (17.708%) were symptomatic (clinical and radiologic findings) and 49 (51.042%) subjects were asymptomatic (radiologic findings only). Nine patients (6 with psoriasis only and 3 with psoriatic arthritis) and 2 healthy controls were positive for HLA-B27. Conclusion: To carry HLA-B27 antigen increased the risk of psoriasis with an OR of 5.06, and clinically proven psoriatic arthritis with an OR of 10.5 compared to healthy controls. These results need confirmation in a larger group of patients with the inclusion of proper positive and healthy controls.Öğe Is there an advantage of three dimensional computed tomography scanning over plain abdominal radiograph in the detection of retained needles in the abdomen?(Elsevier Science Bv, 2013) Hacivelioglu, Servet; Karatag, Ozan; Gungor, Aysenur Cakir; Gencer, Meryem; Kosar, Sule; Kizildag, Betul; Yildiz, Yavuz[Anstract Not Available]Öğe Parotid Abscess with Involvement of Facial Nerve Branches(Coll Physicians & Surgeons Pakistan, 2015) Ozkan, Adile; Ors, Ceyda Hayretdag; Kosar, Sule; Karaman, Handan Isin OzisikFacial nerve paresis is only rarely seen with benign diseases of the parotid gland. A 22-year male had muscle loss in the preauricular region of the right side of his face that extended towards the mandibular angle for the last 6 months. The neurological examination did not reveal any pathology other than right preauricular region muscle atrophy that was limited by the mandibular angle. The Electroneuronography (EnoG) provided a ratio of 55.38%, compared the affected side to left side. Ultrasonography of the defined region showed two mass lesions 13.5 x 7 mm and 10 x 5 mm in size in the anteromedial section of the right parotid gland that were close to each other, without internal calcific foci, and heterogenous hyperechogenic structure without internal vascularization. Fine needle aspiration obtained many polymorphonuclear leukocytes, cell debris, a few mononuclear inflammatory cells and many crystalloid structures: The lesion was diagnosed as a parotid abscess. Antibiotic treatment was started for the parotid gland abscess.Öğe Parotid abscess with involvement of facial nerve branches(College of Physicians and Surgeons Pakistan, 2015) Ozkan, Adile; Ors, Ceyda Hayretdag; Kosar, Sule; Karaman, Handan Isin OzisikFacial nerve paresis is only rarely seen with benign diseases of the parotid gland. A 22-year male had muscle loss in the preauricular region of the right side of his face that extended towards the mandibular angle for the last 6 months. The neurological examination did not reveal any pathology other than right preauricular region muscle atrophy that was limited by the mandibular angle. The Electroneuronography (EnoG) provided a ratio of 55.38%, compared the affected side to left side. Ultrasonography of the defined region showed two mass lesions 13.5 x 7 mm and 10 x 5 mm in size in the anteromedial section of the right parotid gland that were close to each other, without internal calcific foci, and heterogenous hyperechogenic structure without internal vascularization. Fine needle aspiration obtained many polymorphonuclear leukocytes, cell debris, a few mononuclear inflammatory cells and many crystalloid structures. The lesion was diagnosed as a parotid abscess. Antibiotic treatment was started for the parotid gland abscess.Öğe Silent Petrous Apicitis(Mediterranean Soc Otology & Audiology, 2012) Guclu, Oguz; Karatag, Ozan; Tufan, Hasan Ali; Kosar, Sule; Derekoy, Fevzi SefaGradenigo syndrome is a quite rare complication of otitis media. Typical presentation of this syndrome includes sixth cranial nerve paralysis/paresis, acute or chronic otitis media, and trigeminal neuralgia. In this study, we report on a six-year-old child with incomplete Gradenigo syndrome consisting of petrous apicitis and abducent nerve paralysis without otitis media symptoms and trigeminal neuralgia.Öğe Single-nucleotide polymorphism in Turkish patients with adolescent idiopathic scoliosis: Curve progression is not related with MATN-1, LCT C/T-13910, and VDR BsmI(Wiley, 2012) Yilmaz, Hurriyet; Zateri, Coskun; Uludağ, Ahmet; Bakar, Coskun; Kosar, Sule; Özdemir, ÖztürkThe role of genetics in the etiopathogenesis of adolescent idiopathic scoliosis (AIS) is unclear. In this study, we investigated the relationship between AIS and polymorphisms in MATN-1, LCT C/T-13910, and VDR BsmI genes. 53 Turkish adolescents with diagnosed AIS and 54 healthy adult individuals were included in the study. MATN-1, LCT C/T-13910, and VDR BsmI gene mutations were analyzed with real-time PCR. We did not detect a statistically significant difference between AIS and control groups in respect to those three different gene polymorphisms (p?Öğe Solitary pancreatic metastases of small cell lung cancer(Elsevier Taiwan, 2013) Gonlugur, Ugur; Mirici, Arzu; Karatag, Ozan; Kosar, Sule[Anstract Not Available]Öğe Tegmen height: preoperative value of CT on preventing dural complications in chronic otitis media surgery(Elsevier Science Inc, 2014) Karatag, Ozan; Guclu, Oguz; Kosar, Sule; Derekoy, Fevzi SefaObjective: The objective was to examine tegmen height in patients with iatrogenic dural exposure in chronic otitis media (COM) surgery. Methods: Computed tomographic (CT) scans of 50 patients who underwent COM surgery were retrospectively examined. Twelve patients with dural exposure were admitted to the dura group. The control group of 38 patients had no dural exposure. Tegmen heights in both groups were compared. Results: There was no statistically significant difference between opposite ears (P>.05). Significant difference was found in tegmen height between healthy and operated ears in unilateral COM patients (P=.001). Conclusion: Preoperative CT assessment of tegmen height is an important parameter in assessing risk of exposing dura during surgery. (C) 2014 Elsevier Inc. All rights reserved.