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Öğe 308G/A and 238G/A polymorphisms in the TNF-? gene may not contribute to the risk of arthritis among Turkish psoriatic patients(Elsevier Science Bv, 2016) Isik, Selda; Sılan, Fatma; Kilic, Sevilay; Hiz, Meliha Merve; Ogretmen, Zerrin; Özdemir, ÖztürkIntroduction: Tumor necrosis factor-alpha (TNF-alpha) is an important proinflammatory cytokine playing a key role in the pathogenesis of psoriasis (Ps) and psoriatic arthritis (PsA). TNF alpha gene promoter region single nucleotide polymorphisms (SNPs) affect the clinical course, severity and the response to the treatment. Aim of the work: To find out whether TNF-alpha-238G/A and -308G/A promoter polymorphism in Ps patients increases arthritis risk. Patients and methods: The study included 129 psoriatic patients (71 with psoriasis only and 58 with PsA). Two single nucleotide polymorphisms in the TNF alpha gene promoter region (238G/A and -308G/A) were genotyped by real-time polymerase chain reaction. Results: Ps patients without arthritis had a mean age of 44.20 +/- 13.85 years (range 18-68 years), while PsA patients had a mean age of 49.15 +/- 13.47 years (range 18-82 years) and presented by dactylitis (67.2%), enthesitis (62.1%) followed by spondylitis (60.3%). Periosteal reaction was present in 19%. The psoriatic arthritis severity index (PASI) was comparable between those with (8.2 +/- 7.1) and without (7.3 +/- 5.12.1) arthritis. The allele positivity of TNF-238A and -308A was not associated with the risk of arthritis among psoriatic patients (OR: 1.002; 95% CI: 0.38-2.6, p=0.99 and OR: 1.27; 95% CI: 0.51-3.2, p=0.6, respectively). In addition, none of the genotypes of the studied TNF-alpha polymorphisms were significantly associated with arthritis. Only spondylitis was significantly associated more frequently with the GG (67.3%) than the GA (22.2%) TNF-alpha-308G/A genotype (p=0.02). Conclusion: None of the haplotypes nor alleles of TNF-alpha-238G/A and -308G/A polymorphisms were significantly associated with arthritis development among psoriatic patients. (C) 2016 Egyptian Society of Rheumatic Diseases. Publishing services provided by Elsevier B.V.Öğe Assessment of ADAM17 and ADAM10 proteins with CXCL10 and thyroid autoimmunity in vitiligo pathogenesis(Termedia Publishing House Ltd, 2022) Kilic, Sevilay; Sehitoglu, Hilal; Gul, CerenIntroduction: Vitiligo is an acquired chronic pigmentation disorder. The etiopathogenesis is still not fully understood. Aim: To research the correlation of ADAM proteins, shown to be associated with autoimmune diseases like rheumatoid arthritis and lupus erythematosus, with vitiligo also considered to be an autoimmune disease. Material and methods: The study included a patient group of 45 patients with the diagnosis of vitiligo and a control group of 45 healthy adults. The ADAM10 and ADAM17 protein serum levels and CXCL10 and thyroid autoantibody anti-TG and anti-TPO levels along with FT3, FT4, and TSH hormone levels were determined with the ELISA method. Statistical analysis of results was made with the SPSS 22.0 program. Results: In vitiligo patients, the ADAM10 levels (2.34 +/- 0.80 pg/ml) were statistically significantly low compared to the control group (10.29 +/- 1.71 pg/ml) (p < 0.05), while the ADAM17 levels (128.51 +/- 14.37 pg/ml) were statistically significantly high compared to the control group (16.30 +/- 6.31 pg/ml) (p < 0.05). Additionally, the CXCL10 levels were observed to be statistically significantly higher in the patient group (275.11 +/- 62.36) than in the control group (107.08 +/- 33.12). Thyroid autoimmunity test results (anti-TG, anti-TPO, and TSH) were shown to be different to a statistically significant degree in the patient group compared to the control group (p < 0.001, p < 0.000, p = 0.003, respectively). Statistical analyses used the Kolmogorov-Smirnov, Mann-Whitney U test, and the independent T-test. Conclusions: We obtained data that are important in terms of understanding the pathogenesis. ADAM10 and ADAM17 proteins may be new targets for future therapeutic approaches.Öğe Association between mean platelet volume and disease severity in patients with psoriasis and psoriatic arthritis(Termedia Publishing House Ltd, 2017) Kilic, Sevilay; Resorlu, Hatice; Isik, Selda; Oymak, Sibel; Akbal, Ayla; Hiz, Meliha Merve; Ogretmen, ZerrinIntroduction: Mean platelet volume (MPV) is an important marker that shows the activation and function of the platelets, which is effective in the inflammatory diseases. Aim: To show the relationship between MPV and the development of psoriatic arthritis (PA) in patients with psoriasis vulgaris (PV) and the correlation between MPV and psoriasis severity score (PASI). Material and methods: Our study included 116 patients with psoriatic arthritis (68 female, 48 male) and 41 patients in the psoriasis group (19 female, 22 male) and 90 subjects in the control group (55 female, 35 male). The demographic data of the patients, duration of disease, PAS', the nature of the disease were evaluated retrospectively. Results: Mean platelet volume levels of both the PV group (8.79 +/- 0.86 fl) and the PA group (9.18 +/- 1.26 fl) were significantly higher compared to the control group (8.42 +/- 0.74 fl). There was a weak statistically positive correlation between the PASI and the MPV according to the correlation analysis (r = 0.165; p = 0.046). Conclusions: Our results show that MPV may be helpful as an indicator of the clinical course of PV and PA. In this regard, that study should be supported by prospective studies to find strong correlations.Öğe Authors reply to Letter to the Editor-In response to: Ersan I, Kilic S, Arikan S, et al. Evaluation of macular ganglion cell-inner plexiform layer and choroid in psoriasis patients using enhanced depth imaging spectral domain optical coherence tomography(Taylor & Francis Inc, 2017) Ersan, Ismail; Kilic, Sevilay; Arikan, Sedat; Kara, Selcuk; Isik, Selda; Gencer, Baran; Ogretmen, Zerrin[Anstract Not Available]Öğe Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups(Termedia Publishing House Ltd, 2015) Hiz, Meliha M.; Kilic, Sevilay; Isik, Selda; Ogretmen, Zerrin; Sılan, FatmaIntroduction: STAT4 is an important transcription factor that activates gene transcription as a response to cytokines. Recently, the influence of STAT4 gene on autoimmune disease has been widely studied in many different immune-related diseases. Autoimmune, metabolic and cardiovascular disorders are more common in psoriatic patients. STAT4 may be a unique gene that switches on in autoimmune-related thyroid disease in psoriatic patients. The aim of the study: To explore the association of a STAT4 rs7574865 polymorphism to autoimmune thyroid diseases in the general Turkish population and psoriatic subgroups. Material and methods: A total of 132 psoriatic patients and 118 non-psoriatic volunteers were genotyped for STAT4 rs7574865 using real time PCR. Twenty-four of the psoriatic patients and 15 of the non-psoriatic volunteers have autoimmune-related thyroid diseases. Results: The prevalence of the T allele [OR = 4.37; 95% CI: 1.05-19; p = 0.03] of the STAT4 rs7574865 was higher in individuals with autoimmune-related thyroid diseases among the all non-psoriatic volunteers. The volunteers with autoimmune-related thyroid diseases has an increased allele positivity and carriers having at least one of the risk allele was significantly higher than in counterparts with a GG wild genotype [ORGT/TT vs. GG: 1.73; 95% CI: 0.09-32; p = 0.03]. Yet, there was no evidence of an association between rs7574865 and autoimmune-related thyroid disease in psoriatic patients. Conclusions: The STAT4 rs7574865 polymorphism increases autoimmune-related thyroid disease susceptibility among the general population but not in psoriatic patients.Öğe Correlation between psoriasis and ZIP2 and ZIP3 Zinc transporters(Wolters Kluwer Medknow Publications, 2020) Kilic, Sevilay; Sehitoglu, Hilal MuserrefAims: Psoriasis is a chronic, inflammatory, hyperproliferative skin disease with etiopathogenesis not fully understood. The zinc transporter ZIP2 is associated with keratinocyte differentiation, whereas ZIP3 is associated with T-lymphocyte maturation. In our study, we aimed to show the correlation between psoriasis and ZIP2 and ZIP3 zinc transporters in psoriasis patients. Subjects and Methods: The patient group in the study included 60 patients aged with psoriasis vulgaris and a control group of 60 healthy adults. The levels of ZIP2 (SLC39A2) and ZIP3 (SLC39A3) zinc transporters were determined with the ELISA method. Results were compared with control group values and statistically assessed. Results: When the ZIP2 and ZIP3 levels are compared in controls and psoriasis patients, the levels were observed to significantly increase compared to controls (P < 0.05). When compared to the control group, the results appeared to be statistically significant (P < 0.05). Conclusions: With etiopathogenesis not fully known, there may be an important relationship between psoriasis development and ZIP2 (SLC39A2) and ZIP3 (SLC39A3) zinc transporters in psoriasis vulgaris patients. This situation may be an important result for understanding how the disease develops and in creating new approaches in terms of treatment for this disease without full cure available.Öğe Dramatic Response to Methyl Prednisolone of Sacroiliitis due to Isotretinoin Theraphy: A Case Report(Galenos Yayincilik, 2020) Resorlu, Hatice; Kilic, Sevilay; Zateri, CoskunAcne vulgaris is a disorder that affects the pilosebaceous follicles on the skin. Isotretinoin is used in the treatment of severe acne and it may have side effects such as arthritis, myalgia, hyperostosis, sacroiliitis in the musculoskeletal system. Rarely seen sacroiliitis is usually recovered by discontinuation of isotretinoin. In this article, it was presented that a 19-year-old patient with bilateral and widespread sacroiliitis as a result of isotretionin use. Despite the use of non-steroidal anti-inflammatory drugs, sacroiliitis, which did not regress, responded dramatically to methyl prednisolone treatment.Öğe Dyspepsia, Irritable Bowel Syndrome, and Hematological Parameters in Recurrent Aphthous Stomatitis(Derman Medical Publ, 2017) Kilic, Sevilay; Cevizci, Sibel; Sen, Hacer; Isik, Selda; Gunes, Fahri; Binnetoglu, Emine; Hiz, Meliha MerveAim: The goal of this study was to investigate the relationship between gastrointestinal complaints (dyspepsia, irritable bowel syndrome) and hematological parameters among recurrent aphthous stomatitis (RAS) patients. Material and Method: Forty-four RAS patients with a diagnosis of recurrent oral ulcers in oral mucosa were included in this study. They answered a questionnaire concerning oral aphthous properties, dyspepsia problems, and irritable bowel syndrome. Routine hematological screening and hemoglobin, vitamin B12, folic acid, and TSH were analyzed retrospectively. Data analyses were performed using SPSS. Results: Constipation complaints by females were statistically more frequent than those of males (59.3% vs. 11.8%; p< 0.05). There was a positive, statistically moderate and significant correlation between the time passed without having an aphtha (r= 0.343; p= 0.026) and lymphocyte level (r= 0.383; p= 0.028). However, there was no association between the time passed without having an aphtha and age (r= 0.112; p= 0.473), aphtha recurrence frequency (r= 0.05; p= 0.738), vitamin B12 (r= 0.019; p= 0.929), and Hb levels (r= 0.047; p= 0.781). Discussion: It was determined that there was positive correlation between aphtha size and lymphocyte level. Further studies should be designed in light of the association of RAS and gastrointestinal system disease.Öğe Evaluation of Macular Ganglion Cell-inner Plexiform Layer and Choroid in Psoriasis Patients Using Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography(Taylor & Francis Inc, 2017) Ersan, Ismail; Kilic, Sevilay; Arikan, Sedat; Kara, Selcuk; Isik, Selda; Gencer, Baran; Ogretmen, ZerrinPurpose: To evaluate changes in the thickness of the central macula, macular ganglion cell-inner plexiform layer (mGCIPL), and subfoveal choroid in patients with psoriasis using spectral domain optical coherence tomography (SD-OCT). Methods: The measurements of macular, mGCIPL thicknesses and subfoveal choroidal thickness (SFCT) obtained by SD-OCT of psoriasis patients (n = 46). These measurements were compared with those of 50 healthy controls. Results: The macular, mGCIPL, and choroidal thicknesses did not differ between the controls and psoriatic subjects (p>0.05). When the patients were divided into two distinct groups, only the SFCT was significantly thicker in the severe psoriasis group compared with the mild psoriasis group (p = 0.003). Conclusions: These findings suggest that choroidal alterations are seen without macular changes in patients with psoriasis. Severe psoriasis appears to be related to increases in SFCT as a consequence of possible inflammatory cascades that are part of the disease's pathogenesis.Öğe Evaluation of ocular surface epithelial and stromal thicknesses in psoriasis using anterior segment optical coherence tomography(Springer, 2022) Ersan, Ismail; Kilic, Sevilay; Isik, SeldaPurpose To evaluate the epithelial and stromal thicknesses of conjunctiva and cornea in psoriatic patients with anterior segment optical coherence tomography (AS-OCT), Methods In this cross-sectional study, 61 patients with psoriasis and 42 age-matched, healthy individuals were enrolled. The epithelial and stromal thicknesses of both inferotemporal bulbar conjunctiva and central cornea were measured using AS-OCT. Results Both the tear breakup time and Schirmer-1 test values were significantly lower in the psoriasis group compared with the controls (p < 0.05). The epithelial thickness of conjunctiva and cornea did not differ between psoriasis and control groups (p > 0.05). The central corneal stroma was significantly thicker in the psoriasis group (p = 0.04). PASI was positively correlated with the thickness of central cornea stroma (r = 0.442, p = 0.006) in the nail psoriasis group. Conclusions Psoriasis is not associated with altered epithelial thicknesses of the cornea and conjunctiva. It is accompanied by the stromal thickening of the cornea without conjunctival stromal involvement.Öğe Habits of Using Social Media and the Internet in Psoriasis Patients(Mattioli 1885, 2022) Kayiran, Melek Aslan; Karadag, Ayse Serap; Topal, Ilteris Oguz; Adisen, Esra; Kilic, Sevilay; Keskin, Nuray; Polat, Asude KaraIntroduction: Psoriasis significantly affects the patients quality of life, which often leads patients to seek online information about this disease. Objectives: To explore the habits of patients with psoriasis related to their use of social media (SM) and the internet to obtain information about their disease. Methods: 1,520 patients completed the survey and the Dermatology Life Quality Index (DLQI) -questionnaire. The Psoriasis Area Severity Index scores (PASI) and clinical data of the patients were recorded by their physicians. Results: Of the 1,114 patients that reported using SM and internet, 48.38% regularly and 31.14% sometimes resorted to obtain information about psoriasis. The use of SM and internet for psoriasis was statistically significantly higher among young people (P = 0.000), those with university or higher education (P = 0.009), higher DLQI (P = 0.000) and PASI (P = 0.011) scores, facial (P = 0.050), scalp (P = 0.032), hand (P = 0.048), genital (P = 0.001) and inverse (P = 0.000) involvement, and arthralgia/arthritis (P = 0.006). The participants mostly used the Google (86%) and Facebook (41%). More than half of the participants (62.8%) expected dermatologists to inform society that psoriasis is not contagious. Conclusions: Internet and SM being widely available and offering substantial information to be easily accessed make it very attractive for patients to use these platforms to investigate diseases, including psoriasis. If what is presented on SM conflicts with what the physician says, patients mostly trust the latter, but at the same time, they tend not to share the results of their online inquiries with their physicians.Öğe Is there any increased risk of hypertension, diabetes and cardiac diseases in psoriatic patients with TNF-? G238A and G308A polymorphism?(Termedia Publishing House Ltd, 2016) Isik, Selda; Hiz, Meliha Merve; Kilic, Sevilay; Ogretmen, Zerrin; Sılan, FatmaIntroduction: Psoriasis is regarded as a complex autoimmune disease with strong genetic background. Psoriatic patients suffer from many comorbidities including hypertension, diabetes and cardiovascular diseases. Cytokines such as tumor necrosis factor alpha (TNF-alpha) may be a key player that triggers psoriasis and diabetes, hypertension and cardiac disease at the same time. Aim: To evaluate genetic variations in the TNF-alpha region and its association with psoriasis and related comorbidities. Material and methods: The study covered 129 psoriasis patients with three main subgroups with coronary artery disease (n = 41), hypertension (n = 35), and diabetes (n = 21). DNA samples were genotyped for TNF-alpha G308A and G238A polymorphisms by real-time polymerase chain reaction melting-curve analysis and results were compared statistically. Results: Psoriatic patients with both TNF-alpha-298 and TNF-alpha-308 polymorphisms showed no statistically significant increase in the risk of hypertension (OR = 0.425, chi(2) = 1.76, p = 0.18 and OR = 1.87, chi(2) = 1.33, p = 0.25), coronary artery disease (OR = 1.97, chi(2) = 1.91, p = 0.17 and OR = 2.63, chi(2) = 1.35, p = 0.25), or diabetes (OR = 1.35, chi(2) = 0.24, p= 0.62 and OR = 1.53, chi(2) = 0.24, p = 0.62). Conclusions: The current preliminary results suggested that there was no correlation between TNF-alpha promoter polymorphism and diabetes, hypertension and cardiac disease among psoriatic patients in the Turkish population.Öğe Patient Use of Complementary and Alternative Medicine for Psoriasis Vulgaris and Factors Believed to Trigger the Disease: a Multicenter Cross-Sectional Study With 1621 Patients(Mattioli 1885, 2022) Kayiran, Melek Aslan; Karadag, Ayse Serap; Topal, Ilteris Oguz; Emre, Selma; Adisen, Esra; Kilic, Sevilay; Keskin, NurayIntroduction: Due to the chronic recurrent nature of psoriasis vulgaris (PV) and lack of definitive treatment for the disease, patients often resort to alternative treatments. Physicians seem to have low awareness of this issue. Objectives: To elicit the perceptions of 1,621 PV patients on complementary and alternative medicine (CAM) and examine factors reported to worsen PV. Methods: The patients sociodemographic characteristics, Psoriasis Area Severity Index (PASI), Dermatology Life Quality Index (DLQI), disease duration, and severity were recorded, and the patients CAM use was questioned in detail. The patients were also asked about factors that worsened PV and their experiences with a gluten-free diet. Results: Of the patients, 56.51% had used CAM. The mean age, illness duration, PASI scores and DLQI of those using CAM were significantly higher. CAM use was significantly higher in those with facial, genital involvement, and arthralgia/arthritis. The patients mostly referred to CAM when PV became severe (46.4%). Of the CAM users, 45.52% used herbal topicals. The physicians of 67.03% did not inquire whether they used CAM. Of the participants, 37.73% considered that stress worsened their disease. Gluten-free diet did not affect PV symptoms in 52.22%. Conclusions: Patients CAM use is often overlooked by dermatologists. Our results showed that more than half the patients used CAM and did not share this information with their physicians. Therefore, the awareness of physicians should be increased and patients should be asked about the use of CAM and directed to the appropriate medical treatment options by physicians.Öğe Psoriatic Arthritis in Psoriasis Patients: Evaluation of Clinical and Radiological Features(Galenos Yayincilik, 2016) Resorlu, Hatice; Ogretmen, Zerrin; Kilic, Sevilay; Akbal, Ayla; Zateri, Coskun; Cevizci, SibelObjective: The purpose of this study was to perform radiological and clinical determination of the presence of psoriatic arthritis (PsA) in patients with psoriasis and to evaluate associations with clinical findings. Materials and Methods: The medical files of 72 patients with psoriasis presenting to our clinic between years 2009-2014 with a prediagnosis of PsA were reviewed retrospectively. Hand, foot and sacroiliac joint radiograms were evaluated by a radiologist who was blinded to the patient's clinical status and who is experienced on musculoskeletal radiology. Patients with psoriasis were divided into two groups according to the presence of arthritis which was determined based on radiographic findings or on Classification Criteria for Psoriatic Arthritis (CASPAR) criteria. All patients' demographic characteristics, length of disease, nail involvement, smoking-alcohol consumption were recorded. Results: The mean age of all patients was 47.24 +/- 14.61 years, and the mean duration of disease was 14.13 +/- 11.92 years. Smoking and alcohol consumptions were determined in 54.2% (n=39) and 23.6% (n=17) of the cases, respectively. Nail involvement was determined in 56.9% (n=41) of the cases. PsA was determined based on radiological findings in 58.3% (n=42) of the patients. The mean age and age at onset of disease were higher in PsA (+) patients than in radiologically non-PsA subjects. Based on clinical findings, PsA based on CASPAR criteria was determined in only 18.1% (n=13) of all patients. Conclusion: A higher level of PsA was determined using radiological evaluation in this study. The main cause of this condition is the existence of asymptomatic-subclinical patients. A detailed medical history should therefore be taken from patients, and good clinical evaluation is very important. Radiological and clinical evaluation should be performed together in the diagnosis.Öğe Pustulotic arthro-osteitis (Sonozaki Syndrome): A rare case report(Ios Press, 2017) Resorlu, Hatice; Inceer, Besir Sahin; Kilic, Sevilay; Isik, SeldaPustulotic arthro-osteitis is a rare disease involving the skin and musculoskeletal system that was first described by Sonozaki. Onset is frequently seen at age 30-40. The prevalences between the sexes are similar. Palmoplantar pustulosis and sternoclavicular joint involvement are the most typical findings. It may be difficult to distinguish seronegative spondyloarthropathies and SAPHO syndrome due to sacroiliac joint, vertebral column and peripheral joint involvement. Arthritis being non-erosive and short-lived in character and the absence of deformity or contracture in the joints are significant clinical characteristics. Antiinflammatory and immunesuppressive drugs are used in the treatment of the disease, the course of which involves remission and flare-ups. We describe the case of a 43-year-old male patient diagnosed with pustulotic arthro-osteitis.Öğe Sarcoidosis Revealed with Skin Manifestations and Acute Arthritis(Galenos Yayincilik, 2019) Resorlu, Hatice; Kilic, Sevilay; Zateri, CoskunA 37-year-old female patient admitted to our clinic with swelling in both knees and ankles and eruptions in her body. The patient was examined for the etiology of arthritis. In the biopsy taken from the plaque lesions on the skin, granulomatous sarcoidal lesions were detected. The case was diagnosed as sarcoidosis along with clinical, laboratory, and radiological findings. Sarcoidosis started with skin involvement is rarely seen in the literature. Biopsy from specific skin lesions allows diagnosis without the need for an invasive transbronchial biopsy. Therefore, we aimed to present a case of sarcoidosis diagnosed with skin manifestations.Öğe Skin Prick Test Results of Canakkale Onsekizmart University Faculty of Medicine Dermatology Department(Derman Medical Publ, 2015) Isik, Selda; Ogretmen, Zerrin; Kilic, Sevilay; Cevizci, SibelAim: In this study we aimed to evaluate the prick test results of the patients with chronic urticaria, allergic rhinitis, sinusitis conjunctivitis, pharyngitis, allergic asthma and atopic dermatitis who attended to dermatology department of Canakkale Onsekiz Mart University Faculty of Medicine. Material and Method: The prick test results of 583 patients with chronic urticaria, allergic rhinitis, sinusitis, conjunctivitis, pharyngitis, allergic asthma, atopic dermatitis were assessed retrospectively for this study. 50 standard allergens including pollens, grass, weed, fungal allergens, latex, cat fur, dog hair, house dust mites and foods were performed to the patients. Results: The ages of the patients were between 3 and 70 (mean age was 30.6 +/- 17.5). At least one positive prick test result to any allergen were obtained in 359 patients (61.6%). The most common allergens were; house dust mites (50.5%), weed(28.8%), polen grains(29%), tomato (13.7%), coffee (13.1%), chicken meat (13.0%) and chocolate (12.7%), respectively. Discussion: We think that our study will help to contribute to the allergen map of our country.Öğe Successful infliximab therapy in a patient with comorbid spondyloarthritis, primary biliary cirrhosis and generalized morphea(Taylor & Francis Ltd, 2017) Resorlu, Hatice; Kilic, Sevilay; Isik, Selda; Gokmen, FerhatThe patient in this report was diagnosed simultaneously with primary biliary cirrhosis (PBC), spondyloarthritis, and generalized morphea and was started on infliximab therapy. In addition to an improvement in clinical symptoms with this therapy, an improvement was also observed in laboratory parameters such as cholestatic enzymes, C-reactive protein, and erythrocyte sedimentation rate. Infliximab was well tolerated in this 56-year-old patient. However, further studies must be performed in order to clarify the therapeutic role of TNF- blockers in, PBC and generalized morphea.Öğe The correlation between the psoriasis area severity index and ischemia-modified albumin, mean platelet volume levels in patients with psoriasis(Termedia Publishing House Ltd, 2016) Isik, Selda; Kilic, Sevilay; Ogretmen, Zerrin; Cakir, Dilek Ulker; Turkon, Hakan; Cevizci, Sibel; Hiz, Meliha MerveIntroduction: Ischemia-modified albumin (IMA), a novel ischemia marker, and mean platelet volume (MPV), a determinant of platelet activation, have been reported as elevated markers in cardiovascular risk factors such as atherosclerosis, metabolic syndrome, diabetes mellitus (DM), hypertension, and dyslipidemia. As psoriasis is a chronic inflammatory disease having comorbidities, IMA and MPV can help determine the risk factors for psoriasis. Aim: To investigate the correlation between the psoriasis area severity index (PASO, IMA and MPV levels in patients with psoriasis. Material and methods: This cross-sectional, case-control study was performed between January 2014 and December 2014 at the University hospital in Canakkale, Turkey. Forty-five patients with psoriasis and 44 healthy volunteers over 18 years of age were included in the study. In the psoriasis patient group, clinical features and PASI scores were recorded. Serum IMA and MPV concentrations were evaluated in both groups. Results: The mean IMA values were 0.85 +/- 0.15 and 0.79 +/- 0.09 (in the psoriasis patients and control groups, respectively), and there was a statistically significant difference (p = 0.048). Ischemia-modified albumin levels were not correlated with PASI scores (r = 0.024; p = 0.889) but were correlated with disease duration (r = 0.323; p = 0.048). There was no statistically significant difference between the MPV values of the two groups (8.98 +/- 1.14 and 9.19 +/- 1.28 in the psoriasis patients and control groups, respectively) (p = 0.435). Conclusions: Ischemia-modified albumin may be used as a marker for detecting oxidative stress in patients with psoriasis, especially those with a long disease duration.Öğe The importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis(Wiley, 2022) Gul, Ceren; Kilic, Sevilay; Sehitoglu, Muserref HilalBackground Psoriasis is a chronic inflammatory skin disorder characterized by inflammation, hyperproliferation and neoangiogenesis. The disease pathogenesis has not been fully elucidated. The proteins, a disintegrin and metalloproteinase (ADAM)10 and ADAM17, are important proteases serving as regulators of inflammation. Aim To determine the role of ADAM10 and ADAM17 in the pathogenesis of psoriasis through the comparison of their serum levels in patients with psoriasis and healthy controls (HCs). Methods In total, 179 participants (90 patients with psoriasis and 89 HCs) were enrolled in the study. Levels of ADAM10 and ADAM17 in serum were measured by ELISA for each participant from the patient and HC groups. The statistical data analysis was performed using SPSS (V19.0) and P < 0.05 was considered statistically significant. Results The mean values for serum ADAM10 and ADAM17 were, respectively, 3.1 +/- 2.2 and 76.5 +/- 31.1 in the psoriasis group and 8.6 +/- 3.7 and 29.5 +/- 22.4 in the HC group. A statistically significant difference between the patient and HC groups was detected for both ADAM10 and ADAM17 levels (P = 0.001). Conclusion Considering the high levels of ADAM17 in the psoriasis group, ADAM17 protease might have a crucial role in the pathogenesis of psoriasis, while the low levels of ADAM10 might be attributable to its regulatory effect on keratinocyte differentiation and proliferation.
