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    Enantioselective synthesis of new chiral 2-aziridinyl phosphonates and studies of their biological activities
    (Pergamon-Elsevier Science Ltd, 2017) Dogan, Ozdemir; Cakir, Sidika Polat; Beksultanova, Nurzhan; Altanlar, Nurten; Simsek, Duygu; Karabiyik, Hasan
    A new series of chiral aziridinyl phosphonates has been synthesized and evaluated for antibacterial and antifungal activities. For the synthesis, a Gabriel-Cromwell reaction was used to form aziridinyl phosphonates in 52-83% yield. In order to evaluate antibacterial and antifungal activities, MIC values were measured. Although most of the compounds showed insignificant activity, two of them provided low to moderate antifungal activity. (C) 2017 Elsevier Ltd. All rights reserved.