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Öğe 308G/A and 238G/A polymorphisms in the TNF-? gene may not contribute to the risk of arthritis among Turkish psoriatic patients(Elsevier Science Bv, 2016) Isik, Selda; Sılan, Fatma; Kilic, Sevilay; Hiz, Meliha Merve; Ogretmen, Zerrin; Özdemir, ÖztürkIntroduction: Tumor necrosis factor-alpha (TNF-alpha) is an important proinflammatory cytokine playing a key role in the pathogenesis of psoriasis (Ps) and psoriatic arthritis (PsA). TNF alpha gene promoter region single nucleotide polymorphisms (SNPs) affect the clinical course, severity and the response to the treatment. Aim of the work: To find out whether TNF-alpha-238G/A and -308G/A promoter polymorphism in Ps patients increases arthritis risk. Patients and methods: The study included 129 psoriatic patients (71 with psoriasis only and 58 with PsA). Two single nucleotide polymorphisms in the TNF alpha gene promoter region (238G/A and -308G/A) were genotyped by real-time polymerase chain reaction. Results: Ps patients without arthritis had a mean age of 44.20 +/- 13.85 years (range 18-68 years), while PsA patients had a mean age of 49.15 +/- 13.47 years (range 18-82 years) and presented by dactylitis (67.2%), enthesitis (62.1%) followed by spondylitis (60.3%). Periosteal reaction was present in 19%. The psoriatic arthritis severity index (PASI) was comparable between those with (8.2 +/- 7.1) and without (7.3 +/- 5.12.1) arthritis. The allele positivity of TNF-238A and -308A was not associated with the risk of arthritis among psoriatic patients (OR: 1.002; 95% CI: 0.38-2.6, p=0.99 and OR: 1.27; 95% CI: 0.51-3.2, p=0.6, respectively). In addition, none of the genotypes of the studied TNF-alpha polymorphisms were significantly associated with arthritis. Only spondylitis was significantly associated more frequently with the GG (67.3%) than the GA (22.2%) TNF-alpha-308G/A genotype (p=0.02). Conclusion: None of the haplotypes nor alleles of TNF-alpha-238G/A and -308G/A polymorphisms were significantly associated with arthritis development among psoriatic patients. (C) 2016 Egyptian Society of Rheumatic Diseases. Publishing services provided by Elsevier B.V.Öğe A comparison of a 5% potassium hydroxide solution with a 5-fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open-label clinical trial(Wiley, 2014) Isik, Selda; Koca, Rafet; Sarici, Gulben; Altinyazar, Hilmi CevdetAnogenital warts are caused by human papillomavirus (HPV), over 30 types of which are infectious for the anogenital tract. Without treatment, warts may regress spontaneously, remain unchanged, or increase in number and size. This study compared the efficacy of a topical 5% potassium hydroxide (KOH) solution with that of a topical 0.5% 5-fluorouracil (5-FU) and 10% salicylic acid (SA) combination in the treatment of anogenital warts. Sixty patients were randomly assigned to receive topical KOH or 5-FU + SA. Both groups demonstrated a significant decrease in numbers of lesions (P < 0.05), but this difference was not significant at week 12 (P > 0.05). The mean number of lesions decreased from baseline to week 12 from 17.03 +/- 12.64 to 3.73 +/- 7.30 and from 16.13 +/- 12.97 to 3.10 +/- 4.90 in the KOH and 5-FU + SA groups, respectively (P < 0.001). Excellent clearance was achieved by 70.0 and 76.7% of patients in the KOH and 5-FU + SA groups, respectively. Marked improvement was seen in 13.3 and 20.0% of patients in the KOH and 5-FU + SA groups, respectively. At week 16, relapse was observed in two patients in the KOH group and three in the 5-FU + SA group (P > 0.05). No serious adverse events were reported. Neither treatment was more efficacious. Safety and ease of application are important goals in treatments for anogenital warts. A 5% KOH solution is a promising alternative treatment because it is effective and inexpensive and causes minimal side effects.Öğe Alopesia areatalı hastalarda metakognisyonun değerlendirilmesi(2016) Akyol, Esra Soydas; Isik, Selda; Ertekin, Hülya; Şahin, Başak; Oğuz, Sevilay; Cevizci, SibelAmaç:Genetik ve çevresel faktörler üzerinde durulsa da patogenezi tam olarak bilinmeyen alopesi areatanın(AA) emosyonel stres ile birlikteliği sıktır. AA da en sık rastlanan psikiyatrik bozuklukların depresyon ve anksiyete bozukluğu olduğu bilinmektedir. Alopesi areata ile psikiyatrik hastalıkların sıklıkla birlikteliği göz önüne alındığında pek çok psikiyatrik hastalığın kaynağını oluşturan metakognisyonun hastalığın etiyolojisinde etkin bir rol oynayabileceği kanaatini taşımaktayız. Gereç ve Yöntem:Çalışmaya 50 alopesi areata tanılı hasta ve 50 sağlıklı gönüllü alındı. Her iki gruba, tarafımızca hazırlanmış olan Sosyodemografik Veri formu ve Üstbiliş Ölçeği (ÜBÖ-30), alopesi areata grubuna ise ek olarak DSM IV Yapılandırılmış Klinik Görüşme Formu I (SCID-I) uygulandı. İki grup sosyodemografik ve klinik özellikler ile metacognisyon özellikleri açısından karşılaştırıldı. Bulgular:Sosyodemografik veriler değerlendirildiğinde Ailede AA ve psikiyatrik hastalık varlığı dışında gruplar arasında anlamlı bir farklılık saptanmadı. Bu iki özellik ise AA tanılı grupta SG grubuna oranla anlamlı şekilde yüksek bulundu. Düşünceleri kontrol ihtiyacı alt skoru AA grubunda SG grubuna kıyasla anlamlı oranda yüksek olarak saptanmıştır(p=0.022). AA hastalarının, tutulum yüzdesine göre karşılaştırıldığında; gruplar arasında kontrol edilmezlik ve tehlike, düşünceleri kontrol ihtiyacı ve bilişsel farkındalık skorları açısından anlamlı fark bulunmaktaydı ( p=0,01; P=0.002, p=0,009) AA hastaları remisyonu olup olmamasına göre karşılaştırıldığında bilişsel farkındalık alt skorlarında remisyonu olmayan grupta daha yüksek olmak üzere anlamlı bir fark bulunmaktaydı (p=0.018). Sonuç:Psikosomatik bir hastalık olduğu bilinen AA nın psikiyatrik açıdan araştırılmamış pek çok yönü olduğu kanaatindeyiz. Çalışmamız metakognisyon konusunda bir ön çalışma niteliğinde olup, metakognisyonla birlikte diğer psikiyatrik hastalıkların(OKB, YAB) beraberliğinin araştırılmasının AAnın daha iyi anlaşılmasında daha fazla yol gösterici olacağını düşünmekteyiz.Öğe Association between mean platelet volume and disease severity in patients with psoriasis and psoriatic arthritis(Termedia Publishing House Ltd, 2017) Kilic, Sevilay; Resorlu, Hatice; Isik, Selda; Oymak, Sibel; Akbal, Ayla; Hiz, Meliha Merve; Ogretmen, ZerrinIntroduction: Mean platelet volume (MPV) is an important marker that shows the activation and function of the platelets, which is effective in the inflammatory diseases. Aim: To show the relationship between MPV and the development of psoriatic arthritis (PA) in patients with psoriasis vulgaris (PV) and the correlation between MPV and psoriasis severity score (PASI). Material and methods: Our study included 116 patients with psoriatic arthritis (68 female, 48 male) and 41 patients in the psoriasis group (19 female, 22 male) and 90 subjects in the control group (55 female, 35 male). The demographic data of the patients, duration of disease, PAS', the nature of the disease were evaluated retrospectively. Results: Mean platelet volume levels of both the PV group (8.79 +/- 0.86 fl) and the PA group (9.18 +/- 1.26 fl) were significantly higher compared to the control group (8.42 +/- 0.74 fl). There was a weak statistically positive correlation between the PASI and the MPV according to the correlation analysis (r = 0.165; p = 0.046). Conclusions: Our results show that MPV may be helpful as an indicator of the clinical course of PV and PA. In this regard, that study should be supported by prospective studies to find strong correlations.Öğe Authors reply to Letter to the Editor-In response to: Ersan I, Kilic S, Arikan S, et al. Evaluation of macular ganglion cell-inner plexiform layer and choroid in psoriasis patients using enhanced depth imaging spectral domain optical coherence tomography(Taylor & Francis Inc, 2017) Ersan, Ismail; Kilic, Sevilay; Arikan, Sedat; Kara, Selcuk; Isik, Selda; Gencer, Baran; Ogretmen, Zerrin[Anstract Not Available]Öğe Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups(Termedia Publishing House Ltd, 2015) Hiz, Meliha M.; Kilic, Sevilay; Isik, Selda; Ogretmen, Zerrin; Sılan, FatmaIntroduction: STAT4 is an important transcription factor that activates gene transcription as a response to cytokines. Recently, the influence of STAT4 gene on autoimmune disease has been widely studied in many different immune-related diseases. Autoimmune, metabolic and cardiovascular disorders are more common in psoriatic patients. STAT4 may be a unique gene that switches on in autoimmune-related thyroid disease in psoriatic patients. The aim of the study: To explore the association of a STAT4 rs7574865 polymorphism to autoimmune thyroid diseases in the general Turkish population and psoriatic subgroups. Material and methods: A total of 132 psoriatic patients and 118 non-psoriatic volunteers were genotyped for STAT4 rs7574865 using real time PCR. Twenty-four of the psoriatic patients and 15 of the non-psoriatic volunteers have autoimmune-related thyroid diseases. Results: The prevalence of the T allele [OR = 4.37; 95% CI: 1.05-19; p = 0.03] of the STAT4 rs7574865 was higher in individuals with autoimmune-related thyroid diseases among the all non-psoriatic volunteers. The volunteers with autoimmune-related thyroid diseases has an increased allele positivity and carriers having at least one of the risk allele was significantly higher than in counterparts with a GG wild genotype [ORGT/TT vs. GG: 1.73; 95% CI: 0.09-32; p = 0.03]. Yet, there was no evidence of an association between rs7574865 and autoimmune-related thyroid disease in psoriatic patients. Conclusions: The STAT4 rs7574865 polymorphism increases autoimmune-related thyroid disease susceptibility among the general population but not in psoriatic patients.Öğe Dyspepsia, Irritable Bowel Syndrome, and Hematological Parameters in Recurrent Aphthous Stomatitis(Derman Medical Publ, 2017) Kilic, Sevilay; Cevizci, Sibel; Sen, Hacer; Isik, Selda; Gunes, Fahri; Binnetoglu, Emine; Hiz, Meliha MerveAim: The goal of this study was to investigate the relationship between gastrointestinal complaints (dyspepsia, irritable bowel syndrome) and hematological parameters among recurrent aphthous stomatitis (RAS) patients. Material and Method: Forty-four RAS patients with a diagnosis of recurrent oral ulcers in oral mucosa were included in this study. They answered a questionnaire concerning oral aphthous properties, dyspepsia problems, and irritable bowel syndrome. Routine hematological screening and hemoglobin, vitamin B12, folic acid, and TSH were analyzed retrospectively. Data analyses were performed using SPSS. Results: Constipation complaints by females were statistically more frequent than those of males (59.3% vs. 11.8%; p< 0.05). There was a positive, statistically moderate and significant correlation between the time passed without having an aphtha (r= 0.343; p= 0.026) and lymphocyte level (r= 0.383; p= 0.028). However, there was no association between the time passed without having an aphtha and age (r= 0.112; p= 0.473), aphtha recurrence frequency (r= 0.05; p= 0.738), vitamin B12 (r= 0.019; p= 0.929), and Hb levels (r= 0.047; p= 0.781). Discussion: It was determined that there was positive correlation between aphtha size and lymphocyte level. Further studies should be designed in light of the association of RAS and gastrointestinal system disease.Öğe Evaluation of Macular Ganglion Cell-inner Plexiform Layer and Choroid in Psoriasis Patients Using Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography(Taylor & Francis Inc, 2017) Ersan, Ismail; Kilic, Sevilay; Arikan, Sedat; Kara, Selcuk; Isik, Selda; Gencer, Baran; Ogretmen, ZerrinPurpose: To evaluate changes in the thickness of the central macula, macular ganglion cell-inner plexiform layer (mGCIPL), and subfoveal choroid in patients with psoriasis using spectral domain optical coherence tomography (SD-OCT). Methods: The measurements of macular, mGCIPL thicknesses and subfoveal choroidal thickness (SFCT) obtained by SD-OCT of psoriasis patients (n = 46). These measurements were compared with those of 50 healthy controls. Results: The macular, mGCIPL, and choroidal thicknesses did not differ between the controls and psoriatic subjects (p>0.05). When the patients were divided into two distinct groups, only the SFCT was significantly thicker in the severe psoriasis group compared with the mild psoriasis group (p = 0.003). Conclusions: These findings suggest that choroidal alterations are seen without macular changes in patients with psoriasis. Severe psoriasis appears to be related to increases in SFCT as a consequence of possible inflammatory cascades that are part of the disease's pathogenesis.Öğe Evaluation of ocular surface epithelial and stromal thicknesses in psoriasis using anterior segment optical coherence tomography(Springer, 2022) Ersan, Ismail; Kilic, Sevilay; Isik, SeldaPurpose To evaluate the epithelial and stromal thicknesses of conjunctiva and cornea in psoriatic patients with anterior segment optical coherence tomography (AS-OCT), Methods In this cross-sectional study, 61 patients with psoriasis and 42 age-matched, healthy individuals were enrolled. The epithelial and stromal thicknesses of both inferotemporal bulbar conjunctiva and central cornea were measured using AS-OCT. Results Both the tear breakup time and Schirmer-1 test values were significantly lower in the psoriasis group compared with the controls (p < 0.05). The epithelial thickness of conjunctiva and cornea did not differ between psoriasis and control groups (p > 0.05). The central corneal stroma was significantly thicker in the psoriasis group (p = 0.04). PASI was positively correlated with the thickness of central cornea stroma (r = 0.442, p = 0.006) in the nail psoriasis group. Conclusions Psoriasis is not associated with altered epithelial thicknesses of the cornea and conjunctiva. It is accompanied by the stromal thickening of the cornea without conjunctival stromal involvement.Öğe Increased Pathological Worry Levels in Patients with Alopecia Areata(Derman Medical Publ, 2017) Sahin, Basak; Soydas, Esra Akyol; Oguz, Sevilay; Isik, Selda; Ertekin, HulyaAim: Alopecia Areata (AA) is a type of hair loss that has been considered to have associations with various psychiatric disorders. In this study, we aimed to compare pathological worry levels between patients with AA and healthy controls (HC). Material and Method: Sixty-three patients with AA and 90 HCs were included in the present study after applying inclusion and exclusion criteria. The socio-demographic characteristics, some clinical characteristics, and the scores from the Penn State Worry Questionnaire (PSWQ) were compared between groups. Results: The demographic characteristics were found to be similar between groups except for gender. The family history of AA was significantly higher in the AA group. The mean score of PSWQ in the AA group was 44.02 +/- 11.59, compared to 39.71 +/- 7.77 in the HC group. The mean score of PSWQ was significantly higher in the AA group (t=-3.27, p= 0.001). Discussion: The present study is the first to compare pathological worry between patients with AA and HCs. We suggest that pathological worry should be more thoroughly investigated in patients with AA to improve their quality of life. Also, this can be an effective approach to targeting the patients who may develop anxiety disorder.Öğe Is there any increased risk of hypertension, diabetes and cardiac diseases in psoriatic patients with TNF-? G238A and G308A polymorphism?(Termedia Publishing House Ltd, 2016) Isik, Selda; Hiz, Meliha Merve; Kilic, Sevilay; Ogretmen, Zerrin; Sılan, FatmaIntroduction: Psoriasis is regarded as a complex autoimmune disease with strong genetic background. Psoriatic patients suffer from many comorbidities including hypertension, diabetes and cardiovascular diseases. Cytokines such as tumor necrosis factor alpha (TNF-alpha) may be a key player that triggers psoriasis and diabetes, hypertension and cardiac disease at the same time. Aim: To evaluate genetic variations in the TNF-alpha region and its association with psoriasis and related comorbidities. Material and methods: The study covered 129 psoriasis patients with three main subgroups with coronary artery disease (n = 41), hypertension (n = 35), and diabetes (n = 21). DNA samples were genotyped for TNF-alpha G308A and G238A polymorphisms by real-time polymerase chain reaction melting-curve analysis and results were compared statistically. Results: Psoriatic patients with both TNF-alpha-298 and TNF-alpha-308 polymorphisms showed no statistically significant increase in the risk of hypertension (OR = 0.425, chi(2) = 1.76, p = 0.18 and OR = 1.87, chi(2) = 1.33, p = 0.25), coronary artery disease (OR = 1.97, chi(2) = 1.91, p = 0.17 and OR = 2.63, chi(2) = 1.35, p = 0.25), or diabetes (OR = 1.35, chi(2) = 0.24, p= 0.62 and OR = 1.53, chi(2) = 0.24, p = 0.62). Conclusions: The current preliminary results suggested that there was no correlation between TNF-alpha promoter polymorphism and diabetes, hypertension and cardiac disease among psoriatic patients in the Turkish population.Öğe Predictive value of striae gravidarum severity for intraperitoneal adhesions or uterine scar healing in patients with previous caesarean delivery(Taylor & Francis Ltd, 2014) Gungor, Ayse Nur Cakir; Oguz, Sevilay; Hacivelioglu, Servet; Isik, Selda; Uysal, Ahmet; Gencer, Meryem; Cosar, EmineObjective: Previous abdominal operations might cause severe intraperitoneal adhesions (IPA), which can complicate caesarean section (CS) procedures. When selecting the mode and timing of delivery, obstetricians are also curious about uterine scar healing if the previous operation was a CS. Uterine scar thickness is an indicator of uterine scar healing. We aimed to evaluate the possible predictive value of striae gravidarum (SG) on IPA formation and uterine scar thickness (UST). Methods: Fifty-five women with a previous CS history were evaluated for SG Davey Score. They were investigated for IPAs and lower segment uterine scar thickness during the current CS operation. Results: Out of the patients with no SG (n = 11), mild SG (n = 10) and severe SG (n = 34), 1 (9.1%), 3 (30%) and 17 (50%) had IPA, respectively (p = 0.044). The mean uterine scar thicknesses in the no SG, mild SG and severe SG groups were 3.82 +/- 4.04, 5.20 +/- 4.13 and 5.18 +/- 3.52, respectively (p = 0.561). Conclusions: To the best of our knowledge, this was the first study to investigate the relationship between SG and IPA and uterine scar thickness. The SG status of a patient with a previous delivery and abdominal operation history might help predict IPA status before planning a new operation.Öğe Prevalence of skin disorders in primary and secondary school age children in Canakkale, Turkey: a community-based survey(Termedia Publishing House Ltd, 2016) Uludag, Aysegul; Kilic, Sevilay Oguz; Isik, Selda; Ertekin, Yusuf Haydar; Tekin, Murat; Cevizci, Sibel; Ogretmen, ZerrinIntroduction: Skin lesions may be of dermatological importance, affect appearance, and cause problems communicating with peers and may be especially more significant in childhood. Aim: Information on the prevalence of pediatric dermatoses in Western Turkey. This study was aimed to define the existing data. Material and methods: A cross-sectional study was conducted in Canakkale, Turkey, in September-December 2013. It involved 1,957 students from five randomly selected primary and secondary schools. Each student was interviewed for age, gender, and family history, and a dermatologic examination was performed by a dermatologist. Data were coded and analyzed. Results: Of the students, 79.9% revealed at least one dermatosis. The most common disease was benign neoplasms (76%), followed by pigmentary disorders (26.8%), and xerosis (5.8%). In primary schools, the acquired melanocytic nevus, hypopigmented macule, and xerosis; in secondary school the acne was statistically significantly more common. Acne and xerosis was more common in girls, and pityriasis alba was statistically more common in boys. Students who had at least one dermatosis were positively correlated with monthly income. Conclusions: In Turkish school age children, the prevalence of dermatosis is 79.9%. It may be due to not using preventive means for adequate protection from the sun and other environmental factors. Infectious dermatosis and atopic dermatitis are rare and it may depend on the adequacy of public health work.Öğe Pustulotic arthro-osteitis (Sonozaki Syndrome): A rare case report(Ios Press, 2017) Resorlu, Hatice; Inceer, Besir Sahin; Kilic, Sevilay; Isik, SeldaPustulotic arthro-osteitis is a rare disease involving the skin and musculoskeletal system that was first described by Sonozaki. Onset is frequently seen at age 30-40. The prevalences between the sexes are similar. Palmoplantar pustulosis and sternoclavicular joint involvement are the most typical findings. It may be difficult to distinguish seronegative spondyloarthropathies and SAPHO syndrome due to sacroiliac joint, vertebral column and peripheral joint involvement. Arthritis being non-erosive and short-lived in character and the absence of deformity or contracture in the joints are significant clinical characteristics. Antiinflammatory and immunesuppressive drugs are used in the treatment of the disease, the course of which involves remission and flare-ups. We describe the case of a 43-year-old male patient diagnosed with pustulotic arthro-osteitis.Öğe Skin Prick Test Results of Canakkale Onsekizmart University Faculty of Medicine Dermatology Department(Derman Medical Publ, 2015) Isik, Selda; Ogretmen, Zerrin; Kilic, Sevilay; Cevizci, SibelAim: In this study we aimed to evaluate the prick test results of the patients with chronic urticaria, allergic rhinitis, sinusitis conjunctivitis, pharyngitis, allergic asthma and atopic dermatitis who attended to dermatology department of Canakkale Onsekiz Mart University Faculty of Medicine. Material and Method: The prick test results of 583 patients with chronic urticaria, allergic rhinitis, sinusitis, conjunctivitis, pharyngitis, allergic asthma, atopic dermatitis were assessed retrospectively for this study. 50 standard allergens including pollens, grass, weed, fungal allergens, latex, cat fur, dog hair, house dust mites and foods were performed to the patients. Results: The ages of the patients were between 3 and 70 (mean age was 30.6 +/- 17.5). At least one positive prick test result to any allergen were obtained in 359 patients (61.6%). The most common allergens were; house dust mites (50.5%), weed(28.8%), polen grains(29%), tomato (13.7%), coffee (13.1%), chicken meat (13.0%) and chocolate (12.7%), respectively. Discussion: We think that our study will help to contribute to the allergen map of our country.Öğe Successful infliximab therapy in a patient with comorbid spondyloarthritis, primary biliary cirrhosis and generalized morphea(Taylor & Francis Ltd, 2017) Resorlu, Hatice; Kilic, Sevilay; Isik, Selda; Gokmen, FerhatThe patient in this report was diagnosed simultaneously with primary biliary cirrhosis (PBC), spondyloarthritis, and generalized morphea and was started on infliximab therapy. In addition to an improvement in clinical symptoms with this therapy, an improvement was also observed in laboratory parameters such as cholestatic enzymes, C-reactive protein, and erythrocyte sedimentation rate. Infliximab was well tolerated in this 56-year-old patient. However, further studies must be performed in order to clarify the therapeutic role of TNF- blockers in, PBC and generalized morphea.Öğe The correlation between the psoriasis area severity index and ischemia-modified albumin, mean platelet volume levels in patients with psoriasis(Termedia Publishing House Ltd, 2016) Isik, Selda; Kilic, Sevilay; Ogretmen, Zerrin; Cakir, Dilek Ulker; Turkon, Hakan; Cevizci, Sibel; Hiz, Meliha MerveIntroduction: Ischemia-modified albumin (IMA), a novel ischemia marker, and mean platelet volume (MPV), a determinant of platelet activation, have been reported as elevated markers in cardiovascular risk factors such as atherosclerosis, metabolic syndrome, diabetes mellitus (DM), hypertension, and dyslipidemia. As psoriasis is a chronic inflammatory disease having comorbidities, IMA and MPV can help determine the risk factors for psoriasis. Aim: To investigate the correlation between the psoriasis area severity index (PASO, IMA and MPV levels in patients with psoriasis. Material and methods: This cross-sectional, case-control study was performed between January 2014 and December 2014 at the University hospital in Canakkale, Turkey. Forty-five patients with psoriasis and 44 healthy volunteers over 18 years of age were included in the study. In the psoriasis patient group, clinical features and PASI scores were recorded. Serum IMA and MPV concentrations were evaluated in both groups. Results: The mean IMA values were 0.85 +/- 0.15 and 0.79 +/- 0.09 (in the psoriasis patients and control groups, respectively), and there was a statistically significant difference (p = 0.048). Ischemia-modified albumin levels were not correlated with PASI scores (r = 0.024; p = 0.889) but were correlated with disease duration (r = 0.323; p = 0.048). There was no statistically significant difference between the MPV values of the two groups (8.98 +/- 1.14 and 9.19 +/- 1.28 in the psoriasis patients and control groups, respectively) (p = 0.435). Conclusions: Ischemia-modified albumin may be used as a marker for detecting oxidative stress in patients with psoriasis, especially those with a long disease duration.Öğe The ischemia modified albumin and mean platelet volume levels in patients with Behcet's disease(Termedia Publishing House Ltd, 2016) Kilic, Sevilay; Isik, Selda; Hiz, Meliha Merve; Cakir, Dilek Ulker; Turkon, Hakan; Cevizci, Sibel; Ogretmen, ZerrinIntroduction: Behcet's disease (BD) is a chronic inflammatory disorder with endothelial dysfunction. Ischemia-modified albumin (IMA) is a marker used in the detection of diseases associated with oxidative stress, vascular endothelial cell dysfunction and ischemia. Mean platelet volume (MPV) signifies the platelet function and activity. Aim: To show whether MPV and IMA are useful in revealing the oxidative stress and the risk of thrombosis in patients with BD. Material and methods: Twenty-six patients with BD and 28 healthy volunteers as a control group over 18 years of age were included in the study. Serum IMA and MPV levels were analyzed in both groups. Results: The mean MPV values were identified as 0.86 +/- 0.15 and 0.82 +/- 0.08 (in the BD and control groups, respectively; p = 0.188) and the mean IMA values were 9.39 +/- 0.73 and 9.17 +/- 1.09 (in the BD and control groups, respectively; p = 0.275). There were no statistically significant differences between the groups. The IMA values of BD patients who were in the active phase were significant as compared to inactive BD patients and control groups (p = 0.041). The IMA and MPV values of the thrombotic patients, non-thrombotic patients and control groups were not significant. Conclusions: Ischemia-modified albumin may be a helpful marker of possible complications during an active period of BD.
