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    Possible association between germline methylenetetrahydrofolate reductase gene polymorphisms and psoriasis risk in a Turkish population
    (Wiley-Blackwell, 2017) Kilic, S.; Ozdemir, O.; Sılan, Fatma; Isik, S.; Yildiz, O.; Karaagacli, D.; Sılan, Coşkun
    Background. Psoriasis is a common chronic inflammatory skin disease caused by genetic and epigenetic factors. There are conflicting results in the literature about the association between psoriasis and the methylenetetrahydrofolate reductase gene (MTHFR), ranging from strong linkage to no association. Aim. To investigate the association between the germline MTHFR polymorphisms C677T and A1298C with psoriasis risk in a Turkish population. Methods. The study enrolled 84 patients with psoriasis and 212 healthy controls (HCs) without any history of psoriasis. DNA was extracted from peripheral blood samples of patients and HCs, and real-time PCR was used for genotyping. Results were compared by Pearson chi(2) test and multiple logistic regression models. Results. The frequency of both the MTHFR 677TT and A1298C (homozygous) genotypes was statistically significantly different from HCs. Point mutations were detected in all patients with early-onset psoriasis (before the age of 20 years). The T allele of MTHFR 677 and the C allele of MTHFR 1298 increased psoriasis risk by 12.4-and 17.0-fold, respectively, in patients compared with HCs. Conclusion. A possible association was detected betweengermline MTHFR 677 C>T and 1298 A>C genotypes and psoriasis risk in a Turkish population. These results need to be confirmed in further studies with larger sample sizes.
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    Stria gravidarum is genetic but not related with collagen gene polymorphism
    (Gene Therapy and Molecular Biology, 2013) Cakir Gungor, Ayse Nur; Oguz, S.; Uludag, A.; Sılan, Fatma; Gencer, M.; Uysal, A.; Isik, S.
    Background: Striae Gravidarum (SG) is a common problem that complicates the pregnancies. We aimed to evaluate the possible etiologic factors of SG and the possible importance of collagen polymorphism on SG. Methods: Totally 151 parous women were evaluated for SG and its possible risk factors and their collagen1A1 (coll 1A1) gene polymorphism were investigated. Results: Risk factors that might affect the striae score were evaluated by univariate variant analysis (ANCOVA) and only the maternal striae history seemed to be related with the stria formation. col 1A1 G2046T polymorphism is frequent in the SG group but the difference was not statistically significant (Odds ratio 1.33, %95CI 0.36-4.86, p=0.66). Conclusion: As the best of our knowledge this is the first study that searches for the relationship between col 1A1 polymorphism and SG. We failed to show a relationship between SG and col 1A1 polymorphism. Gene polymorphisms might be various among the different races and ethnic groups. So studies with either the larger sample size or the other races must be done.
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    Öğe
    Stria Gravidarum Is Genetic But Not Related With Collagen Gene Polymorphism
    (Gene Therapy Press, 2013) Gungor, Cakir A. N.; Oguz, S.; Uludag, A.; Sılan, Fatma; Gencer, M.; Uysal, A.; Isik, S.
    BACKGROUND: Striae Gravidarum (SG) is a common problem that complicates the pregnancies. We aimed to evaluate the possible etiologic factors of SG and the possible importance of collagen polymorphism on SG. METHODS: Totally 151 parous women were evaluated for SG and its possible risk factors and their collagen1A1 (coll 1A1) gene polymorphism were investigated. RESULTS: Risk factors that might affect the striae score were evaluated by univariate variant analysis (ANCOVA) and only the maternal striae history seemed to be related with the stria formation. col 1A1 G2046T polymorphism is frequent in the SG group but the difference was not statistically significant (Odds ratio 1.33, % 95CI 0.36-4.86, p= 0.66). CONCLUSION: As the best of our knowledge this is the first study that searches for the relationship between col 1A1 polymorphism and SG. We failed to show a relationship between SG and col 1A1 polymorphism. Gene polymorphisms might be various among the different races and ethnic groups. So studies with either the larger sample size or the other races must be done.
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    Öğe
    Vitamin D Receptor Gene BSMI, FOKI, APAI, and TAQI Polymorphisms and the Risk of Atopic Dermatitis
    (Esmon Publicidad S A, Dept Allergy & Clin Immunol, Clin Univ Navarra, 2016) Kilic, S.; Sılan, Fatma; Hiz, M. M.; Isik, S.; Ogretmen, Z.; Ozdemir, O.
    Background and Objective: The association between vitamin D receptor (VDR) gene polymorphisms and the risk of skin diseases has been widely studied, yet there is only one study on atopic dermatitis. In this study, we aimed to investigate the association between 4 VDR polymorphisms and atopic dermatitis. Patients and Methods: This cross-sectional case control study was performed between March 2013 and April 2014 at the University Hospital in canakkale, Turkey. Peripheral blood samples were collected in EDTA tubes. DNA extraction was performed using the spin column procedure. The VDR polymorphisms Fokl (rs2228570), Bsml (rs1544410), Apal (rs7975232), and Taql (rs731236) were determined by polymerase chain reaction-restriction fragment length polymorphism analysis in 42 atopic dermatitis patients and 96 healthy individuals from a Turkish population. Results: The VDR rs1544410 polymorphism increased the risk of atopic dermatitis in our Turkish population [OR, 12.2; 95%CI, 0.44-336; P=.05]. The Foql, Taql, and Apal polymorphisms were not significantly associated with atopic dermatitis susceptibility. Conclusion: The VDR Fok1, Taql, and Apal gene polymorphisms were not associated with the risk of atopic dermatitis in the Turkish population but the Bsml polymorphism was found to increase risk.