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    Enhancing curcumin's efficacy with zinc oxide nanoparticles: A dynamic duo in combatting disease
    (Elsevier, 2025) Nejabat, Mojgan; Hadizadeh, Farzin; Karav, Sercan; Kesharwani, Prashant; Sahebkar, Amirhossein
    The combination of Zinc Oxide Nanoparticles (ZnO NPs) and Curcumin (Cur) has garnered significant attention due to its therapeutic potential (e. g., cancer treatment, wound healing, and antioxidant applications). CUR has been highly regarded as a natural compound with pharmacological properties such as anticancer, antimicrobial, and antioxidant effects; however, its clinical applications are limited due to its low solubility and bioavailability. In this review, the potentials of CUR and ZnO NPs in the case of biomedical applications were taken into consideration. There have been many attempts to integrate ZnO NPs and CUR for enhancing the mentioned drawbacks of CUR. The effectiveness of ZnO-Cur (CUR/ZnO NPs) nanocomposites, particularly in cancer therapies has been very promising. These nanocomposites exhibit selective toxicity towards cancer cells, with their pH-sensitive release mechanism proving advantageous in targeting the acidic tumor microenvironment. In addition to these effects, CUR/ZnO NPs have antioxidant activity, induce apoptosis in cancer cells, and promote wound healing. The use of ZnO and ZnO-Cur composites led to notable improvements across various applications such as osteoblast viability increased by approximately 60%, Cur release improved by 150%, and osteosarcoma inhibition enhanced by 300%. In agricultural use, ZnO NPs increased silybin content and plant yield while sperm cryopreservation studies showed improved post-thaw quality with ZnO-Cur by measurable margins, significantly. The role of ZnO in boosting Cur bioavailability, therapeutic efficacy, and targeted delivery potential have been confirmed in several studies. However, there are many unsolved challenges such as scalability, cytotoxicity data, and toxicity at higher concentrations that need to be addressed.
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    Recent advances in copolymeric systems for Curcumin delivery: enhancing solubility and bioavailability
    (Springer, 2025) Nejabat, Mojgan; Hadizadeh, Farzin; Karav, Sercan; Kesharwani, Prashant; Sahebkar, Amirhossein
    Curcumin (CUR) has been introduced as a powerful anti-inflammatory and antioxidant compound found extractable from turmeric with advantageous effects for brain health, heart health, immunity, and digestion. Ample evidence has demonstrated CUR's effects on preventing cancer, controlling diabetes, and improving skin health. The recent studies on CUR) as a bioactive polyphenol with therapeutic usages demonstrated major challenges such as poor solubility, rapid metabolism, and limited bioavailability. Hence, many scholars have concerned these disadvantages and suggested promising carriers to enhance the pharmacokinetic properties of CUR. However, researches on understanding long-term safety, large-scale production, and clinical translation are limited. The present review paper explored recent advancements in copolymeric based CUR delivery systems with a special concentrate on its potentials and the further research possibilities. In vivo and in situ studies on CUR-leaded copolymer as well as the evaluation of full-scale applications are the most important issues that has been addressed less. [GRAPHICS]