Yazar "Gucin, Fahrettin" seçeneğine göre listele

Listeleniyor 1 - 5 / 5
  • [ X ]
    Öğe
    Antibacterial Activity of the Seeds of Hyoscyamus niger L. (Henbane)
    (Asian Journal Of Chemistry, 2010) Dulger, Basaran; Goncu, Beyza S.; Gucin, Fahrettin
    The methanolic extract obtained from the seeds of Hyoscyamus niger L. (Solanaceae) was investigated for its antibacterial activity against Bacillus subtilis ATCC 6633, Bacillus cereus ATCC 7064, Staphylococcus aureus ATCC 6538P, Escherichia coli ATCC 10538, Proteus vulgaris ATCC 6899, Salmonella typhimurium CCM 5445 and Pseudomonas aeruginosa ATCC 27853 by disc diffusion and microdilution method. The extracts showed strong antibacterial activity against Staphylococcus aureus, with inhibition zones of 25.0 mm and with minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of 16 (32) mu g/mL, respectively. Also, the extracts exhibited moderate activity the other test bacteria. The results demonstrate that the methanolic extract of the seeds of H. niger has significant activity and suggest that it may be useful in the treatment of infections.
  • [ X ]
    Öğe
    Antifungal Activity of Seeds of Hyoscyamus niger L. (Henbane) Against Some Clinically Relevant Fungal Pathogens
    (Asian Journal Of Chemistry, 2010) Dulger, Basaran; Hacioglu, Nurcihan; Goncu, Beyza S.; Gucin, Fahrettin
    The methanolic extracts obtained from the seeds of Hyoscyamus niger L. (Solanaceae) used as traditional medicine in Turkey were investigated for their ability to inhibit clinically relevant fungal pathogens as six Candida species (C. albicans ATCC 10231, C. tropicalis ATCC 13808, C. guilliermondii ATCC 6260, C. krusei ATCC 20298, C. glabrata ATCC 2001 neoformans ATCC 90112 and C. laurentii ATCC 34142) by microbroth dilution method. The plant displayed activity against all fungal cultures tested. The extracts possessed a strong antifungal potency Greater activity was observed against both Cryptococcus species, with MIC values of 15 mu g/mL.
  • [ X ]
    Öğe
    Antifungal activity of seeds of hyoseyamus niger L. (Henbane) against some clinically relevant fungal pathogens
    (Chemical Publishing Co., 2010) Dulger, Basaran; Hacioglu, Nurcihan; Goncu, Beyza S.; Gucin, Fahrettin
    The methanolic extracts obtained from the seeds of Hyoscyamus niger L. (Solanaceae) used as traditional medicine in Turkey were investigated for their ability to inhibit clinically relevant fungal pathogens as six Candida species (C. albicans ATCC 10231, C. tropicalis ATCC 13808, C. guilliermondii ATCC 6260, C. krusei ATCC 20298, C. glabrata ATCC 2001 and C. parapsilosis ATCC 22019) and two Cryptococcus species (C. neoformans ATCC 90112 and C. laurentii ATCC 34142) by microbroth dilution method. The plant displayed activity against all fungal cultures tested. The extracts possessed a strong antifungal potency. Greater activity was observed against both Cryptococcus species, with MIC values of 15 ?g/mL.
  • [ X ]
    Öğe
    Investigation of Raman, FT-IR, EPR spectra and antimicrobial activity of 2-(5-H/Me/Cl-1H-benzimidazol-2-yl)-phenol ligands and their Fe(NO3)3 complexes
    (Springer, 2007) Tavman, Aydin; Agh-Atabay, Naz M.; Guner, Sadik; Gucin, Fahrettin; Dulger, Basaran
    2-(5-H/Me/Cl-1H-benzimidazol-2-yl)-phenol ligands form 1:1 electrolytes, 5-coordinate monometallic complexes with iron(III) nitrate. The geometry of the [Fe(L)(OH)(H2O)(2)](NO3) complexes was derived from theoretical calculation in DGauss/DFT level (DZVP basis set) on CACHE. In all of the complexes the ligands are bidentate, via one imine nitrogen atom and phenolate oxygen atom. The coordination is completed with a hydroxide ion, and two water molecules, adopting a distorted square pyramidal geometry. The structures of the compounds were confirmed on the basis of elemental analysis, molar conductivity, magnetic moment, FT-Raman, FT-IR (mid-IR, far-IR), EPR and u.v.-vis. The antimicrobial activities of the free ligands, their hydrochloride salts, and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) dilution method, against nine bacteria and the results are compared with several known antibiotic agents. Antifungal activities were reported for Candida albicans, Kluyveromyces fragilis, Rhodotorula rubra, Debaryomyces hansenii, Hanseniaspora guilliermondii, and the results were referenced against nystatin, ketaconazole, and clotrimazole antifungal agents. In most cases, the compounds tested showed broad-spectrum (Gram(+) & Gram(-) bacteria) activities that were either more active or as potent as the references.
  • [ X ]
    Öğe
    Synthesis, FT-Raman, FT-IR, NMR spectroscopic characterization and antimicrobial activity of new mixed aza-oxo-thia macrocyclic compounds
    (Springer/Plenum Publishers, 2008) Aghatabay, Naz Mohammed; Mahmiani, Yaghub; Cevik, Hueseyin; Gucin, Fahrettin; Dulger, Basaran
    Series of new mixed aza-oxo-thia macrocyclic ligands {2,6,12,16-tetraaza-1,7,11,17-tetraoxo-9,19-dithia-[(4'-methyl-5',4,3')(14'-methyl-15',14,13')]ditriazine}cyclocosane (L-1 ); {2,6,13,17-teraaza-1,7,12,18-tetraoxo-9,10,20,21-tetrathia-[(4'-methyl-5',4,3')(15'-methyl-14',16',15)]di-triazine}cyclodocosane (L-2 ); {2,6,14,18-tetraaza-1,7,13,19-tetraoxo-10,22-dithia-[(4'-methyl-5',3',4)(16'-methyl-15',17',16)]ditriazine}cyclotetracosane (L-3 ) and {2,6,15,19-tetraaza-1,7,14,12-tetraoxo-10,11,23,24-tetrathia-[(4'-methyl-5',4,3')(17'-methyl-8',17,16')]ditriazine}cyclohexa-cosane (L-4 ) were synthesized. The structural features of the compounds have been studied by elemental analyses, Mass, FT-Raman, FT-IR, H-1 and C-13 NMR spectroscopy. The antimicrobial activities of the ligands were evaluated using disk diffusion method in dimethyl sulfoxide as well as the minimal inhibitory concentration (MIC) dilution method, against 9 bacteria. The obtained results from disk diffusion method were assessed in side-by-side comparison with those of Penicillin-g, Ampicillin, Cefotaxime, Vancomycin, Oflaxacin, and Tetracyclin, well-known antibacterial agents. The results from dilution procedure were compared with Gentamycin as antibacterial and Nystatin as antifungal. The antifungal activities are reported on five yeast cultures namely Candida albicans, Kluyveromyces fragilis, Rhodotorula rubra, Debaryomyces hansenii, and Hanseniaspora guilliermondii, and the results are referenced with Nystatin, Ketaconazole, and Clotrimazole, commercial antifungal agents. In most cases, the compounds show strong antifungal activity in the comparison tests.